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Eva Negri

Publications and source records attributed to Eva Negri.

At least 37 records · Page 2Linked to original sources
PubMed2006

Genital and urinary tract diseases and prostate cancer risk.

The objectives of this study were to investigate whether venereal diseases, prostatic and urinary infections, and other selected conditions of the genital and urinary tracts may have a role in the development of prostate cancer. We analysed data from a hospital-based case-control study conducted between 1985 and 1992 in Italy, including 280 cases of prostatic cancer and 689 controls, hospitalized for acute, non-neoplastic, non-genital or urinary tract conditions. We calculated odds ratios and 95% confidence intervals using unconditional multiple logistic regression. The odds ratios of prostate cancer were 0.64 for history of selected venereal diseases, 0.53 for prostatitis, 0.67 for benign prostatic hyperplasia, 1.53 for urinary tract stones and 1.76 for cystitis. No relationship, however, was observed for cystitis>or=5 years before prostate cancer. The present study, based on satisfactorily reproducible information on medical history, did not found any association between genital and urinary tract diseases and prostate cancer risk.

Adult↗
PubMed2006

Family history of hemolymphopoietic and other cancers and risk of non-Hodgkin's lymphoma.

We investigated the risk of lymphomas, hemolymphopoietic (HLP) cancers (including lymphomas), and non-HLP cancers in first-degree relatives of non-Hodgkin's lymphoma (NHL) cases in an Italian case-control study on 225 patients (median age, 59 years) with a new diagnosis of NHL and 504 hospital controls (median age, 63 years), admitted for a wide spectrum of acute, nonneoplastic, nonimmune conditions. We estimated odds ratios (OR) adjusted for sex, age, family size, and other potential confounders. We also built the cohort of all first-degree relatives and computed age and sex adjusted hazard ratios (HR) using proportional hazard models. A history of lymphoma in first-degree relatives was reported by 5 NHL cases and 3 controls [OR, 3.2; 95% confidence interval (95% CI), 0.7-14.4] whereas 14 cases and 11 controls reported a family history of HLP cancers (OR, 3.0; 95% CI, 1.2-7.0). The HR of relatives of NHL cases, compared with relatives of controls, was 4.5 (95% CI, 1.1-18.8) for lymphomas, 3.5 (95% CI, 1.5-7.4) for HLP cancers, 1.6 (95% CI, 1.3-2.0) for all cancers, and 1.0 (95% CI, 0.9-1.1) for all causes of deaths. The HRs were higher for relatives of NHL cases diagnosed before the age of 50 years: 7.1 for HLP cancers, 2.0 for all cancers, and 1.6 for all deaths. A family history of cancer of the liver (OR, 2.1; 95% CI, 1.0-4.2), breast (OR, 2.0; 95% CI, 1.0-3.6), and kidney (OR, 4.6; 95% CI, 1.0-20.9) increased NHL risk. The OR was also elevated for all cancer sites (OR, 1.7 95% CI, 1.2-2.4) and the risk increased with the number of affected relatives also when HLP cancers were excluded.

Adult↗
PubMed2006

Flavonoids and colorectal cancer in Italy.

Because of their several biological activities, flavonoids may have an important role in explaining the protective effects of vegetables, fruit, and, possibly, tea against cancer. The potential relation between flavonoids and colorectal cancer risk was investigated using data from a multicentric Italian case-control study, including 1,953 cases of colorectal cancers (1,225 colon cancers and 728 rectal cancers) and 4,154 hospital controls admitted for acute nonneoplastic diseases. We have applied recently published data on the composition of foods and beverages, in terms of six principal classes of flavonoids, on dietary information collected through a validated food-frequency questionnaire. Odds ratios (OR) were estimated by multiple logistic regression models, including terms for sex, age, study center, family history of colorectal cancer, education, alcohol consumption, body mass index, physical activity, and energy intake. A reduced risk of colorectal cancer was found for increasing intake of isoflavones (OR, 0.76, for the highest versus the lowest quintile, P(trend) = 0.001), anthocyanidins (OR, 0.67, P(trend) < 0.001), flavones (OR, 0.78, P(trend) = 0.004), and flavonols (OR, 0.64, P(trend) < 0.001). No significant association was found for flavan-3-ols (OR, 0.98), flavanones (OR, 0.96), and total flavonoids (OR, 0.97). The estimates did not substantially differ for colon and rectal cancers, as well as in strata of sex, age, and body mass index. The findings of this large study provide support for an inverse association of selected classes of flavonoids with colorectal cancer risk.

Adult↗
PubMed2005

Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy.

OBJECTIVE: To analyze the relationship between surgically treated benign prostatic hyperplasia (BPH) and intake of selected micronutrients. METHODS: A multicentric case-control study was conducted in Italy between 1991 and 2002. Cases were 1369 men with histologically confirmed, surgically treated BPH and controls were 1451 men younger than 75 yr, frequency matched by quinquennium of age and study center, admitted to the hospital for acute nonneoplastic diseases. Information was collected by trained interviewers using a structured validated food-frequency questionnaire. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multiple logistic regression models. RESULTS: The risk of BPH significantly decreased with increasing intake of carotene (OR=0.80 for an increment equal to the difference between the 80th and 20th percentile of intake), alpha-carotene (OR=0.83), beta-carotene (OR=0.82), and cis beta-carotene (OR=0.82) and tended to decrease with the intake of vitamin C (OR=0.89) and iron (OR=0.79). The OR tended to increase with the intake of sodium (OR=1.30) and zinc (OR=1.10). No systematic heterogeneity was observed across strata of age, education, and body mass index. No meaningful associations emerged for other antioxidants, such as folic acid, lycopene, lutein/zeaxanthin, vitamin E, vitamin D, nor for retinol. CONCLUSIONS: Our results suggest a protective effect of carotene on the risk of BPH. The risk tended to decrease also with the intake of vitamin C and iron and tended to increase with the intake of sodium and zinc. Results also indicate that other antioxidants, including folic acid, lycopene, lutein/zeaxanthin, and vitamins D and E, and retinol were not related to the risk for this disease.

Adult↗
PubMed2005

Influenza vaccine in healthy children: a meta-analysis.

We conducted a meta-analysis of 13 randomised clinical trials evaluating the efficacy of influenza vaccine in healthy children. Against culture-confirmed influenza the overall efficacy was 74% (95% confidence interval, CI, 57%-84%), 65% for inactivated and 80% for live-attenuated vaccine. Corresponding figures were 59% (95% CI 43%-71%), 63% and 54% for serologically-confirmed influenza, and 33% (95% CI 29%-36%), 33% and 34% for clinical illness. Influenza vaccine is effective in preventing laboratory-confirmed and clinical influenza in healthy children, with no clear difference between inactivated and live-attenuated vaccine. Data on infants and younger children were too scanty to allow separate assessment.

Adolescent↗
PubMed2005

Family history of cancer and the risk of prostate cancer and benign prostatic hyperplasia.

We analysed the relation between family history of cancer in first-degree relatives and risk of prostate cancer (PC) and benign prostatic hyperplasia (BPH) using data from a multicentric case-control study conducted in Italy from 1991 to 2002 on 1,294 cases of incident, histologically confirmed PC, 1,369 cases of BPH and 1,451 men admitted to the same network of hospitals for acute, nonneoplastic conditions. Unconditional logistic regression was used to estimate odds ratios (OR) of PC and BPH, adjusted for age and other confounders. Men with a family history of PC had an OR of PC of 4.0 (95% confidence interval [CI] 2.5-6.5), and the risk was higher when the proband was younger, when 2 or more relatives were affected or when the affected relative was a brother. The risk of PC was also increased in men with a family history of cancer of the ovary (OR = 6.2, 95% CI 1.2-32), bladder (OR = 3.5, 95% CI 1.6-7.4) and kidney (OR = 3.1, 95% CI 1.1-8.5). An involvement of breast/ovarian cancer predisposition genes in a small proportion of PCs was suggested by the cluster of these cancers in female relatives of a few PC cases. The risk of BPH was increased in men with a family history of bladder cancer (OR = 2.2, 95% CI 1.0-5.0) but not PC (OR = 1.2, 95% CI 0.7-2.2). Our study adds further information on the association of family history of cancer and risk of PC and is, to our knowledge, the first comprehensive epidemiologic information on family history of cancer and risk of BPH.

Aged↗
PubMed2005

Lifetime physical activity and prostate cancer risk.

The purpose of our study was to investigate the relation in between physical activity in different periods of life at work and in leisure-time and prostate cancer risk. We conducted a case-control study on prostate cancer in Italy between 1991 and 2002, which included 1,294 incident cases of histologically confirmed prostate cancer below 75 years of age and 1,451 controls, who were admitted to hospital for acute nonneoplastic conditions. Odds ratios (OR) of prostate cancer according to physical activity in different periods of life were obtained by unconditional multiple logistic regression models, including terms for age, study centre, education, social class, body mass index, energy intake, family history and other selected covariates. Compared to the lowest level of occupational physical activity, the multivariate ORs for prostate cancer for the highest level were 0.94 (95% confidence interval, CI, 0.75-1.17) at age 15-19, 0.78 (95% CI, 0.63-0.97) at age 30-39 and 0.75 (95% CI, 0.61-0.93) at age 50-59. A significant inverse trend in risk was found for activity at work at ages 30-39 and 50-59. The inverse associations were consistent in strata of age at diagnosis, body mass index, education and social class. No significant association was found for leisure-time physical activity. The inverse association between occupational physical activity and prostate cancer risk may reflect favorable hormonal correlates of physical activity, but residual confounding by socioeconomic covariates cannot be excluded.

Age Factors↗
PubMed2005

Hormone replacement therapy and risk of nonfatal acute myocardial infarction in Italy.

BACKGROUND: Observational studies, but not clinical trials, found lower risk of coronary heart disease (CHD) in hormone replacement therapy (HRT) users. We analyzed the relation between HRT use and the risk of nonfatal acute myocardial infarction (AMI) in Italy. METHODS: We used a combined dataset from three hospital-based case-control studies including a total of 479 women aged > or =45 years with a first episode of nonfatal AMI and 822 hospital controls. RESULTS: Compared to never-HRT users, the multivariate odds ratio in ever users was 1.4 (95% confidence interval, 0.9-2.2); no consistent pattern of risk was observed according to duration or time since last use. CONCLUSIONS: HRT use was not associated with nonfatal AMI in Italian women according to the findings of clinical trials.

Age Distribution↗
PubMed2005

Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer.

OBJECTIVES: A relation of prostate cancer risk with calcium, vitamin D and phosphorus has been suggested, but remains controversial. METHODS: A case-control study was conducted in Italy in 1991-2002. Cases were 1294 men with incident prostate cancer, and controls were 1451 men admitted to hospital for acute non-neoplastic diseases. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression. RESULTS: Compared to the lowest one quintile of dietary calcium intake the OR was 1.18 for the highest, 1.01 for an increment of 622 mg/day of calcium, and 1.29 (95% CI 0.78-2.13) for 2000 mg/day or more of calcium. The OR of prostate cancer for the highest quintile of dietary intake of vitamin D and phosphorus were 1.33 and 1.20 respectively. CONCLUSIONS: This study shows no material association of dietary intake of calcium, vitamin D and phosphorus with prostate cancer risk.

Aged↗
PubMed2005

Hair dye use and risk of lymphoid neoplasms and soft tissue sarcomas.

We analyzed the relation between hair dye use and the risk of Hodgkin's disease (HD), non-Hodgkin's lymphoma (NHL), multiple myeloma (MM) and soft tissue sarcomas (STS) in a hospital-based case-control study conducted between 1985 and 1997 in northern Italy. Cases included 158 patients with histologically confirmed incident HD, 446 with NHL, 141 with MM, 221 with STS and controls included 1,295 patients with acute nonneoplastic conditions. Compared to never use of any type of hair dyes, the odds ratio (OR) for ever use was 0.68 (95% confidence interval, CI, 0.40-1.18) for HD, 1.03 (95% CI 0.73-1.44) for NHL, 1.17 (95% CI 0.70-1.97) for MM and 0.73 (95% CI 0.45-1.17) for STS. The OR were close to unity for permanent and semipermanent dyes analyzed separately or when the analysis was restricted to women. Our study indicates that there is no appreciable association between ever use of any type of hair dyes and the risk of HD, NHL, MM or STS.

Adolescent↗
PubMed2005

Converging patterns of colorectal cancer mortality in Europe.

Trends in mortality rates from colorectal cancer during the second half of the 20th century were analysed for 21 European countries and grouped in three broad European regions. For each gender, age-standardised (world standard population) mortality rates were computed by the direct method, and joinpoint analysis was used to identify significant changes in rates. A favourable pattern in colorectal cancer mortality for both genders was observed in most European countries from the 1990s onwards. Colorectal cancer mortality rates were still in the upward direction in some Eastern European countries, as well as in some Mediterranean countries. Mortality rates tended to converge at around 20/100000 in men and around 11/100000 in women. This converging pattern is even clearer when colorectal mortality rates are examined in three broad European regions. Similar mortality rates over recent calendar years have been reached by countries where mortality has been decreasing in recent decades and in those countries (mainly Eastern European and Mediterranean countries) which have experienced a recent levelling-off and decrease. If recent trends are maintained, colorectal cancer mortality is likely to decline further in Europe in the current decade.

Adult↗
PubMed2005

Breastfeeding and the risk of epithelial ovarian cancer in an Italian population.

OBJECTIVES: Breastfeeding has been inversely related to the risk of ovarian cancer, but results from published studies are inconsistent. In order to provide further information, we analyzed data from a large case-control study conducted in four Italian areas. METHODS: Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. RESULTS: There were inverse trends in risk with increasing duration of breastfeeding and number of children breastfed, but when parity and several other potential confounding factors were taken into account, no residual association was evident (odds ratio = 1.21 for 17 or more months of breastfeeding and 0.90 for those who had breastfed 4 or more children, as compared to women who had never breastfed). CONCLUSIONS: This study showed an inverse relation between breastfeeding and ovarian cancer risk, which however was accounted for by parity. The analyses by histologic subtypes suggested that a role of breastfeeding would be larger for serous neoplasms in the absence, however, of significant heterogeneity.

Adult↗
PubMed2005

The risk of acute myocardial infarction after stopping drinking.

BACKGROUND: Subjects at high risk of alcohol-related diseases may benefit from alcohol cessation. However, drinkers have a lower risk of acute myocardial infarction (AMI) than abstainers, and there is very scanty information on how the risk changes after stopping drinking. METHODS: Between 1995 and 1999, we administered a structured questionnaire to 507 cases (378 men, 129 women) with a first episode of nonfatal AMI and 478 control patients (297 men, 181 women) admitted to the same network of hospitals in the greater Milan area for acute conditions. RESULTS: Compared to lifelong abstainers, the odds ratio (OR) adjusted for age, sex, and several AMI risk factors was 0.56 (95% confidence interval [CI] 0.41-0.84) for current and 0.65 (95% CI 0.37-1.15) for former drinkers (48 cases and 44 controls). The OR was 2.10 (0.40-11.1) for having stopped since 1 year, 0.64 (95% CI 0.19-2.16) for 2-4 years, 0.46 (95% CI 0.18-1.20) for 5-14 years, and 0.78 (95% CI 0.27-2.27) for > or = 15 years. CONCLUSIONS: Although our data are too limited to draw any definite conclusion, they suggest that the protection of alcohol drinking against AMI may persist, at least in part, for several years after stopping.

Age Distribution↗
PubMed2005

Monitoring the decrease in breast cancer mortality in Europe.

Trends in mortality from breast cancer over the period 1970-2000 were analysed for 38 European countries and the European Union (EU). Age-standardized mortality rates were computed by the direct method, and joinpoint analysis was used to identify significant changes in rates. A favourable pattern in breast cancer mortality in the 25 countries of the EU (as defined in May 2004) was observed after 1989, leading to a fall in overall rates from 21.3/100,000 in 1990 to 18.9 in 2000. The annual percentage change in the EU was -2.1% between 1995 and 2000. Most northern European countries, including several Scandinavian countries and the UK, but also some central and southern European countries like Germany, Poland, the Czech Republic, Austria, Switzerland, Italy and Spain showed appreciable falls in rates (i.e. between 8 and 19% in the last 5 calendar years). The declines were larger below age 50, approaching 20% in several countries. The falls were smaller in France, Greece, Portugal and most eastern European countries. In the Russian Federation, all-age breast cancer mortality increased from 16.1 to 17.3/100,000 (+7.5% over the last 5 calendar years). These patterns reflect converging trends in breast cancer rates across Europe, which can be related to the more uniform reproductive and lifestyle habits. The fall in breast cancer mortality observed in most European countries over the last decade has to be attributed to earlier detection and improved treatment, although the definite reasons for the different trends in various countries remain at least in part unclear.

Adult↗