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Biomedical subjects

F A Fried

Publications and source records attributed to F A Fried.

At least 55 records · Page 3Linked to original sources
PubMed1978

Microradiographic demonstration of pyelolymphatic backflow in the porcine kidney.

Pyelolymphatic backflow occurs when intrapelvic pressure rises acutely. Although peripelvic and hilar lymphatics have occasionally been demonstrated during intravenous urography and retrograde pyelography, the patterns of intrarenal microlymphatic filling have not previously been studied radiographically in multipapillary kidneys. Microradiography was performed after retrograde ureteral injections of barium sulfate suspension in recently excised pig kidneys. Contrast filled the ducts of Bellini and extended in a retrograde fashion as far as the distal convoluted tubules. Intrarenal cortical and corticomedullary microlymphatics, as well as veins, filled following forniceal rupture and interstitial extravasation. These anatomic studies suggest that the renal lymphatics may function as an alternate pathway of drainage of an acutely obstructed kidney.

Animals↗
PubMed1977

Pheochromocytoma: recent experience with detection and management.

Our experiences spanning a ten-year period have been reviewed with regard to pheochromocytoma. During this period 1,890 metanephrine excretion levels were performed; 91 of these were elevated. An over-all incidence of 1.9 per cent false positive studies was found. Factors contributing to the false positive studies are discussed. Fourteen patients had 15 pheochromocytomas resected. The presenting features, diagnosis, localization, preoperative and operative management, as well as the results are presented.

Adolescent↗
PubMed1977

Childhood gonadoblastoma and seminoma in a dysgenetic cryptorchid gonad.

A case of gonadoblastoma and seminoma occurring in a genotypic male child with ambiguous genitalia is presented. A review of the literature establishes that children with intersex disorders who possess a Y chromosome and undescended gonads stand a particularly high risk of having this type of gonadal neoplasm and should be explored.

Child, Preschool↗
PubMed1977

Renal toxicity. Tobramycin and gentamicin.

The new aminoglycoside, tobramycin sulfate, has been shown to be effective against the same microorganisms for which gentamicin is currently employed. This study compares the effects of these two antibiotics on renal function and ultrastructure in guinea pigs. Significant differences in the blood urea nitrogen of treated and nontreated groups, as well as between the gentamicin- and tobramycin-treated groups were observed. Gentamicin produced greater, more rapid elevations of the blood urea nitrogen, although all elevations were reversible. The ultrastructural pathology produced by tobramycin was similar to that previously described for gentamicin.

Animals↗
PubMed1976

Cell-mediated immunity in renal cell carcinoma-preliminary report.

The microcytotoxicity test was used in 8 cases post-nephrectomy for renal cell carcinoma to stage the disease clinically and to evaluate immunologically. Half of the patients had stage IV disease and half were believed to be cured clinically. Cell-mediated immunity and serum blocking factors were found in all patients with known metastases. However, cellular immunity was not found in 3 of the 4 remaining patients and serum blocking factors were also not noted in the 2 clinically cured patients who were tested. These findings are compatible with the facts that cell-mediated immunity and serum blocking factors are found when there is a grossly discernible antigenic source, that serum blocking factors are lost in patients who are clinically free of tumor and that in some patients who are clinically cured with a possible total loss of antigenic presence there is a disappearance of significant cell-mediated immunity.

Adenocarcinoma↗
PubMed1976

The role of ultrasonics in the evaluation of renal masses.

Analysis of our experience with echography in the evaluation of renal masses reveals an error rate of 31 per cent. Presently, this technique may be useful in directing the evaluation of a renal mass to either arteriography, if a tumor is suspected, or needle aspiration and renal cystogram, if a cyst is suspected. However, echography should not replace more definitive studies.

Diagnostic Errors↗
PubMed1975

The place of bone scan in the diagnosis of renal cell carcinoma.

We herein review 12 cases of renal cell carcinoma evaluated by bone scan and skeletal survey. Comparison of these techniques revealed a high incidence of falsely negative results (42 per cent) when using skeletal survey alone. It is now our policy to include the bone scan in our initial evaluation of patients with renal cell carcinoma.

Adenocarcinoma↗
PubMed1975

Aggressive surgery for renal cell carcinoma with ena cava tumor thrombus.

Herein is presented what we believe to be the eighth case reported of renal cell carcinoma with caval tumor thrombus treated by radical excision with vena caval resection. A review of the literature reveals that although postoperative morbidity is minimal, only 1 patient survived more than two years. All patients with metastases at time of operation died within one year. It is our conclusion that the length and quality of survival anticipated must be carefully weighed before performing this major surgical procedure.

Adenocarcinoma↗
PubMed1975

Pathogenesis of pyelonephritis. Escherichia coli-induced renal ultrastructural changes.

Escherichia coli-induced renal ultrastructural changes were observed 4 hr after the intravenous injection of 2 times 10-minus 6 bacteria. The initial changes consisted of mitochondrial swelling followed by intracellular vacuolation, nuclear membrane dilation, and increased lysosomal phagocytic activity. Alterations in the appearance of proximal tubular lysosomes included a loss of osmiophilic staining properties. Many of the involved cells showed necrosis and can presumably act as a nidus for bacterial proliferation.

Animals↗