Biomedical subjects

E van Pinxteren-Nagler

Publications and source records attributed to E van Pinxteren-Nagler.

3 recordsLinked to original sources

PubMed2000

[Routine laboratory tests unnecessary for children referred for recurrent wheezing and/or asthma].

OBJECTIVE: To investigate the usefulness of laboratory testing and thorax radiography in children, referred to the paediatrician for evaluation of recurrent wheezing. DESIGN: Retrospective. METHODS: In this study, 158 children referred for recurrent wheezing to a specialized child outpatient clinic of the Medisch Centrum Leeuwarden, the Netherlands, in the period 1 January 1994-31 December 1996, were evaluated according to a routine protocol including haemoglobin, ESR, leucocytes, immunoglobulins, sweat chloride levels and allergy testing and chest roentgenograms. It was determined whether these investigations had yielded abnormal results and whether these test results aided in confirming/rejecting the diagnosis of asthma or were helpful in clinical management. RESULTS: In 144 of the 158 (91%) children the diagnosis 'asthma' or 'recurrent wheezing' was made. Although numerous test results were abnormal they were not helpful in establishing the diagnosis. In only one child an abnormal chest radiograph was helpful (the radiograph showed infiltrative abnormalities). Tests for aero-allergy were rarely positive in children younger than 2 years; in children older than 6 years aero-allergy was found frequently, notably to dust mite (41/144). CONCLUSION: The results of this study suggest that--except for allergy testing--routine laboratory testing and chest roentgenograms are not indicated in children referred for evaluation of wheezing disorders. Aero-allergy testing may help to decide on preventive measures.

Asthma↗

PubMed2000

[Acute renal insufficiency caused by bilateral ureteral obstruction after appendectomy in a 6-year old boy].

A 6-year-old boy developed macroscopic haematuria on the 4th day after appendectomy for acute appendicitis, at which the appendix was found to be perforated. During the next few days the urine secretion decreased and malaise, pain in the lower abdomen, nausea and vomiting occurred. On a management of ample fluid administration, the urine secretion recovered and the symptoms subsided in a few days. In the early postoperative stage after appendectomy in children the possibility should be kept in mind of the development of acute renal insufficiency due to bilateral ureteral obstruction as a result of oedema of the posterior bladder wall, even if by means of ultrasonography only mild to moderate abnormalities are noted. Awaiting decompression by means of the introduction of bilateral ureteric stents, in order to prevent irreversible renal damage, supportive therapy with fluid administration depending on the diuresis seems indicated.

Acute Kidney Injury↗

PubMed1996

[Progressive partial lipodystrophy; an external problem with internal anomalies].

Progressive partial lipodystrophy (PPL) was diagnosed in two girls aged 6 and 8 years. PPL is characterized by loss of subcutaneous fat, starting in the face and progressing to trunk and arms. Diagnosis is based upon the cachectic appearance and the normal growth parameters. It is a rare disease of unknown aetiology, usually beginning in childhood and more frequent in females. An association with diabetes mellitus, hypertriglyceridaemia and glomerulonephritis has been described. Follow-up should be focused on these and on psychological effects. No causal therapy is available. The facial appearance can be restored by injection of liquid silicones. Life expectancy does not appear to be affected.

Child↗