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Biomedical subjects

E Witt

Publications and source records attributed to E Witt.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Anti-arrhythmic effect of dazolicin. Clinical-pharmacological research].

8-Chloro-6-[(1-isopropyl-3-imidazolin-2-yl)-methyl]-1,6-benzoperhydrothiazocin-hydrochloride (dazolicin, ucb B 192) is a new antiarrhythmic drug with direct membrane action which was applied both orally and parenterally. The immediate antiarrhythmic effect of a single i.v. injection of 150 mg of dazolicin on the average was investigated in 28 patients with various types of arrhythmia. After i.v. injection the drug proved to have very strong antiarrhythmic potency and rather a low incidence of side effects. Ectopic beats and paroxysmal tachycardias of both ventricular and supraventricular origin were successfully treated with dazolicin. The antiarrhythmic drug significantly increased the duration of both the QRS- and QT-interval after correction for frequency but it had no detectable effects on the atrioventricular conduction time. After i.v. administration the antiarrhythmic effects of the drug lasted for several hours. The elimination half-life of dazolicin was 7 h. Oral treatment with dazolicin was attempted in 10 patients suffering from stable extrasystolic arrhythmia with daily doses ranging from 3 x 25 mg to 3 x 50 mg. In only 4 patients ectopic beats could sufficiently be eliminated. According to the low dosage the maximum serum concentrations after oral application were significantly lower than after i.v. injection. In two patients serious side effects were observed, such as paroxysmal ventricular fibrillation and an increase in frequency and polymorphism of ventricular ectopic beats. In both instances the patients were suffering from congestive heart failure and they had TU abnormalities in the ECG.

Administration, Oral↗
PubMed1979

[The action of nitroglycerine on digitalis induced ST depression in patients with coronary disease (author's transl)].

The influence of therapeutic digitalisation on ST depression due to myocardial ischemia was investigated in 11 patients, average age 53.6 years, with coronary heart disease, compared with the effectiveness of nitroglycerine. Therapeutic digitalis led to an average increase of ischaemic ST depression from -0.53 to -0.73 mV. The mean pulmonary arterial and pulmonary capillary pressure decreased slightly, the frequency of pectanginous attacks increased. Independent of the digitalis effect nitroglycerine had an opposing action on these parameters. In decompensated patients with coronary heart disease (n = 4) both digitalis and nitroglycerine produced a shift of the left ventricular function curve as an expression of improved cardiac action. This could not be observed in patients with compensated ventricular function (n = 7). In sufficient ventricular function digitalis led to a further increase of myocardial ischaemic ST depression. In ventricular insufficiency no uniform behaviour was apparent. ST depression induced by digitalis could be reversibly influenced by nitroglycerine.

Adult↗
PubMed1978

[Treatment of hypertension with a combination of pyridopyridazine derivative with a beta-receptor blocker. Studies on the hemodynamic course (author's transl)].

22 pateints with a fixed, sometimes therapy-resistant (N = 18) hypertension were treated with a new antihypertensive agent, the pyridopyridazine derivative BQ 22-708 and hemodynamically investigated. 14 hypertensives received single oral doses of between 5 and 15 mg, 8 other patients also received additional treatment with a beta-receptor blocker (0.8 mg pindolol i.v.) or calcium antagonist (10 mg verapamil i.v.). In hypertension which is only poorly controllable or resistant, therapy with BQ 22-708 combined with beta-receptor offers a genuine alternative medication.

Adrenergic beta-Antagonists↗
PubMed1978

[Action of the calciumantagonistic compound gallopamile on sinus node, atrioventricular and intraventricular conduction (author's transl)].

The influence of the calciumantagonistic agent Gallopamile (D 600) on cardiac conduction and sinus node function was studied by using His bundle recordings and atrial stimulation in 13 patients with normal sinus rhythm. Intravenous administration of a single dose of 4 mg produced a significant increase in the atrioventricular conduction time by 30 %. On atrial stimulation second degree a-v block occurred at lower stimulation rates in all patients after Gallopamile. The impulse propagation in atrial tissue and within the His-Purkinje system was not affected, even in patients with diseased conduction system. There was an impairment in sinus node automaticity, the sinus node recovery time was increased by 58 % of the control value.

Adult↗
PubMed1977

[Evaluation of a pyridopyridazine as a drug with marked antihypertensive properties (author's transl)].

Compound BQ 22-708 is a pyridopyridazine with marked antihypertensive effects on experimentally induced hypertension. At this study hemodynamic reactions were controlled in 5 patients with resistent hypertension, two of them with the complication of hypertensive, two of them with the complication of hypertensive crisis, after oral administration of a mean dose of 11 mg BQ 22-708 (range 5 to 15 mg). Mean arterial pressure was reduced by 40 mm Hg. The onset of drug activity occurred 10 to 20 minutes after application. Maximum was reached after 90 to 180 minutes, whereas the antihypertensive effect lasted for about 5 to 6 hours. Peripheral resistance was reduced by about 50%. Heart rate and cardiac output increased. In patients with normal cardiac function stroke volume remained constant, whereas in patients with heart insufficiency an increase occurred. BQ 22-708 led to a slight reduction in pulmonary artery pressure and pulmonary capillary wedge pressure. Right atrial mean pressure remained unchanged. Additional treatment with a beta-adrenergic-blocking-agent or a drug with Ca-antagonistic-activities is indicated for inhibition of BQ-related increase of heart-rate.

Adult↗
PubMed1977

[Behaviour of the ST segment under stress by atrial frequency and digitalis in latent coronary insufficiency (author's transl)].

Therapeutic doses of digitalis may give rise to depressions and abnormities of the ST segment. In coronary patients this is occasionally also associated with anginal complaints. In 7 patients the ST segment was investigated at rest and under increasing stress by atrial frequency without and with digitalis at increasing therapeutic dosage. In all patients a glycoside-induced, linearly intensifying depression of the ST segment was demonstrated as a regular and dose-dependent pattern the onset of which was already recognizable at an average effective level of 0,59 mg digoxin. The opinion is held that glycoside-induced ST depressions in the ECG are not in general of insignificant nature but may be the reflection of myocardial ischemia.

Aged↗
PubMed1977

[Functional analysis in orthodontics and pedodontics].

The special examination of occlusion in the gnathological sense is less important for functional analysis in orthodontics and pedodontics. At the beginning of and during therapy, simple clinical examinations and observations provide the necessary diagnostic and prognostic information on the functioning of the individual parts of the masticatory system or their relation to each other. The clinical relevance of these findings was tested by electromyographic examinations, electronic pressure and volume measurements and tele- and cineradiographic tests. In the retention period, i.e. after therapy had been concluded, a gnathological examination was made in some cases in addition to the general functional analysis. The examination mainly centered on anatomic regions: lips, tongue, masticatory muscles, and temporomandibular joint. The following functions were examined: closing of the mouth, breathing, swallowing, speech, mandibular movements and the relation of rest position to habitual occlusion. In addition, general posture and habits like suckling and nibbling were studied.

Adult↗
PubMed1977

[Hemodynamic study on a new antihypertensive drug (a pyridopyridazine) in the treatment of hypertensive crisis and resistent hypertension. First findings in man (author's transl)].

Hypertension presents many unsolved therapeutical problems. On this reason further examinations on new antihypertensive agents are needed. BQ 22-708 is a pyridopyridazine with peripheral vasodilating activities, which has been shown in animal experiments marked antihypertensive properties of dihydralazine-type. A hemodynamic study revealed now similar effects in man, as could be demonstrated in 5 patients with resistent hypertension and additional hypertensive crisis in two cases. At these patients BQ 22-708 in doses between 5 and 15 mg reduced the mean arterial pressure by 48 mm Hg, but at the same time increased heart rate. Peripheral resistance was significantly reduced by 30-60%. Cardiac output increased. Stroke volume remained unchanged in patients without heart failure, but in those with cardiac insufficiency increased. There was a slight but non-significant reduction in pulmonary artery pressure and capillary wedge pressure, wheras right atrial pressure remained unchanged. The onset of drug activity was noticed 10-20 minutes after application of a single dose BQ 22-708 and lasted for about 5-6 hours. Therefore BQ 22-708 may prove to be useful in the therapy of resistent hypertension.

Adult↗