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Biomedical subjects

E Young

Publications and source records attributed to E Young.

At least 235 records · Page 13Linked to original sources
PubMed1978

Thyroid hormone concentrations in a large scale community survey. Effect of age, sex, illness and medication.

Total thyroid hormone concentrations have been measured in the course of a large scale community survey to determine the distribution of these variables in the normal population and to assess the effect of age, sex, previously undectected thyroid disease and medication upon these parameters. 2779 subjects were studied. Serum T4 concentrations were normally distributed. A progressive increase in T4 levels with age was noted in the males, and a smaller increase in females which was concealed by the raised T4 values secondary to oral contraceptive therapy in females under the age of 45. Serum T3 levels were also normally distributed. There was a small reduction in T3 with age in the males but this fall was not seen in the females. T3 values were relatively higher in females under the age of 45 but this increase was not noted after exclusion of subjects taking an oral contraceptive. The changes in thyroid hormone concentrations with age are relatively minor (particularly with respect to T3) in a randomly selected sample from an English town. It is suggested that the changes reported by other authors reflect the process of selection used, and the high frequency of undetected thyroid disease, other illness and medication in hospital-based communities.

Adolescent↗
PubMed1977

The laboratory diagnosis of Sanfilippo disease.

The biochemical findings in 29 patients with Sanfilippo disease are reported and a scheme for laboratory diagnosis is outlined. A grossly elevated urinary excretion of heparan sulphate was a consistent and diagnostic finding, even at birth. The excretion of heparan sulphate and chondroitin sulphate was quantitatively similar in types A and B of the condition. Modifications of previously described methods for the determination of heparin sulphamidase in leucocytes or skin fibroblasts and N-acetyl-alpha-D-glucosaminidase in plasma or fibroblasts facilitated the measurement of specific activities. Sanfilippo A disease appeared to be the commonest mucopolysaccharidosis occurring in England and Sanfilippo B disease, one of the rarest forms.

Acetylglucosaminidase↗
PubMed1977

Effects of Quality, Intensity, and Duration of Light Breaks during a Long Night on Dormancy in Blue Spruce (Picea pungens Engelm.) Seedlings.

Blue spruce (Picea pungens Engelm.) seedlings grow continuously when exposed to photoperiods exceeding 16 hours and enter dormancy within 4 weeks under photoperiods of 12 hours or less. Dormancy was prevented under 12-hour photoperiods by 2-hour light breaks of red light (1.70 muw/cm(2) at 650 nm) or high intensity white light (2,164.29 muw/cm(2) at 400 to 800 nm) given in the middle of the 12-hour night, and by continuous low intensity white light (204.76 muw/cm(2) at 400 to 800 nm). Two-hour light breaks of far red light (1.80 muw/cm(2) at 730 nm), red light followed by far red light, or low intensity white light were not effective in delaying dormancy. The results imply that the phytochrome system mediates the photoperiodic control of dormancy in blue spruce seedlings. The similarity of results obtained using the low intensity, long duration as against the high intensity, short duration light treatments suggests that the law of reciprocity applies in this response.

Journal Article↗
PubMed1977

Animal dander allergy.

In a group of twenty-three atopic patients skin tests were performed with the dander allergens of horse, cat and guinea-pig, and with house dust and Timothy pollen allergens. A good agreement was observed between positive skin reactions and the results of RAST with these various allergens. In a number of cases, positive skin reactions were not related to the clinical histories. Likewise, positive RAST scores in several instances proved clinically meaningless. In patients with history-related skin reactions better correlation with RAST was observed. In such patients, skin reactions with photo-inactivated allergens remained strongly positive.

Allergens↗
PubMed1977

Juvenile Gaucher's disease with horizontal gaze palsy in three siblings.

Three children in a West African family had Gaucher's disease of juvenile onset (Type 3), and all showed an identical neurological disorder. The diagnosis was substantiated by histochemical demonstration of Gaucher cells in bone marrow, liver, and spleen, the finding of an excess of glucosyl ceramides in a liver extract, and a deficient activity of the enzyme beta-glucosidase in cultured skin fibroblasts. The neurological picture was characterised by myoclonic epilepsy, muscle wasting, hypotonia, pyramidal signs, some intellectual deterioration, and a striking disturbance of eye movements. The latter appears to result from specific involvement of the supranuclear pathways subserving lateral gaze. The distinctive features of this clinical syndrome are emphasised.

Age Factors↗
PubMed1977

Effects of immunologically induced growth hormone deficiency on myelinogenesis in developing rat cerebrum.

Chronic deficiency of growth hormone was produced in rats by injecting highly specific antibodies against rat somatotropin during the first week of postnatal life. Antisera were prepared by immunizing adult rhesus monkeys with purified rat growth hormone. The rate of body and brain growth was significantly decreased when compared with controls injected with nonimmune serum, and 50-day-old animals showed a profound and apparently specific endocrine deficiency of pituitary growth hormone as measured by bioassay. Defective cerebral maturation was evidenced by a 70 to 80 percent decrease of myelin lipids, a 65 percent reduction of deoxyribonucleic acid, and a small but significant decline in ribonucleic acid. An abnormal accumulation of undifferentiated glia was seen in the subependymal zone in association with decreased amounts of stainable myelin in subcortical white matter. The data suggest that pituitary growth hormone and/or its secondarily induced trophic factor, somatomedin B, influences the maturation of neural cells by regulating the replication of glia and the subsequent differentiation of oligodendrocytes to form myelin.

Age Factors↗
PubMed1977

Specific and non-specific skin test reactions with animal dander extract.

Intradermal skin tests have been performed in atopic patients with allergenic extracts of different animal danders at uniform concentration. A high incidence of positive test was recorded which could not be related to the clinical histories, especially with the allergens of horse, cow and dog dander (NR). Better correlation was observed with guinea pig and cat allergens (R). The incidence of NR reactions was highest in the house dust allergy group of patients; with the exception of horse dander allergen, the frequency of R reactions was more pronounced in the grass pollen group. It is suggested that both allergen-specific and non-allergen-specific mechanisms may contribute to positive wheal and flare reactions.

Allergens↗
PubMed1976

Effect of in vitro adaptation of Marek's disease virus on pock induction on the chorioallantoic membrane of embryonated chicken eggs.

Cell-associated preparations of several isolates of Marek's disease virus produced more pocks on the chorioallantoic membrane of embryonated chicken eggs than plaques in duck embryo fibroblasts, thus indicating that lesion response in eggs was more sensitive than cytopathic response in duck embryo fibroblasts for assaying low-passage Marek's disease virus. Adaptation of the virus to cell cultures by serial passages, however, substantially reduced its pock response so that the titer ratio (plaque-forming units in duck embryo fibroblasts/pock-forming units in eggs) of cell culture-adapted Marek's disease virus was 1 or higher. The decreased pock response could not be attributed to selection of preexisting virus variant(s) with low affinity for chorioallantoic membrane because cloned Marek's disease virus had a good pock response at low cell culture passage levels, but this response decreased as the virus was attenuated by serial cell culture passage.

Animals↗