Biomedical subjects

Emmanuel Dupoux

Publications and source records attributed to Emmanuel Dupoux.

7 recordsLinked to original sources

PubMed2006

The role of the striatum in processing language rules: evidence from word perception in Huntington's disease.

On the assumption that linguistic faculties reflect both lexical storage in the temporal cortex and combinatorial rules in the striatal circuits, several authors have shown that striatal-damaged patients are impaired with conjugation rules while retaining lexical knowledge of irregular verbs [Teichmann, M., Dupoux, E., Kouider, S., Brugières, P., Boissé, M. F., Baudic, S., Cesaro, P., Peschanski, M., & Bachoud-Lévi, A. C. (2005). The role of the striatum in rule application. The model of Huntington's disease at early stage. Brain, 128, 1155-1167; Ullman, M. T., Corkin, S., Coppola, M., Hickok, G., Growdon, J. H., Koroshetz, W. J., & Pinker, S. (1997). A neural dissociation within language: Evidence that the mental dictionary is part of declarative memory, and that grammatical rules are processed by the procedural system. Journal of Cognitive Neuroscience, 9, 266-276]. Yet, such impairment was documented only with explicit conjugation tasks in the production domain. Little is known about whether it generalizes to other language modalities such as perception and whether it refers to implicit language processing or rather to intentional rule operations through executive functions. We investigated these issues by assessing perceptive processing of conjugated verb forms in a model of striatal dysfunction, namely, in Huntington's Disease (HD) at early stages. Rule application and lexical processes were evaluated in an explicit task (acceptability judgments on verb and nonword forms) and in an implicit task (lexical decision on frequency-manipulated verb forms). HD patients were also assessed in executive functions, and striatal atrophy was evaluated with magnetic resonance imaging (bicaudate ratio). Results from both tasks showed that HD patients were selectively impaired for rule application but lexical abilities were spared. Bicaudate ratios correlated with rule scores on both tasks, whereas executive parameters only correlated with scores on the explicit task. We argue that the striatum has a core function in linguistic rule application generalizing to perceptive aspects of morphological operations and pertaining to implicit language processes. In addition, we suggest that the striatum may enclose computational circuits that underpin explicit manipulation of regularities.

Adult↗

PubMed2005

The acquisition of allophonic rules: statistical learning with linguistic constraints.

Phonological rules relate surface phonetic word forms to abstract underlying forms that are stored in the lexicon. Infants must thus acquire these rules in order to infer the abstract representation of words. We implement a statistical learning algorithm for the acquisition of one type of rule, namely allophony, which introduces context-sensitive phonetic variants of phonemes. This algorithm is based on the observation that different realizations of a single phoneme typically do not appear in the same contexts (ideally, they have complementary distributions). In particular, it measures the discrepancies in context probabilities for each pair of phonetic segments. In Experiment 1, we test the algorithm's performances on a pseudo-language and show that it is robust to statistical noise due to sampling and coding errors, and to non-systematic rule application. In Experiment 2, we show that a natural corpus of semiphonetically transcribed child-directed speech in French presents a very large number of near-complementary distributions that do not correspond to existing allophonic rules. These spurious allophonic rules can be eliminated by a linguistically motivated filtering mechanism based on a phonetic representation of segments. We discuss the role of a priori linguistic knowledge in the statistical learning of phonology.

Humans↗

PubMed2005

The role of the striatum in rule application: the model of Huntington's disease at early stage.

The role of the basal ganglia, and more specifically of the striatum, in language is still debated. Recent studies have proposed that linguistic abilities involve two distinct types of processes: the retrieving of stored information, implicating temporal lobe areas, and the application of combinatorial rules, implicating fronto-striatal circuits. Studies of patients with focal lesions and neurodegenerative diseases have suggested a role for the striatum in morphological rule application, but functional imaging studies found that the left caudate was involved in syntactic processing and not morphological processing. In the present study, we tested the view that the basal ganglia are involved in rule application and not in lexical retrieving in a model of striatal dysfunction, namely Huntington's disease at early stages. We assessed the rule-lexicon dichotomy in the linguistic domain with morphology (conjugation of non-verbs and verbs) and syntax (sentence comprehension) and in a non-linguistic domain with arithmetic operations (subtraction and multiplication). Thirty Huntington's disease patients (15 at stage I and 15 at stage II) and 20 controls matched for their age and cultural level were included in this study. Huntington's disease patients were also assessed using the Unified Huntington's Disease Rating Scale (UHDRS) and MRI. We found that early Huntington's disease patients were impaired in rule application in the linguistic and non-linguistic domains (morphology, syntax and subtraction), whereas they were broadly spared with lexical processing. The pattern of performance was similar in patients at stage I and stage II, except that stage II patients were more impaired in all tasks assessing rules and had in addition a very slight impairment in the lexical condition of conjugation. Finally, syntactic rule abilities correlated with all markers of the disease evolution including bicaudate ratio and performance in executive function, whereas there was no correlation with arithmetic and morphological abilities. Together, this suggests that the striatum is involved in rule processing more than in lexical processing and that it extends to linguistic and non-linguistic domains. These results are discussed in terms of domain-specific versus domain-general processes of rule application.

Adult↗

PubMed2005

Subliminal speech priming.

We present a novel subliminal priming technique that operates in the auditory modality. Masking is achieved by hiding a spoken word within a stream of time-compressed speechlike sounds with similar spectral characteristics. Participants were unable to consciously identify the hidden words, yet reliable repetition priming was found. This effect was unaffected by a change in the speaker's voice and remained restricted to lexical processing. The results show that the speech modality, like the written modality, involves the automatic extraction of abstract word-form representations that do not include nonlinguistic details. In both cases, priming operates at the level of discrete and abstract lexical entries and is little influenced by overlap in form or semantics.

Acoustic Stimulation↗

PubMed2004

Partial awareness creates the "illusion" of subliminal semantic priming.

We argue that the lack of consensus regarding the existence of subliminal semantic processing arises from not taking into account the fact that linguistic stimuli are represented across several processing levels (features, letters, word form) that can independently reach or not reach awareness. Using masked words, we constructed conditions in which participants were aware of some letters or fragments of a word, while remaining unaware of the whole word. Three experiments using the Stroop priming paradigm show that when the stimulus set is reduced and participants are encouraged to guess the identity of the prime, such partially perceived stimuli can nonetheless give rise to "semantic" processing. We provide evidence that this effect is due to illusory reconstruction of the incompletely perceived stimulus, followed by usual semantic processing of the result. We conclude that previously reported unconscious Stroop priming is in fact a conscious effect, but applied to a perceptual illusion.

Attention↗

PubMed2003

Phonological grammar shapes the auditory cortex: a functional magnetic resonance imaging study.

Languages differ depending on the set of basic sounds they use (the inventory of consonants and vowels) and on the way in which these sounds can be combined to make up words and phrases (phonological grammar). Previous research has shown that our inventory of consonants and vowels affects the way in which our brains decode foreign sounds (Goto, 1971; Näätänen et al., 1997; Kuhl, 2000). Here, we show that phonological grammar has an equally potent effect. We build on previous research, which shows that stimuli that are phonologically ungrammatical are assimilated to the closest grammatical form in the language (Dupoux et al., 1999). In a cross-linguistic design using French and Japanese participants and a fast event-related functional magnetic resonance imaging (fMRI) paradigm, we show that phonological grammar involves the left superior temporal and the left anterior supramarginal gyri, two regions previously associated with the processing of human vocal sounds.

Acoustic Stimulation↗

PubMed2003

Lexical access without attention? Explorations using dichotic priming.

The authors used lexical decision in a dichotic listening situation and measured identity priming across channels to explore whether unattended stimuli can be processed lexically. In 6 experiments, temporal synchronization of prime and target words was manipulated, and acoustic saliency of the unattended prime was varied by embedding it in a carrier sentence or in babble speech. When the prime was acoustically salient, a cross-channel priming effect emerged, and participants were aware of the prime. When the prime was less salient, no identity priming was found, and participants failed to notice the prime. Saliency was manipulated in ways that did not degrade the prime. Results are inconsistent with models of late filtering, which predict equal priming irrespective of prime saliency.

Analysis of Variance↗