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Biomedical subjects

F A Henn

Publications and source records attributed to F A Henn.

At least 73 records · Page 4Linked to original sources
PubMed1983

Uptake of adenosine into cultured cerebral endothelium.

Adenosine uptake by cultured cerebral endothelium is a carrier-mediated process. The Km value for adenosine uptake is 5.0 microM and the vmax is 1.15 nmol/min/mg cell protein. The uptake system is inhibited by the adenosine analog 2-chloroadenosine at low adenosine concentrations. The results prove the existence of a nucleoside transport system associated with cerebral capillary endothelium.

2-Chloroadenosine↗
PubMed1983

Tricyclics--the most common agent used in potentially lethal overdoses.

Fifty-three cases of drug overdose requiring admission to a medical intensive care unit were studied. Tricyclic antidepressants were used in nearly 50 per cent of these serious adult overdoses. Barbiturates were involved in only 20 per cent. This may reflect changing patterns of drug usage and emphasizes the potential danger of tricyclics, the use of which is widespread in the general medical community. Unintentional overdoses occurred most often in substance abusers, whereas intentional overdoses occurred in a wider range of psychiatric disorders. A quarter of drug overdoses were free of psychiatric disease. Patients found to have an obvious manipulative intent were as likely to have made medically serious attempts as those who did not.

Adult↗
PubMed1982

Modified leukotomy in the treatment of intractable obessional neurosis.

Modified leukotomies were performed on 5 patients with severe, incapacitating obsessional neurosis. Symptoms had been present for 6 or more years in all patients, and 3 had been ill for more than 20 years. All had received adequate trials of more conventional treatments before the leukotomy but had shown little response. At the time of follow-up, which range from as early as 1 year to as late as nearly 7 years after surgery, each patient's condition had improved. One was considered to be in "full remission," there were "much improved," and one was still symptomatic but "improved."

Adult↗
PubMed1980

Juvenile delinquents revisited. Adult criminal activity.

We examined the subsequent criminal activities of delinquent boys classified as having either socialized conduct disorder, undersocialized conduct disorder, aggressive type, or undersocialized conduct disorder, unaggressive type. A follow-up study of more than ten years revealed profound differences in the likelihood of criminal convictions or incarcerations between socialized and undersocialized delinquents. The socialized delinquents have less chance of being either convicted of a crime or being imprisoned. This difference supports the previous studies that demonstrated that these classifications could be distinguished on the basis of differences in behavior, personality, psychological test results, and characteristic family backgrounds, and reinforces this method of classifying conduct disorders. Differences between the undersocialized aggressive and unaggressive groups appear qualitative and indicate that subjects in the former group are involved in more crimes of violence subjects in the latter.

Adolescent↗
PubMed1978

Dopamine and schizophrenia. A therapy revisited and revised.

Evidence is presented for a modulatory role for dopamine in the C.N.S. and for an indirect rather than a direct involvement of dopaminergic systems in the production of schizophrenic symptoms. The fine structure of dopaminergic fibres indicates that a majority of presynaptic boutons are not in close juxtaposition with postsynaptic neuronal membranes. This points to a wider distribution of receptors than localisation to dense postsynaptic membrane. Preliminary studies of receptor localisation support this conclusion, providing indirect evidence for autoreceptors and evidence for localisation, in the glia, of a substantial number of receptors.

Adenylyl Cyclase Inhibitors↗
PubMed1977

Forensic psychiatry: female offenders.

The authors examined the records of 127 female and 1,068 male offenders referred by the courts to a forensic service over a 22-year-period. Female offenders were less likely than male offenders to be referred for psychiatric evaluations when they were charged with criminal behavior. They were more likely to be charged with homicide, arson, forgery, or fraud and more frequently received diagnoses of affective disorder and neurosis.

Affective Symptoms↗