Biomedical subjects

F A Kaszli

Publications and source records attributed to F A Kaszli.

8 recordsLinked to original sources

PubMed1997

[Comparison of subjective and objective parameters after oculomotor muscle surgery].

BACKGROUND: In regard to quality-control studies concerning strabismus surgery we were interested in a comparison of subjective and objective parameters after squint surgery. MATERIALS AND METHODS: In a questionnaire 175 patients were asked for their evaluation of the functional and cosmetic results 1 week and 6 weeks after squint surgery. Parallel, objective parameters like reduction of the squint angle and quality of stereopsis were documented. RESULTS: Overall 94.2% of patients with esotropia (n = 52) were satisfied cosmetically and 5.8% were not 1 week after squint surgery was performed. In the group of a patients with exotropia (n = 36), 91.7% of the patients were satisfied cosmetically and 8.3% were not. Even in cases of esotropia or exotropia no changes in the quality of stereopsis were noted by some patients or they could not be mentioned in the questionnaire. Some patients did not appreciate the improvement of binocular function found in our examination. CONCLUSIONS: Good congruence between objective and subjective results 1 week after squint surgery was found.

Adolescent↗

PubMed1997

[Quality of vision screening in childhood].

BACKGROUND: In Germany the paediatricians use three different visual acuity tests (Pictures, Rodenstock-Test, H-Test). We investigated the effectiveness of these procedures. SUBJECTS: In this study 303 children were referred by paediatricians to the study group in the Cologne Augenklinik. They were fully examined by an orthoptist and an ophthalmologist (gold standard). RESULTS: From these data the sensitivity and specificity of the tests used by the paediatricians were calculated. Only the H-Test proved to be satisfactory. CONCLUSION: The actual situation of screening for amblyopia by paediatricians in children aged 3 1/2 to 4 is unsatisfactory in Germany. Paediatricians and ophthalmologists should use a similar test for visual acuity. Continuing education of medical personnel is desirable to ensure an adequate quality of screening.

Amblyopia↗

PubMed1997

Do standard procedures in squint surgery influence the blood-aqueous barrier?

BACKGROUND AND OBJECTIVE: Surgery on the rectus muscles may interfere with anterior segment perfusion. This study investigates the influence of combined rectus muscle surgery on the blood-aqueous barrier in children. Namely, the influences of tucking and resection procedures were compared. PATIENTS AND METHODS: Laser flare measurements for tyndallometry were performed preoperatively and postoperatively in 25 children. Fifteen of the children had undergone a combination of a rectus recession and tucking; 10 had undergone a combined recession-resection procedure. RESULTS: The mean preoperative flare value was 4.1 photon counts/ms versus 3.7 photon counts/ms postoperatively in the eyes that had undergone surgery. Statistical evaluation showed that the postoperative changes were insignificant. No significant difference was found between the two surgical techniques (tucking vs resection) regarding the preoperative versus postoperative flare value change (level of statistical significance .05). CONCLUSION: Combined squint surgery, either recession-tucking or recession-resection, was not shown to influence the blood-aqueous barrier.

Anterior Eye Segment↗

PubMed1996

Tear film deficiencies pharmacology of eye drops and toxicity.

Our knowledge of the diagnosis and treatment of multifactorially induced dry eye has increased dramatically during the past few years. Major progress has taken place in the development of objective methods of evaluating and differentiating disturbances of the ocular lubrication. Various in vivo techniques for the diagnosis of tear film and corneal pathologies, including fluorophotometric tear flow, scanning confocal microscopy, infrared thermography, and fluorogenic substrate techniques, can be used quantitatively and qualitatively in clinical research. Eyedrop side effects such as epithelial cell toxicity and, especially, changes in epithelial membrane permeability after the administration of locally applied ophthalmic preparations are now detectable under in vivo conditions.

Animals↗

PubMed1996

[Disorder of the blood-aqueous barrier after eye muscle operation in children].

UNLABELLED: We wanted to study the effect of squint surgery on the blood-aqueous barrier in children. Our interest was to ascertain whether or not there is a breakdown of the blood-aqueous barrier after routine squint surgery, and whether this would need antiinflammatory treatment with steroids. PATIENTS AND METHODS: Forty-seven eyes of 18 girls and 7 boys (age range 4-14 years) were examined. The children were generally healthy and had not undergone any previous eye surgery. The mean age of patients (n = 25) was 7.8 +/- 3.1 years. Using the laser flare meter Kowa FM-500, the flare (photocounts/ms) in the anterior chamber was measured before and on the 2nd day after squint surgery (n = 32). Fifteen eyes served as controls and were not operated on. Following surgery, the operated eyes were treated with aminoglycoside eye drops (three times daily). No steroids or non-steroidal antiinflammatory drugs were applied before or after surgery. RESULTS: The flare values were 4.10 +/- 1.29 photocounts/ms before and 3.89 +/- 1.27 photocounts/ms after squint surgery. There was no significant increase (P = 0.58) of flare on the 2nd postoperative day. CONCLUSION: Our data confirm that there is no clinically significant disruption of the blood-aqueous barrier following squint surgery. We therefore conclude that there is no need for postoperative therapy with steroids.

Adolescent↗

PubMed1996

The influence of strabismus surgery on the blood-aqueous barrier: tyndallometry case studies in patients with risk factors.

We present tyndallometry as a method for investigation of subclinical changes in anterior-chamber flare in patients with risk factors regarding anterior-segment ischemia after squint surgery. The cases of six adult patients who underwent surgery on the vertical recti and who had additional risk either because of dysthyroid orbitopathy or because of transpositions carried out on the recti are presented. In one case a transient subclinical increase in the flare value was observed. This noninvasive method seems suitable for the provision of further information on the pathophysiology of anterior-segment ischemia and for monitoring of patients at special risk postoperatively such that early treatment can be started if necessary. Additionally, early detection of nonischemic intraocular inflammation in the postoperative course is rendered possible by this examination.

Adult↗

PubMed1995

[The dry eye].

Explore the source record for details and available documents.

Dry Eye Syndromes↗

PubMed1994

Changes in rabbit corneal epithelial membrane permeability caused by locally applied Pseudomonas aeruginosa cytotoxin: a microfluorometric examination in vivo.

The effects of a pore-forming protein from Pseudomonas aeruginosa on the rabbit cornea were tested in vivo by measuring intraepithelial carboxyfluorescein accumulation. Carboxyfluorescein diacetate and subsequently the P. aeruginosa cytotoxin were applied by means of contact lenses with a spherical cavity on the concave surface. This allowed the application of defined concentrations of carboxyfluorescein diacetate and cytotoxin on a defined area of the corneal epithelium. Starting at 0.5 microM, cytotoxin increased the epithelial cell membrane permeability for the intracellular carboxyfluorescein within 1 min. At higher concentrations cells were shed from the epithelium. Corresponding morphological changes of the cellular structure of the corneal epithelium were observed and documented by fluorescence photomicrography. The healing process of toxified corneal epithelium appeared to be complete within 3 days. The data presented here indicate the possible role of cytotoxin-induced changes in epithelial permeability in P. aeruginosa infections. In this context, the role of soft contact lenses as a possible cytotoxin reservoir is discussed.

ADP Ribose Transferases↗