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Biomedical subjects

E Yuval

Publications and source records attributed to E Yuval.

7 recordsLinked to original sources

Treatment of superficial bladder tumors in a controlled trial with thio-TEPA versus adriamycin.

Forty-six patients with superficial transitional cell carcinoma of the bladder were randomized into two groups. Thio-TEPA or adriamycin were instilled periodically into the bladder and cystoscopic follow up was carried out. Both thio-TEPA and adriamycin proved to have similar efficacy in delaying tumor recurrence. Further investigations to establish better dose and interval schedules are indicated.

Administration, Topical↗

Sacrococcygeal dysgenesis.

Congenital sacrococcygeal dysplasia is an uncommon though important cause of neuropathic bladder disease leading to progressive renal damage. In 2 cases described herein and featuring long-standing incontinence and recurrent infections, the concomittant musculoskeletal abnormalities had been treated for years, while the urinary tract condition had been largely neglected until urinary diversion or unilateral nephrectomy were required.

Adolescent↗

Retrocaval ureter.

3 cases of retrocaval ureter (one of them presenting multiple urological anomalies) are discussed. In the presence of hydronephrosis, early operative reposition of the ureter is essential. Provided that the condition is diagnosed before extreme renal deterioration, the surgical repair can salvage remaining renal function.

Adult↗

Familial primary vesicoureteral reflux.

Two families with all children affected by primary vesicoureteral reflux are reported. Both sets of parents were examined and only in one family the mother was also affected by unilateral reflux. This congenital lesion has only recently been recognized as a common disease, but because diagnosis depends on voiding cystography, it is not made until the child or adult becomes symptomatic or presents with end-stage renal disease. As most cases are sporadic, a multiple factorial mode of inheritance is most probable, but an autosomal dominant or recessive gene cannot be excluded as the cause of the disease in some families. It is recommended that all first degree relatives of the patients should be investigated, in order to detect asymptomatic cases of this condition, which is likely to cause progressive renal damage and may have fatal termination due to renal failure.

Child↗