Biomedical subjects
E de Maeyer
Publications and source records attributed to E de Maeyer.
Production by mixed lymphocyte cultures of a type II interferon able to protect macrophages against virus infection.
In supernatants of mixed mouse spleen cell cultures established for 4 days, a species-specific inhibitor of virus replication with a broad antiviral spectrum was found. The inhibitor was destroyed by trypsin, was nondialyzable and acid labile, and was not neutralized by antibody to mouse L cell interferon. This indicates that in mixed lymphocyte cultures a type II interferon is made that has no immunological relationship with "fibroblast" interferon. This leukocyte product was shown to protect mouse hepatitis viruses. It is suggested that lymphocyte interferon may collaborate with macrophages in host defense against viruses, as a mediator of cellular immunity.
[The chromophore of blue dextran: a powerful ligand for the purification of interferon by affinity chromatography].
The chromophore of blue dextran can be used as ligand for affinity chromatography of interferon. One passage of a crude interferon preparation on a blue-dextran-sepharose column eliminates over 90% of the contaminating proteins. Desorption with an aqueous buffer of high molarity yields interferon preparations with specific activities of up to 4.5 X 10(6) units per milligram of protein and the recovery is 100%.
[Prolongation, by interferon, of the survival of skin grafts in the mouse].
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Effect of antilymphocytic serum on circulating interferon in mice as a function of the inducer.
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Interferon synthesis in x-irradiated animals. I. Depression of circulating interferon in C3H mice after whole-body irradiation.
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