Mesenteric venous thrombosis mimicking rectal carcinoma and presenting as a distal large bowel obstruction.
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Aged↗
Biomedical subjects
F A Farraye
Publications and source records attributed to F A Farraye.
The association between the myelodysplastic syndromes and Crohn disease.
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Aged↗
Hepatic schistosomiasis: report of two cases and literature review.
Two Filipino patients were referred for evaluation of abnormal liver enzymes. Both patients were known to come from regions endemic for Schistosoma japonicum. The clinical laboratory and radiological features of these patients are presented. We highlight the findings of radiologic evaluation, including magnetic resonance imaging (MRI). The epidemiology, clinical manifestations, diagnostic strategies including a comparison of the utility of ultrasound, computed tomography, and MRI are reviewed. The pathophysiology responsible for hepatic manifestations of schistosomiasis is reviewed. An increased influx to the United States of persons from regions endemic for schistosomiasis, such as South America, Southeast Asia, and the Philippines, will result in an increase in the prevalence of the disease in this country. The diagnosis of hepatic schistosomiasis will need to be considered in populations at risk for contracting this common worldwide problem.
Adult↗
Fulminant hepatic failure following bone marrow transplantation for hepatitis-associated aplastic anemia.
A case of aplastic anemia associated with non-A, non-B hepatitis was initially successfully treated by bone marrow transplantation. The patient subsequently developed fulminant hepatic failure. Fulminant hepatic failure is rare in bone marrow transplantation and only occurs in association with aplastic anemia associated with viral hepatitis. This case helps to highlight the relationships between the immune system, hepatitis, and bone marrow failure.
Adolescent↗
Preliminary evidence that azidothymidine does not affect hepatitis B virus replication in acquired immunodeficiency syndrome (AIDS) patients.
The effect of azidothymidine (AZT) on hepatitis B virus (HBV) replication was determined in three patients with the acquired immunodeficiency syndrome (AIDS). Serum viral DNA was present, and its concentration either remained the same or increased in two patients. Since AIDS patients may be infected with a variety of viral agents in addition to the human immunodeficiency virus (HIV), the effects of the antiviral agents and biological modifiers on other common viral infections should also be determined in developing new approaches to HIV infection. Our results give preliminary evidence that AZT does not affect HBV viral replication in vivo.
Acquired Immunodeficiency Syndrome↗
Segmental colitis associated with Aeromonas hydrophila.
We describe a 40-yr-old woman who presented with abdominal pain and diarrhea, and who was found to have segmental colitis involving the cecum and ascending colon. Aeromonas hydrophila was isolated from the stool, and her symptoms responded to appropriate antibiotic therapy. Follow-up colonoscopy confirmed complete endoscopic and histologic resolution of her colitis. This report further supports the belief that Aeromonas species are pathogens in healthy humans. This organism needs to be considered in the differential diagnosis of diffuse and segmental colitis.
Adult↗
Acute small-bowel mucosal edema following enalapril use.
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Adult↗
Primary hepatocellular carcinoma in idiopathic hemochromatosis after reversal of cirrhosis.
Previous reports have emphasized the association of primary hepatocellular carcinoma in patients with idiopathic hemochromatosis with cirrhosis. In contrast, patients with idiopathic hemochromatosis without cirrhosis have no increased risk of hepatocellular carcinoma. Phlebotomy therapy, by preventing the accumulation of parenchymal iron and subsequent cirrhosis, is believed to prevent hepatocellular carcinoma in the precirrhotic stage of the disease. We report the case of a 67-yr-old man with a 32-yr history of idiopathic hemochromatosis complicated by cirrhosis, who had reversal of cirrhosis with phlebotomy therapy, yet developed hepatocellular carcinoma. There was no serologic or tissue evidence of hepatitis B infection.
Aged↗
In vitro hepatitis B virus suppression of erythropoiesis is dependent on the multiplicity of infection and is reversible with anti-HBs antibodies.
Exposure of human bone marrow mononuclear cells to hepatitis B virus results in the suppression of the in vitro growth of several hematopoietic progenitor cells. We studied the degree of inhibition of erythroid progenitor cells that results as a function of the time of exposure of mononuclear cells to hepatitis B virus and the ratio of virus to mononuclear cells, the multiplicity of infection. With an overnight incubation of mononuclear cells with hepatitis B virus-containing sera, a multiplicity of infection of greater than one virus per mononuclear cell is required to observe significant inhibition of erythroid colony formation. This multiplicity of infection effect is also observed with purified Dane particles. Exposure of mononuclear cells to an increasing number of Dane particles results in a dose-dependent suppression of erythroid colony formation with significant inhibition observed with a multiplicity of infection of virus to mononuclear cells as low as 5:1. Murine monoclonal antibodies to HBsAg completely neutralize the hepatitis B virus-mediated inhibition of CFU-E while control antibodies do not. Purified HBsAg has no effect on colony formation. In conclusion, the hepatitis B virus-mediated inhibition of erythrogenesis in vitro provides a basis for understanding the bone marrow depression observed during hepatitis B virus infections and may provide an in vitro model for examining hepatitis B virus infection.
Bone Marrow↗