Search PubMed⌕ Search

Biomedical subjects

E Werner

Publications and source records attributed to E Werner.

At least 217 records · Page 12Linked to original sources
PubMed1976

The effect of prindolol on plasma noradrenaline, plasma renin and sodium-potassium metabolism in patients with essential hypertension.

The chronic administration of prindolol in patients with essential hypertension resulted in the following: 1) a significant decrease in blood pressure and heart rate (with only the exception of the unchanged diastolic blood pressure after the stimulus of the seven-minute standing period), 2) a significant decrease of plasma noradrenaline concentrativn at rest and under orthostatic conditions, 3) a significant decrease of PRC at rest and an even more pronounced suppression of PRA after the stimulus of upright posture, 4)a significant decrease in total exchangeable sodium and 5) a concomitant significant increase in total body potassium even with an increase in body weight. These findings are not subject to easy interpretation. In particular, we cannot conclude which of the changed parameters plays the initial role in lowering blood pressure. A working hypothesis might presume that beta blocking agents inhibit central and/or peripheral sympathetic nervous activity. The results reduction in plasma renin concentration would in turn lead to a drop in aldosterone secretion rate indicated by the increase in potassium and decrease in sodiummour data would support such a sequence of events.

Blood Pressure↗
PubMed1976

[Intestinal absorption from therapeutic iron doses (author's transl)].

On a total of 105 persons with normal iron stores, iron depletion, and iron deficiency the intestinal absorption from therapeutic iron doses (100 mg Fe and 50 mg Fe as ferrous glycocoll sulphate) of a special galenic form was measured. The measurements were performed by means of a whole-body counter and preparations labelled with radio-iron (59Fe). Mean values of absorption rates from 100 mg Fe in healthy males were 5.0% and in healthy females 5.6% whereas in latent iron deficiency and in iron deficiency anemia mean values of 10% and 13% were obtained, respectively. The maximum absorption rate of 20 to 25% is reached already in the late stage of latent iron deficiency. Advancing severeness of iron deficiency is not followed by an increase of iron absorption. Investigations on 21 persons showed no significant difference between absorption rates of the galenic preparations used when administered orally before or after breakfast, respectively.

Anemia, Hypochromic↗
PubMed1976

Occult blood loss and iron balance in chronic renal failure.

In 38 patients with chronic renal failure total daily blood loss and intestinal iron absorption were determined by means of a whole-body counter and radioiron. Bone marrow iron content was measured histochemically. Mean daily blood loss (corrected for laboratory blood sampling) and iron absorption were significantly higher than in normal controls. Bone marrow iron content was reduced in 46% of the patients. The results prove that gastrointestinal blood loss in patients with chronic renal failure is of such magnitude that negative iron balance results.

Absorption↗
PubMed1976

On the pharmacokinetics of rifampicin during treatment with intermittent administration. II. Influence of age and sex and of the patients.

Pharmacokinetic investigations in 75 patients receiving their first treatment for infectious lung tuberculosis gave the following results: RMP and its products of biotransformation are excreted via the urine in smaller amounts in patients above 55 years than in younger patients. In the older age group the induction phase - as measured by the urinary excretion of RMP - is also more marked than in younger patients. Both the serum RMP-concentration and the urinary excretion of RMP are significantly higher in women than in men. The sex specific differences in pharacokinetics seem to be of clinical importance. Because of the higher serum RMP-concentration it is possible to reduce the RMP-dosage 10% in female patients, even with intermittent administration, and to diminish the risk of dose-dependent side effects.

Adolescent↗
PubMed1975

Recurrent T.R.I.C. kerato-conjunctivitis: treatment with tetracycline.

Trachoma inclusion conjunctivitis agent infections have a spectrum of clinical presentations which in their more chronic forms are often difficult to recognize. Patients with epithelial erosions of the upper cornea, episodic E.K.C. type subepithelial infiltrates, pannus or micropannus, and with or without lid scarring, merit conjunctival scrapings as an aid to diagnosis. Since the agents which produce these infections have a genital reservoir, as the prevalence of venereal diseases increases, the incidence of this type of keratoconjunctivitis will also increase. If the diagnosis is suspected treatment with systemic tetracycline is effective and relatively safe. Simultaneous treatment of sexual consorts of inclusion conjunctivitis patients and families of trachoma patients should decrease recurrences.

Adult↗
PubMed1975

[The serum and uterine muscle concentrations of Cephradin and Cephalothin].

On the day of operation 2 grams of Cephradin was given intravenously to 33 patient and 2 grams of Cephalothin was given intravenously to 31 patients. At various time intervals, uterine tissue and serum was removed. The mean serum concentrations of Cephradin were 3 times higher and the mean tissue concentrations of Cephradin were 7-8 times higher than the corresponding concentrations of Cephalothin. Because of the difference in protein binding of the examined cephalosporins (Cephradin 6%, Cephalothin 60-65%) the difference for the antimicrobially active portion (Protein free portion) is even more favorable for Cephradin. The significance of these pharmacokinetic differences for the treatment are obvious.

Adult↗
PubMed1975

[The reaction of the secretory elements of the mucosa of the upper respiratory tract from physiological and pathophysiological aspects (author's transl)].

The main function of the secretory elements of the mucosa of the upper respiratory tract - endoepithelial beaker cells and complex glands, exoepithelially situated - is surface defense. From this point of view ciliary system and secretion form a functional unit. Disorders of the synergism of the components may irreversible change the structure of the mucosa as demonstrated e.g. by the chronic forms of inflammation, when the limits of compensation are exceeded. The interrelation between epithelium and lamina propria are explained on the basis of histochemical evidence from normal and pathological mucosa of the upper respiratory tract. The metabolic processes between the vascular system and the cells form the basis of the normal as well as pathological secretion of the mucosa.

Electron Transport Complex IV↗