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Biomedical subjects

Eng Hin Lee

Publications and source records attributed to Eng Hin Lee.

25 records · Page 2Linked to original sources
PubMed2002

The treatment outcome of trigger thumb in children.

Our objectives were to determine the treatment outcome of trigger thumb and to identify its possible cause. One hundred and thirty-eight thumbs from 115 children were reviewed. There was an overall success rate of 66% following conservative treatment and the success rate appears to be higher in the younger age group and in those treated with splint therapy, which includes wearing a splint and regular therapy exercises. The outcome of the children who underwent surgery was good with a recurrence rate of 1.4% and a wound infection rate of 2.8%. Our results suggest that a more conservative approach to this problem should be adopted. Our data also suggest that this condition may be acquired rather than congenital.

Child, Preschool↗
PubMed2002

Academic medicine.

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Academic Medical Centers↗
PubMedDate not supplied

Chitin as a scaffold for mesenchymal stem cells transfers in the treatment of partial growth arrest.

To investigate the feasibility of using chitin, a natural polymer, as a scaffold to repair large growth plate defects (50% of physis) in immature rabbits, mesenchymal stem cells (MSCs) were harvested from periosteum. The compatibilities of chitin with the MSCs were investigated in vitro using immunohistochemistry and fluorescence confocal microscopy. The results showed high compatibilities of chitin. An experimental model of growth arrest was created by excising the medial half of the proximal growth plate of the tibia in 6-week-old New Zealand White rabbits. The physeal defect after excision of the bony bridge was transplanted either with no interposition (group 1), chitin alone (group 2), or chitin with MSCs (group 3). In groups 2 and 3, both angulatory deformities and length discrepancies of the tibia were corrected. The differences between group 3 and group 1 were greater than those between group 2 and group 1.

Animals↗
PubMedDate not supplied

Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models.

Management of chondral lesions in osteochondritis dissecans remains a challenge. This study investigated the efficacy of periosteal graft, osteochondroidal autograft, autologous chondrocyte and mesenchymal stem cell transplants in the treatment of chondral lesions in animal models. Full-thickness articular cartilage defects were created in the weight-bearing surface of the medial femoral condyle in 20-week-old NZW rabbits. A total of 56 knees were randomly divided into four groups as follows: group 1, transfer of cultured chondrocytes; group 2, transfer of cultured mesenchymal stem cells; group 3, repair by periosteal graft; and group 4, mosaicplasty. All of the contralateral knees served as control. Gross, histologic, and biomechanical examinations at 36 weeks after the operation showed that the cultured chondrocytes and mesenchymal stem cells had comparable enhancing effects on the repair of chondral defects in advanced osteochondritis dissecans, whereas mosaicplasty did well initially and periosteal graft did less favorably.

Animals↗