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Biomedical subjects

Elias Homsioglou

Publications and source records attributed to Elias Homsioglou.

5 recordsLinked to original sources
PubMed2007

Pneumatized superior turbinate as a cause of headache.

BACKGROUND: A pneumatized superior turbinate is a rare cause of headache. Nasal endoscopy alone, does not provide us with adequate information for this inaccessible area of the superior nasal cavity. A coronal computed tomography (CT) must be obtained to confirm the diagnosis. CASE PRESENTATION: We present a 40-year-old female with migraine-type headache and nasal obstruction. Nasal endoscopy revealed a mild septal deviation, a right middle concha bullosa and a paradoxically curved middle turbinate on the left side. Coronal CT-scan showed also the presence of a superior concha bullosa on the left, which was in close contact with the nasal septum. The patient underwent septoplasty and bilateral endoscopic sinus surgery, including partial removal of both the pneumatized middle turbinates in conjunction with gentle lateralization and resection of the lower half of the left superior turbinate. Prompt relief from headache and nasal symptoms was obtained. CONCLUSION: Pneumatized superior concha causing migrainous headache is a rare finding. Endoscopic surgery may provide permanent relief of symptoms.

Adult↗
PubMed2007

Normative values of olfactory function testing using the 'sniffin' sticks'.

OBJECTIVES: Quantitative olfactory assessment is often neglected in clinical practice, although olfactory loss can assist to diagnosis and may lead to significant morbidity. "Sniffin' Sticks" is a modern test of nasal chemosensory performance that is based on penlike odor-dispensing devices. It consists of three tests of olfactory function: odor threshold, odor discrimination, and odor identification. The results of this test may be presented as a composite threshold-discrimination-identification (TDI) score. The aim of this study was first to develop normative data of olfactory function for the Greek population using this test and second to relate olfactory performance to age, sex, and side examined. STUDY DESIGN: The authors conducted a prospective clinical trial. METHODS: A total of 93 healthy subjects were included in the study, 48 males and 45 females, mean age of 44.5 years (range, 6-84 years). RESULTS: A database of normal values for olfactory testing was established for the Greek population. Females performed better than males and older subjects performed less efficiently in all tests. We also found a right nostril advantage compared with the left. Additionally, scores obtained from bilateral presentation were similar with scores obtained from the nostril with the better performance. CONCLUSIONS: The "Sniffin' Sticks" can be used effectively in the Greek population to evaluate olfactory performance. Mean values of olfactory tests obtained were better in comparison with data from settings located in central and northern Europe.

Adolescent↗
PubMed2005

Drug eruptions in children with ENT infections.

OBJECTIVE: A common problem for the clinician in an outpatient clinic is to distinguish a drug eruption from a viral exanthem in a child. The aim of this study was to describe the common drug eruptions seen in children with ENT infections, suggesting an approach to this problem. METHODS: We studied the cases of ENT patients aged 15-years-old and below, with the clinical diagnosis of cutaneous adverse reactions. Main variables in the assessment of drug etiology in skin eruptions were previous experience with the drug in the general population, alternative explanation for the eruption, timing between the ingestion of the drug and the appearance of the lesions, drug levels or evidence of overdose or long-acting drug, subsequent progression of the eruption and reactions to dechallenge and rechallenge. RESULTS: A total of 47 children were examined during a period of 11 months. The indications for drug prescribed were tonsillitis, pharyngitis, rhinitis, otitis and sinusitis. The most usually implicated drugs were amoxycillin-clavulanic acid, cephalosporin, clindamycin, erythromycin, clarithromycin and paracetamol. The main clinical patterns of the eruptions seen were urticaria, maculopapular rash, fixed drug eruption and erythema multiforme. CONCLUSIONS: Careful clinical examination, detailed history, knowledge of the numerous clinical patterns of the eruptions and the drugs specific reaction rates, as well as oral drug rechallenge, RAST and patch tests if indicated, are essential factors in the management of patients with drug eruptions.

Acetaminophen↗
PubMed2004

Correlation of transiently evoked otoacoustic emission measures to auditory thresholds.

BACKGROUND: The presence of otoacoustic emissions is objective evidence of normal cochlear status. However, this test cannot be used to predict absolute auditory thresholds with accuracy. The criteria of normal otoacoustic emissions are not yet standardized and different measures of otoacoustic emissions have been used in various settings. In this study, the measures of reproducibility and otoacoustic emission amplitude are compared with regard to their correlation to pure-tone auditory (PTA) thresholds. MATERIAL/METHODS: One hundred and seventeen subjects with normal hearing were included in the study. Subjects with previous audiological, otolaryngologic, or vestibular disease were excluded. A complete ENT and audiological work-up was performed, including transiently evoked otoacoustic emissions (TEOAEs). The equipment used for TEOAE testing was a DP Echoport ILO 292 Otodynamics analyzer connected to a portable personal computer. A full 260 low-noise samples were averaged. Correlation between PTA thresholds and either overall TEOAE amplitude or whole reproducibility was estimated using multiple regression analysis. RESULTS: Correlation between acoustic thresholds at 250, 500, 1000, 2000, 4000 and 8000 Hz and either whole reproducibility or emission amplitude was highly significant for both measures. However, whole reproducibility was better correlated to acoustic thresholds at 250, 500, 1000, 2000, 4000 and 8000 Hz than was emission amplitude, and was more accurately predicted from multiple regression equations. CONCLUSIONS: Reproducibility measures performed better than TEOAE amplitude levels in the prediction of auditory thresholds.

Acoustic Stimulation↗