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Biomedical subjects

F A Klipstein

Publications and source records attributed to F A Klipstein.

At least 73 records · Page 4Linked to original sources
PubMed1975

Malabsorption of essential amino acids in tropical sprue.

The absorption of seven amino acids from an equimolar mixture containing each of the eight essential amino acids in a concentration of 20 mM was evaluated using a marker perfusion technique in 9 patients with untreated tropical sprue and in 6 healthy Puerto Rican control subjects. The rate of absorption of from two to six of the amino acids tested was lower in 7 of the patients than in the control subjects. The absorption of isoleucine, leucine, valine, and threonine was significantly lower in the group of sprue patients than in the control subjects. Treatment of 4 patients with oral tetracycline for 2 weeks was associated with return of amino acid absorption to normal in the 3 persons who had improved intestinal function, as tested by other parameters. More prolonged treatment was required for normalization of amino acid absorption in the 4th patient. These observations indicate that the absorption of certain essential amino acids is reduced in some patients with untreated tropical sprue.

Administration, Oral↗
PubMed1975

Pteroylglutamic acid malabsorption in tropical sprue.

Pteroylglutamic acid (PGA) absorption was assessed in ten untreated tropical sprue (TS) and eight control subjects utilizing a marker perfusion technique. Physiologic concentrations of the vitamin (25 ng/ml) dissolved in iso-osmotic solutions containing either mannitol of glucose at a concentration of 55.6 mM were perfused on each subject on two consecutive days. A statistically significant difference in PGA absorption between TS and control subjects was obtained only when glucose was present in the perfusate. Thus, unequivocal malabsorption of PGA is demonstrable in all subjects with TS when more refined techniques than the ones applied heretofore are utilized.

Adult↗
PubMed1974

Bile salt metabolism in tropical sprue.

Mean and peak jejunal bile salt concentrations during digestion of a standard fat meal were found to be significantly lower in six Puerto Rican patients with untreated tropical sprue, all of whom had steatorrhoea, than in six asymptomatic subjects who had normal fat absorption. Bile salt pool size and turnover time did not differ significantly in the two groups.It is suggested that bile salt concentrations may be reduced in the proximal small intestine of patients with tropical sprue as a result of excessive dilution by intestinal fluid. The finding of low bile salt concentrations in two asymptomatic subjects indicates that bile salt lack alone may not be sufficient to produce steatorrhoea.

Adult↗