Interrelations between biological rhythms and clocks.
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Biomedical subjects
Publications and source records attributed to F A Brown.
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Organismic sensitivity to atmospheric electromagnetic forces, together with usually asymmetrical phase-response systems, have enabled a simple unified explanation of the biological clocks and their timed rhythms. The clocks, endogenous cycles synchronized by subtle geophysical Zeitgeber, are always accurate. The rhythms, freely phase labile, autophase in "constant conditions" to generate a host of overt frequencies.
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A technique for assay of lecithinase antibodies in serum was developed in this laboratory by using a lecithin-agar plate diffusion procedure based on a combination of described plate assays. Egg yolk lipoprotein composed primarily of lecithin was used as a substrate for reaction with free or non-neutralized lecithinase C after incubation of known amounts of lecithinase C with various dilutions of control and test sera. It was found that the size of the reaction zone was a function of enzyme concentration and inversely proportional to the antibody concentration. Accuracy and precision of the assay were determined. In addition, lecithinase antibody levels in sera from experimentally inoculated rats and rabbits and sera from randomly selected human patients were studied.
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