Biomedical subjects
F A Jenner
Publications and source records attributed to F A Jenner.
Sweat electrolytes in manic-depressive illness.
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Some of the problems and difficulties associated with clinical studies of antidepressant agents.
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Studies of daily recordings from the Moos Menstrual Distress Questionnaire.
Nineteen volunteers completed a Moos Menstrual Distress Questionnaire daily for a period exceeding one menstrual cycle. The data were analysed, using a least mean square method of fitting sine waves. The fact that the results obtained on this group are essentially those found by other workers looking at the menstrual cycle suggests that this may be a useful method for assessing menstrual distress.
The effect of mild hyperventilation on red cell sodium.
Control subjects voluntarily overbreathed to produce end-tidal PCO2 levels similar to those found in patients suffering from neurotic or endogenous non-retarded depression. Red cell sodium content was found to decrease during overbreathing in all the subjects. The changes were similar to those usually reported for depressed patients. The results imply that red cell sodium levels are in part dependent on respiratory behaviour. They suggest a need for considerable caution in interpreting red cell sodium values from psychiatric patients.
Respiratory ventilation.
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Episodic secretion of growth hormone in a male trans-sexual during treatment with oestrogen both before and after orchidectomy.
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Alpha rhythm, laterality, lithium, and mood.
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Intracellular lithium and clinical response.
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Lithium and the antidiuretic hormone.
The effect of lithium on the urine concentrating response to antidiuretic hormone (ADH) and the excretion of ADH has been studied in rats and man. The maximum urine osmolarity following 18 h dehydration and Pitressin (5 u) was decreased in three out of four patients during lithium treatment compared to their response to the same test in the absence of lithium. In a fifth patient, tested only during lithium treatment, the urine remained hypotonic to plasma throughout this test. Lithium increased the excretion of ADH in non-polyuric patients from 9-22 mu/24 h in the absence of lithium to 36-202 mu/24 - during lithium treatment. In four patients with lithium-induced polyuria, a diuretic acting on the distal tubules, clorexolone, reduced the polyuria. Lithium increased urine volume and the excretion of ADH in four rats receiving lithium in their diet. The response to exogenous ADH was decreased during lithium administration.
Respiratory ventilation and carbon dioxide levels in syndromes of depression.
The breathing rate and PCO2 in end-tidal air have been studied in controls and in patients with endogenous depression (retarded and non-retarded), with neurotic depression, and with schizophrenia. It has been shown that breathing rate goes up and PCO2 down in non-retarded and neurotic depression. Schizophrenia gives more anomalous results. The fact is emphasized that such changes must lead to alterations in pH and other variables. Studies showing some small chemical differences between these clinical entities and control subjects might therefore be explained by these findings.
Proceedings: An effect of respiratory ventilation on erythrocyte sodium.
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Letter: Diuretics during lithium therapy.
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The role of noradrenaline, dopamine and 5-hydroxytryptamine in the hyperactivity response resulting from the administration of tranylcypramine to rats pretreated with lithium or rubidium.
1. The administration of 15 mg/kg tranylcypromine sulphate (Tc) to rats which have been given lithium chloride (LiCl) in the diet (30 mmol/kg dry food) for 14 days produces hyperactivity within 4 hrs, and this lasts for at least 4 further hours. 2. If LiCl is replaced by rubidium chloride (RbCl) at the same dose, the hyperactivity following Tc is increased and it appears within 2 hrs. 3. 5-Hydroxytryptamine (5HT) accumulation after a monoamine oxidase inhibitor (Tc) is increased 46% and 85% respectively above control values by LiCl and RbCl administration. 4. The hyperactivity produced by the above combinations is inhibited by alpha-methyl-p-tyrosine (alphampt). The inhibition is more effective following LiCl than RbCl treatment. 5. After sodium chloride (NaCl) and LiCl treatment, but not after RbCl treatment, the combination of alphampt and Tc produced rat brain concentrations of dopamine (DA) significantly below control values. 6. The smaller increase of brain noradrenaline (NA) after Tc and RbCl suggests that a lower percentage of NA is being metabolised by MAO. The greater decrease of NA after giving alphampt to RbCl and LiCl treated rats suggests an increased "turnover" rate of Na. 7. The hyperactivity syndrome seen in rats after the administration of LiCl or RbCl and Tc is dependent upon both 5HT and dopamine mechanisms.
The medicinal chemistry of lithium.
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Editorial: Circadian rhythms and mental illness.
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Urinary excretion of the sulphate and glucuronide of 3-methoxy-4-hydroxyphenylethyleneglycol in a manic-depressive patient.
The sulphate and glucuronide conjugates of 4-OH-3-methoxyphenylethyleneglycol (MOPEG) and 4-OH-3-methoxymandelic acid (VMA) have been serially studied in the urine of a manic-depressive patient before and after a therapeutic response to lithium carbonate. Excretion of both conjugates correlates with changes in mood. Some reasons to suggest that the sulphate might be a more useful measure of brain activity are stated.