False diagnosis of legionellosis.
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Biomedical subjects
Publications and source records attributed to E Yourassowsky.
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Urinary tract infection caused by beta-lactamase-producing bacteria were treated with 500 mg of amoxicillin three times daily plus either 250 or 125 mg of clavulanic acid three times daily. The overall cure rate was 63.6%, 77.7% with the high dose of clavulanic acid and 53.8% with the low dose. Gastrointestinal intolerance was common in the high-dose clavulanic acid regimen.
Growth curve studies (MS-2 Abbott) of Escherichia coli and Pseudomonas aeruginosa cultures submitted to different beta-lactams concentrations showed that a) the maximal values of residual growth (MVRG) observed in the first hours of contact between antibiotic and bacteria was either concentration dependent (carbenicillin, ticarcillin, moxalactam, ceftazidime, cefsulodin against Escherichia coli) or concentration independent (azlocillin, mezlocillin, piperacillin against E. coli and all beta-lactams against P. aeruginosa) ; b) a relationship was found between MVRG and lag of regrowth in the postantibiotic period ; c) the MVRG independent of antibiotic concentration was associated with filament formation. This observation may contribute to athe best choice of the mode of administration of an antibiotic in therapeutic field (peak level or plateau).
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During an 8-year period (1970-1977), 24 strains of Salmonella spp. were isolated in 24 renal transplant recipients. In 19 cases (79%) the infection had an unusual presentation (extradigestive focus or bacteraemia), and 15 of the offending strains belonged to the serotype typhimurium. During the same period 161 strains of Salmonella spp. were isolated in 159 adult patients admitted to units other than the renal transplantation unit; 52% of the infections presented as gastroenteritis, and S. typhimurium accounted for only 25% of unusual presentations. However, the lysotypes and biotypes of S. typhimurium were as diverse in the renal transplantation unit as in other hospital units. The study failed to demonstrate interhuman transmission of Salmonella spp. within the renal transplantation unit.
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Methicillin- and gentamicin-resistant Staphylococcus aureus may remain sensitive to minocycline and to rifampicin. A study of growth curves has shown that at inhibitory concentrations (0.4 mug/ml), minocycline prevents the development of mutants resistant to rifampicin.
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Ninety-one strains of coagulase-negative Staphylococci isolated from urine specimens of patients with urinary tract infection were classified by the kloos and Schleifer method. The study confirmed the pathogenic role played by S. saprophyticus--an organism characterized by its biological properties and its resistance to novobiocin--in UTI of young female out-patients. On the other hand, coagulase-negative Staphylococci sensitive to novobiocin were mostly found in the urine of elderly in-patients who had undergone instrumental procedures or who presented with urinary tract abnormalities. Precise identification of coagulase-negative Staphylococci urinary isolates is needed, since it has epidemiological, clinical and therapeutic applications.
A 71-year-old patient living in a street where major road works were taking place developed diffuse bronchopneumonia with changes in hepatic and renal biochemical tests. Since neutrophilia was moderate and all bacteriological investigations were negative, the patient was given erythromycin and was tested for antibodies directed against Legionella pneumophila. The titers of these antibodies rose from 32 to 2048 after one month. The patient was cured.
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