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Biomedical subjects

F A Fuhrman

Publications and source records attributed to F A Fuhrman.

36 records · Page 2Linked to original sources
PubMed1966

Blockage of sodium conductance increase in lobster giant axon by tarichatoxin (tetrodotoxin).

Tarichatoxin, isolated from California newt eggs, has been found to selectively block the increase of sodium conductance associated with excitation in lobster giant axons at nanomolar concentrations. This resulted from a reduction in the amplitude of the conductance increase rather than a change in its temporal characteristics. The normal potassium conductance increase with depolarization is not altered. A high concentration of calcium applied concomitantly with the toxin significantly improves the reversibility of the sodium blocking. This toxin has recently been identified as chemically identical with tetrodotoxin from the puffer fish. Toxins from the two sources are equally effective and are shown to have an action which is distinctly different from that of procaine.

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PubMedDate not supplied

Doridosine, 1-methylisoguanosine, from Anisodoris nobilis; structure, pharmacological properties and synthesis.

The new N-methylnucleoside named doridosine, isolated from the shell-less marine dorid nudibranch Anisodoris nobilis, has been identified as 1-methylisoguanosine (1) by its spectral properties and by synthesis via methylation of isoguanosine. Doridosine has been shown to be identical to the nucleoside isolated from the Australian sponge Tedania digitata by Quinn, Gregson, Cook and Bartlett. They have also proved their product to be 1-methylisoguanosine. Doridosine was shown to cause prolonged reduced arterial pressure and reduced heart rate in the rat. The action is qualitatively similar to that of adenosine but of much greater duration, possibly because doridosine is resistant to attack by adenosine deaminase.

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