Search PubMed⌕ Search

Biomedical subjects

E Wolner

Publications and source records attributed to E Wolner.

At least 397 records · Page 22Linked to original sources
PubMed1976

[Acute coronary surgery].

While the indications for surgical treatment of chronic angina pectoris are exactly defined, the delineation between conservative and surgical therapy of acute complications of coronary diseases is not standardized. The application of possible surgical procedures to acute coronary surgery (aorto-coronary bypass, infarctectomy, correction of post-infarction ventricular septal defects and mitral insufficiency) are discussed in relation to the following clinical pictures: 1. Unstable angina 2. Surgery after myocardial infarction a) recent infarction b) cardiogenic shock after infarction c) impending reinfarction d) post-infarction tachyarrhythmia unresponsive to conservative and electrical therapy e) acute heart failure caused by post-infarction defect of the ventricular septum or by mitral insufficiency. The following therapeutic guide-lines can be laid down on the basis of an analysis of experience gained in this field by other workers and ourselves: surgical therapy is indicated in the cases of unstable angina, impending reinfarction, or acute heart failure caused by a post-infarction ventricular septal defect or by mitral insufficiency which do not respond rapidly to conservatives measures. By contrast, the superiority of surgical intervention, even with the assistance of intraaortic balloon pumping, has not yet been established for the treatment of the remainder of the above-mentioned clinical pictures and requires evaluation by further investigations.

Angina Pectoris↗
PubMed1976

[A new design for a totally artificial heart: the ellipsoid heart (author's transl)].

Thromboembolic complications represent the main limiting factor in cardiac replacement by totally artificial hearts in calves at present. Thrombus formation within artificial hearts is caused by the appearance of stagnation areas. The ellipsoid heart eliminates stagnation areas by virtue of its production as a one-piece membrane. The heart is driven pneumatically and functions as a diaphragmatic blood pump. The stroke volume is 178 cm3 and the maximal cardiac output 15.8l/Min. Three acute experiments demonstrated a high degree of haemodynamic efficiency without compression of, or interference with surrounding structures, especially the inferior vena cava or the right atrium.

Animals↗
PubMed1976

[Myocardial bridge - cause of cardiac phase-dependent coronary stenosis (author's transl)].

A 41 year-old man presented with anginal pain and a positive exercise electrocardiogram. Hemodynamic and angiographic evaluation disclosed mild hypertrophic obstructive cardiomyopathy and a conic stenosis of the proximal left anterior descending artery confined to the systolic phase of the heart action. The degree of constriction of the coronary artery was no longer evident. Pathophysiologic consequences suggest that surgical dissection of muscle bridges should be considered in symptomatic patients with severe coronary obstruction.

Adult↗
PubMed1976

[Clinical experiences with cardioplegic injection in open heart surgery (author's transl)].

Two groups of 50 patients each who had undergone valve replacement with extracorporeal circulation, were examined. In the first group surgery had been performed only under coronary ischemia, whereas in the second group cardiac arrest was induced pharmacologically. IC CLUMP OCCURE MORE OFTEN. Also the amount of necessary defibrillation at occurrence of ventricular fibrillation was significantly lower. Besides it was extraordinary that after the cardiopulmonary bypass the consumption of positive inotropic drugs (Catecholamine) fsults injection-cardioplegia with its simple handling seemed evidently superior to coronary ischemia. But it remains to be seen, if injection-cardioplegia is equal to coronary perfusion.

Cardiac Surgical Procedures↗
PubMed1976

Production and diagnostic application of anti-human T-cell antisera.

This paper is intended to demonstrate the extension of experimental procedures used for the production of anti-chicken T-cell sera to the manufacturing of anti-human T-cell sera. Specific anti-chicken bursa (ABS) and anti-chicken thymus cell sera (ATS) were prepared in turkeys. The in vitro specificity of these sera was assessed by means of immunofluorescence and lymphocytotoxicity tests. The selective immunosuppressive effect of ABS was demonstrated in Obese strain (OS) chickens with spontaneous autoimmune thyroiditis, that of ATS in a skin allograft system. A specific anti-human T-cell serum was prepared by immunizing a horse with fetal human thymus cells. After appropriate exhaustive absorptions this serum was found to react specifically with human T-cells. An anti-T cell globulin (ATG) fraction prepared from the absorbed antiserum was then labelled with FITC for use in direct immunofluorescence tests. The potential diagnostic value of T-cell specific antibodies is discussed.

Animals↗
PubMed1975

[Partial replacement of the heart].

A ventricular-aortic blood pump was constructed for the functional replacement of the left heart. Hemodynamic experiments showed that the device was able to pump the total cardiac output in calves with a body weight under 85 kg. In these cases the myocardial oxygen consumption decreased to 40%. Laboratory findings in 5 longterm experiments revealed a complete adaptation of the body to the artificial organ up to 73 days.

Animals↗