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Biomedical subjects

F A Lee

Publications and source records attributed to F A Lee.

At least 37 records · Page 2Linked to original sources
PubMed1983

Brief clinical communication: neurogenic perineal prolapse in neonates.

Disturbed innervation of the pelvic muscular diaphragm from lumbosacral myelodysplasia and other osseous dysplasias results in flaccid paralysis of the perineum. This permits excessive downward herniation, most noticeable in neonates, of the lower abdominal and pelvic organs. The radiographic changes occurring with organ descensus may be transitory and diverse, and recognition of these various findings is important to avoid misdiagnosis and unnecessary further investigations. Several examples of the radiographic changes are presented.

Bone Diseases, Developmental↗
PubMed1980

Radiation therapy treatment of stage I and II extranodal non-Hodgkin's lymphoma of the head and neck.

We have reviewed the records of 76 patients with Stage I or II extranodal non-Hodgkin's lymphoma who were referred to the Division of Radiation Oncology, Mallinckrodt Institute of Radiology, during the years 1964 through 1974. The histologic slides were reviewed in the 67 cases in which they were available. Forty-three percent of Ann Arbor Stage I and II patients relapsed after primary radiation treatment.Seventy-three percent of these failed in sites distant from the irradiated volume. Failures in the treated volume were infrequent (7%) except in those patients presenting with primary lesions of the brain (4/5). Those patients presenting with lesions of Waldeyer's ring experienced a decrease in survival with increasing tumor size. Because of the high rate of failure in distant sites with tumors in the lingual and palatine tonsils, we are recommending the study of adjuvant chemotherapy in these cases, after primary radiation treatment.

Adolescent↗
PubMed1977

Combined treatment modalities of rhabdomyosarcoma in children.

Thirty-nine previously untreated children with rhabdomyosarcoma were managed by a coordinated program of surgery, radiation therapy, and chemotherapy during the years 1960 to 1973. The primary tumor was located in the head and neck (24), chest wall (1), abdomen (1), pelvis (10), and lower extremity (3). Radiation therapy consisted of tumor doses of 5000 to 6000 rads delivered in five to six weeks. Combination chemotherapy with actinomyctin-D, vincristine and cyclophosphamide was used after 1968. Seventeen of 25 cases (68%) treated after 1968 are alive two to five years following treatment. Only four of 14 cases (29%) who received less radical therapy before 1968 are alive. A relatively high incidence of local failure (23%) was noted in spite of adequate doses of radiotherapy. None of the four cases with metastatic disease at the time of diagnosis survived. Major complications were mainly noted in patients with orbital rhabdomyosarcoma. Correlation of absolute survival with dose of irradiation, primary site, extent of disease and histologic subtypes of the tumor are discussed.

Adolescent↗
PubMed1977

Radiographic features of fucosidosis.

Fucosidosis is an uncommonly recognized lysosomal storage disease which presents with psychomotor deterioration and progressing in some cases to death. The roentgenographic findings in five boys from three families are described. Skeletal abnormalities of a dysostosis multiplex nature are present and though not diagnostic should direct the clinician to perform appropriate biochemical and tissue assay studies to establish the diagnosis.

Adolescent↗