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Elizabeth M Adler

Publications and source records attributed to Elizabeth M Adler.

16 recordsLinked to original sources
PubMed2007

2006: signaling breakthroughs of the year.

With nominations from leading scientists studying cell signaling, the STKE editors compile a list of the year's most important advances. Signaling breakthroughs included molecules and processes both outside cells and inside cells, from channels in the membrane to chromatin in the nucleus. The nominated research ranged from structural and functional revelations to approaches for the global analysis of signaling pathways. Receptors were highlighted with unexpected proteins functioning as receptors, as well as surprising functions for known receptors. This year also brought new insights into the impact of cell signaling on human physiology and disease.

Animals↗
PubMed2006

Assessing undergraduate laboratory performance.

The lab notebook is one element for assessing student laboratory performance. However, it is also important to be able to communicate research results in a journal article format and a visual poster format. Another key aspect to scientific research is the ability to present a research plan. This article describes four assessment tools that can be used in conjunction with undergraduate lab courses that provide the opportunity for the students to practice each of these essential communication skills.

Audiovisual Aids↗
PubMed2006

Differentiation of PC12 cells.

This 3-week-long series of collaborative laboratory exercises explores how to use a cultured cell system (PC12 cells) to study signaling pathways involved in cellular differentiation. The laboratory would be useful in a neurobiology or cell biology course for advanced undergraduate students. The background and details for performing the lab are provided along with suggestions for assessing student performance and understanding.

Animals↗
PubMed2006

Teaching resources. Cell culture as a model system for teaching: using PC12 cells.

This Teaching Resource provides an introduction to the use of cultured cells as an experimental approach in undergraduate laboratory research and the study of neuronal differentiation in PC12 cells. In addition, a thought experiment with answers is provided that can be used to assess student understanding of (i) the scientific method, (ii) signaling processes involved in cellular differentiation, and (iii) the use of pharmacological agents to manipulate a cell culture system.

Animals↗
PubMed2006

Teaching resources. The Sherlock Holmes lab: investigations in neurophysiology.

This Teaching Resource describes a research project that can be used in an advanced undergraduate course in neurobiology that covers basic electrophysiology and synaptic transmission. A thought experiment is provided that can be used to assess student understanding of (i) the scientific method, (ii) the process whereby nerve stimulation leads to muscle contraction, and (iii) the use of pharmacological agents to analyze a physiological system.

Animals↗
PubMed2006

2005: signaling breakthroughs of the year.

2005 was particularly notable for the range and scope of exciting advances in cell signaling research. Nominations from leading scientists ranged from plant signaling, neurobiology, and immunology to systems biology and structural biology. In plant biology, a new piece added to a long-standing puzzle in auxin signaling was discovered. The exploitation and regulation of RNA in cell signaling was also in the limelight. Intriguing new twists were highlighted in relation to functional and dysfunctional signaling in the brain, calcium-mediated signals, and the innate immune response. Finally, mathematical and statistical analysis of biochemical networks provided new insights into the circuitry of cell signaling pathways.

Biology↗
PubMed2005

Focus issue: memories of signals past--plastic changes in nervous system function.

Plasticity encompasses the ability of the nervous system to adapt to injury and the ability of the developing and mature brain to change in response to experience. This week's Special Issue of Science focuses on systems-level approaches to understanding cortical plasticity, especially during development. The accompanying Focus Issue of Science's STKE features articles and resources that address issues related to the molecular changes that underlie synaptic plasticity in response to physiological or pathological stimuli.

Animals↗
PubMed2005

Cell signaling: from beginning to end.

The Connections Maps database and the graphical Web interface at Science's STKE for accessing the data represent an emerging Web-based tool through which researchers in cell signaling can share their knowledge with the scientific community. This tool provides a mechanism by which researchers, students, and clinicians can transform information about interactions between biomolecules into knowledge about a cellular process. In 2005, new Pathways were added to the Connections Maps database and several of the existing Pathways were updated.

Cooperative Behavior↗
PubMed2005

Focus issue: RNA, a multifunctional molecule.

This week's issues of Science, Science's STKE, and SAGE KE (www.sciencemag.org/sciext/rna/) focus on the increasing complexity that RNA brings to cellular biology. STKE resources include Reviews, Perspectives, and Teaching Resources. STKE specifically looks at the roles for small RNAs in regulation of gene expression and how mRNAs can be selectively activated from cytoplasmic macromolecular structures, RNA granules, to contribute to such processes as synaptic plasticity.

Animals↗
PubMed2005

Signals from the past.

Science's STKE celebrates Science's 125th anniversary issue by presenting 12 notable articles from Science that highlight different aspects of cell signaling research.

Animals↗
PubMed2005

Focus issue: going for the gut.

This week's issues of Science and Science's STKE cover various aspects of gastrointestinal function and malfunction. Topics include the regulation of feeding behavior, host interactions with the organisms that colonize the gut, signaling pathways involved in gut barrier function and self-renewal, and factors associated with gastrointestinal inflammatory disorders and the pathogenesis of gastrointestinal cancers.

Aggression↗
PubMed2005

Focus issue: diabetes--fighting fat on multiple fronts.

Diabetes, an increasing problem worldwide, involves both insulin resistance and deficiencies in insulin secretion. This week's issues of Science and Science's STKE explore genetic factors that predispose to the development of diabetes as well as the links between diabetes and obesity.

Adipose Tissue↗
PubMed2004

Teaching resources. Chloride concentration and pH along the endosomal pathway.

This animation depicts three membrane trafficking routes in a mammalian neurosecretory cell, highlighting the changing Cl- concentrations and pH values of the various endosomal subcompartments. The focus is on the endocytotic pathway and the different paths taken by clathrin-coated vesicles: the pathway for receptor recycling to the plasma membrane, the lysosomal pathway, or the pathway for synaptic vesicle recycling (in neurons). Each compartment shown has a distinctive pH and [Cl-], with values for pH indicated in blue and values for Cl- indicated in orange. This animation will be useful for teaching cell biology and highlighting both the dynamic nature of vesicular traffic and the changes in ionic balance associated with different cellular compartments.

Chlorides↗