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Biomedical subjects

E Wilson

Publications and source records attributed to E Wilson.

At least 199 records · Page 11Linked to original sources
PubMed1976

Use of long-acting depot progestogen in domililiary family planning.

Medroxyprogesterone acetate injections have been used as a long-term contraceptive by the domiciliary family planning service in Glasgow. The injections were particularly useful in women with a high risk of becoming pregnant and in whom oral or intrauterine contraception had failed or was unacceptable. The optimum dose was 200 mg every 15-16 weeks. It was accepted by an increasing proportion of women, only 12 out of 162 discontinuing because of side effects. Continuation rates compared favourably with those for the pill, but less well than those for intrauterine contraceptive devices. The theoretical hazards should be weighed against the positive good resulting from controlled fertility in domiciliary patients.

Adolescent↗
PubMed1976

Serum luteinizing hormone, follicle-stimulating hormone, and testosterone responses to gonadotropin-releasing factor in males with varicoceles.

Five infertile males, ages 25 to 35, with oligospermia and varicocele had following gonadotropin-releasing hormone (LRF) infusion a rise of serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels which was not different from that of normal fertile males. The response of these hormones to LRF infusion was unaltered by spermatic vein ligation, but a significant elevation of the sperm count occurred. Thus, improvement in sperm count following spermatic vein ligation is not mediated via changes in peripheral gonadotropin or testosterone concentrations.

Adult↗
PubMed1976

[Effects of ketamine on the pressure of the cerebrospinal fluid. Variations of its effects].

Effects of chlorhydrate of Ketamine upon CSF pressure were studied in 10 patients with different intracranial pathology. In opposition to the results of other authors, in 5 patients there was no increase of pressure after the drug was applied. This difference is ascribed to the individual pathology of the patients studied, emphasizing that 4 of them were bearers of a diffuse vascular encephalopathy with intelectual damage, added to an acute vascular accident in 3 cases. For these reasons, it is presumed that a deficient auto-regulation of cerebral circulation, with diminished vasomotor reactivity, is reasponsible for the absence of hypertension after application of the drug. The study of the variations of cerebrospinal fluid pressure after chlorhydrate of Ketamine is applied may enable to measure the efficiency of the mechanisms of auto-regulation in any determined patient.

Adult↗
PubMed1976

[Spinomedullary compression caused by neurinomas and meningiomas].

A series of 30 spinal neurinomas and meningiomas studied in the Instituto de Neurología of Montevideo from 1958 to 1973 is analyzed. Seventeen neurinomas and 13 meningiomas are included. The following conclusions, in accordance with previous studies, were obtained from the clinical study and operative observations. Meningiomas were more commonly observed in females, in the sixth decade of life and were localized most frequently in the dorsal region. Neurinomas showed no preference for sex or site of the spine, and although they were more common in the sixth decade, they showed a greater dispersion in age. Clinical manifestations were similar in both groups but parasthesias were a more common initial symptom in meningiomas. Protein content of CSF was clearly greater in neurinomas. Radiological alterations of vertebrae were more frequently seen in neurinomas, but inespecific nature. Positive contrast mielography was in all cases useful for precise topographic diagnosis. Surgical results were satisfactory even in cases with severe preoperatory motor deficit.

Adolescent↗
PubMed1976

Cerebral hematomas.

One hundred patients with primary cerebral hemorrhage were studied to evaluate previously established guidelines for surgical treatment. Sixty two patients were not operated upon and 38 were. The mortality in the 100 cases was 51%. It appears that the mortality can be lowered if a careful selection of surgical cases is made.

Aged↗
PubMed1975

The von Willebrand syndrome.

Five patients with an original diagnosis of von Willebrand's disease are described because of their levels of factor VIII related protein, Ristocetin-induced platelet aggregation and/or family studies differed from the main group of patients with classical von Willebrand's disease. Two had normal levels of factor VIII related protein with reduced Ristocetin aggregation when this was tested in platelet rich plasma. In one, however, this was due to a plasma defect and in the other to a platelet abnormality. After cryoprecipitate infusion all abnormal tests were corrected in both these patients. The first patient, however, failed to show a secondary rise of factor VIII whereas the second showed a secondary rise of both factor VIII and of factor VIII related protein. The other three cases, who were all very severely affected, have been separated from the main group as none of their families was segregating for classical von Willebrand's disease. It is suggested that the term von Willebrand's disease should be confined to those patients who have reduced factor VIII related protein and Ristocetin aggregation, and that von Willebrand's syndrome should be used for the various sub-groups that are emerging.

Adult↗
PubMed1975

Effect of oral contraceptives on factor VIII clotting activity and factor VIII related antigen in normal women.

The factor VIII clotting activity (VIIIc1 and factor VIII related antigen (VIIIRAg) were determined repeatedly in 24 pairs of age-matched normal women, one of each pair being on oral contraceptives. No significant differences in either parameter or in the VIIIc/VIIIRAg ration were found between the two groups ,although the mean factor VIII clotting activity and VIIIc/VIIIRAg ratios for women on oral contraceptives were very slightly higher than for those not on oral contraceptives.

Adult↗
PubMed1975

Blood ethanol concentrations in patients attending special clinics in Glasgow.

Blood samples for measurement of ethanol concentration were taken on a routine basis from 543 male and 158 female patients attending Special Clinics in Glasgow. Ethanol was detected in 56 (10-3 per cent.) of the men and eight (5-1 per cent.) of the women, and at concentrations in excess of 0-1 g./l. in 37 (6-8 per cent.) and three (1-9 per cent.) respectively. In nine men and one woman, the blood ethanol concentration was over 0-8 g./l. when they attended the clinic. The majority (84 per cent.) of positive findings were obtained in specimens collected after 2 p.m. and one-quarter on Tuesday afternoons, the local half-day. The other peak periods related to attendance at football matches on Wednesday evenings, and to receiving wages on Friday mornings. Male new patients attending a clinic for the first time had the highest incidence, 32 (11-6 per cent.) having detectable amounts of ethanol among whom 26 (9-4 per cent.) had levels in excess of 0-1 g./l., compared with only 4-1 per cent. among those either returning to the clinics with a fresh infection or on surveillance. Only 5 per cent. of female patients attending for the first time and 3 per cent. of those on surveillance had detectable amounts of ethanol in the blood, compared with 9 per cent. of those few returning with fresh infections. Levels in excess of 0-1 g./1. were only found in promiscuous women. Those with concentrations in excess of 0-8 g./1. were unreliable attenders. Only one, a known alcoholic, completed surveillance; one defaulted after his fourth visit, four after the second, and four after the first visit.

Adolescent↗
PubMed1975

[Bilateral chronic subdural hematoma associated with hypotension of the cerebrospinal fluid].

A case is presented of a bilateral chronic subdural hematoma complicated in the post-operative evolution by a severe brain-stem suffering associated to a CSF hypotension andan angiographic descent of the brain-stem. The whole picture was made reversible by means of intrathecal injections of saline and the Trendelemburg position. The physiopathology of cerebral hypotension is discussed, considering it as an evolution process that implies both a diminution of the CSF and a descent of the brainstem. This process can be initially free of symptoms.

Adult↗
PubMed1974

Blood pressure in women taking oral contraceptives.

A controlled prospective survey of women taking oestrogen-progestogen oral contraceptives showed increases in mean systolic and diastolic blood pressure of 14.2 mm Hg and 8.5 mm Hg respectively after four years. The largest increases in individual cases were 36 mm Hg systolic and 20 mm Hg diastolic. Blood pressure returned to pretreatment levels within three months after oral contraceptives had been stopped. These changes in blood pressure were unrelated to the progestogenic potencies of the preparations being taken.

Adult↗