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Biomedical subjects

E Zanette

Publications and source records attributed to E Zanette.

24 records · Page 2Linked to original sources
PubMedDate not supplied

Animal model of TIA: an experimental study with intracarotid ADP infusion in rabbits.

Adenosine diphosphate (8 mg per minute for five minutes) was infused into the carotid artery of 63 rabbits. The effects were twofold: systemic hypotension and platelet aggregation in the cerebral circulation. As a consequence of the last effect, platelet emboli were produced which occluded cerebral arteries in a number and size sufficient to cause cerebral ischemia. Areas of focal ischemia were observed through a cranial window, and documented with antipyrine autoradiography. Platelet thrombi were almost entirely transient, being fragmented and removed within a very short time of cessation of ADP infusion. Consequently, no permanent tissue damage ensued. This experimental model approaches the spontaneous transient ischemia attacks (TIAs) in man, demonstrating that these can be caused by pure platelet emboli. A high cholesterol diet administered for two months prior to ADP infusion did not enhance the effect of the procedure or make the platelet aggregation and the following ischemia longer in duration or more severe.

Adenosine Diphosphate↗
PubMedDate not supplied

Echodensitometry: a methodologic approach to the non-invasive diagnosis of carotid atherosclerotic plaques.

The ultrasound image of the fibroatheromatous plaque has to date been unable to reveal the presence or absence of complications as shown by histology, such as thrombosis and intraplaque hemorrhage. We propose a novel densitometric method for determining the composition of the plaque at the echotomography, along with a new classification based on mathematical models drawn from the optical density distribution curve. This approach avails of an extremely high sensitivity. Percent areas occupied by thrombosis, intraplaque hemorrhage and atheroma in histologic sections have been shown to correspond to hyporeflecting areas in echotomographic images, whereas those occupied by calcium and fibrous tissue correspond to reflecting areas with or without acoustic shadow, respectively. This method may prove to have an important role in the non-invasive monitoring of even slight changes during progression or regression of the fibroatheromatous plaque.

Arteriosclerosis↗
PubMedDate not supplied

Histopathological characterization of carotid plaques echotomography.

The positive correlation between cerebral ischemia and carotid atherosclerosis of extracranial tract has been well established. The reliability of echotomography as diagnostic and prognostic tool in the evaluation of the carotid atherosclerotic lesions is now intensively investigated. Most of the attention has been payed to the accuracy in the determination of the carotid stenosis. A percentage of cerebrovascular accidents do not correlate to the vascular stenosis but to the other modifications induced by the atherosclerotic plaque, such as the release of emboli, acute stenosis for intraplaque haemorrhage or thrombosis. Thus the evaluation of the composition of the plaque may represent a good prognostic tool. In the present study, fifty-two carotid obtained at surgery from patients, who preoperatively underwent ultrasonographic scanning of both carotid arteries, were examined by histological methods. In calcified tissues a significant correlation between findings obtained with both techniques was observed. In the complicated plaques atheromasic gruel, intraplaque haemorrhages and thrombosis could not be discriminated by echotomography.

Carotid Arteries↗
PubMedDate not supplied

The combined use of radionuclide angiography and Doppler-sonography in the screening of carotid lesions.

The aim of our research is to check if the combined use of radionuclide angiography and Doppler-sonography leads to correct screening of carotid lesions in the neck, independently from the indexes of reliability of the individual examinations. 125 cerebrovascular patients (for a total of 250 carotid studies) were investigated with radionuclide angiography and Doppler-sonography. 100 of these carotids were also angiographically investigated. On the basis combined angioscintigraphic and Doppler results, these patients have been classified in four groups. When both non-invasive examinations result negative, the angiography shows pathological arteries only in 22% of cases. When only radionuclide angiography is positive, the angiography shows pathological findings in 63% of cases: when only Doppler is positive, the angiography confirmation occurs in 72% of cases. Finally, when both non-invasive tests results positive, there is always arterial pathology in the angiography.

Adult↗