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E Weser

Publications and source records attributed to E Weser.

At least 55 records · Page 3Linked to original sources
PubMed1971

The metabolism of circulating maltose in man.

The utilization of circulating maltose was compared to that of glucose in six normal fasting subjects after intravenous injection of 25 g of either sugar. Blood samples were obtained over a 2 hr period and were assayed for free fatty acids (FFA), insulin, glucose, and total reducing substances. Urine was collected for 2 hr after maltose administration and assayed enzymatically for glucose and maltose. Blood glucose concentrations did not increase after maltose infusion, although a significant rise in total reducing substances was noted, indicating the presence of this disaccharide in the blood. Less than 3% of the administered maltose was excreted in the urine either as maltose or glucose. Initially, there was a fourfold increase in serum insulin concentration after glucose and a threefold increase after maltose infusion. Therefore, serum insulin concentrations gradually declined in a similar manner for both sugars. The plasma FFA at 15 min decreased 371 uEq/liter after glucose and 338 uEq/liter after maltose infusion. In other studies, 10 g maltose containing 5 muCi maltose-U-(14)C were injected into five human subjects and expired CO(2) collected for 6 hr. Maximal (14)CO(2) specific activity was noted at 170 min and a mean of 61.1% of the injected radioactivity was recovered as (14)CO(2). Less than 8% of the injected (14)C was excreted in the urine. These results indicate that maltose administered intravenously has similar metabolic effects when compared to glucose, and may be efficiently utilized as a carbohydrate substrate. The oxidation of intravenously administered maltose-U(14)C to (14)CO(2) demonstrates that circulating maltose is readily metabolized. A solution of maltose could provide twice the mass of sugar (and of calories) per milliliter as an equimolar solution of glucose. Parenterally administered maltose may be of clinical value and should be further studied.

Adult↗
PubMed1969

Malabsorption.

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Abetalipoproteinemia↗
PubMed1969

Studies of serum and tissue maltases in the rat.

Rat serum, kidney, and small bowel maltases were partially purified and chromatographed on columns of Sephadex G-200. Serum and kidney maltase migrated as early prominent peaks, whereas small bowel maltase separated into at least two and probably three peaks. No sucrase activity was present in either the serum or kidney peaks or in the first peak of small bowel maltase. The first maltase peak from small bowel and serum maltases had an optimal range of activity from pH 5.8 to 6.2. Kidney maltase activity was optimal at a narrow pH of 6.2. Heat inactivation studies suggested that at least two maltases were present in the chromatographic peaks of serum and kidney and in the first peak from small bowel. However, the velocity of inactivation of serum maltase differed from both kidney and small bowel maltases. Although serum, kidney, and some small bowel maltases may have similar chromatographic characteristics, the origin of serum maltase in the rat remains unclear.

Animals↗
PubMed1967

Metabolism of circulating disaccharides in man and the rat.

The metabolism of circulating disaccharides was studied in adult humans and rats. After iv infusions of 10 g of either lactose, sucrose, or maltose in four adults, no rise in blood glucose was noted. A mean of 8.7+/-1.89 g of the lactose and 6.3+/-1.39 g of the sucrose was excreted in the 24-hour urine sample. Only 0.11+/-0.03 g of the infused maltose was recovered in the urine, suggesting that the maltose was metabolized.After injection of (14)C-labeled lactose and sucrose in rats, 6.2+/-2.7 and 7.6+/-2.4%, respectively, was oxidized to (14)CO(2) in 24 hours; 62.1+/-13.5 and 68.4+/-10.8% of the respective disaccharides was excreted into the urine. Conversely, after injection of (14)C-labeled maltose 54.6+/-7.0% was oxidized to (14)CO(2) and 4.8+/-3.9% excreted in the urine. The per cent of maltose oxidized to CO(2) was similar to that of glucose. In addition to small intestinal mucosa, homogenates of rat kidney, brain, and liver as well as serum were found to have measurable maltase activities. The role of these tissue maltases in the metabolism of circulating maltose and maltosyloligosaccharides is discussed.

Animals↗
PubMed1966

Malabsorption.

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Humans↗
PubMedDate not supplied

Radiography of ileal adaptation in the rat following jejunectomy.

Six Sprague-Dawley rats were evaluated radiographically and histologically for adaptive changes in the ileum following total jejunal resection. Additionally, six rats were used as controls and six rats had sham operations. Marked hypertrophy of the ileum and hyperplasia of the mucosa with thickening of the ileal wall were documented in all six of the jejunectomized rats, compared with sham and unoperated controls. Radiographic changes were demonstrated in the bowel wall in three of six resected animals. These consisted of an irregular, serrated lumen that was normal to narrowed in caliber. No radiographic or histologic changes were seen in the control or sham rats. These results correlate radiographic changes with adaptive morphology of rat ileum after jejunal resection and resemble changes of adaptation seen in humans who have had jejunal-ileal bypass, jejunal resection, or nontropical sprue.

Adaptation, Physiological↗