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Biomedical subjects

E Wenzel

Publications and source records attributed to E Wenzel.

At least 163 records · Page 9Linked to original sources
PubMed1980

[Computer-tomographic diagnosis of the traumatised pelvis (author's transl)].

Eighteen patients with fractures of the pelvis were examined by computer tomography. The results were compared with those of conventional radiological diagnosis. In each case the bone injuries were accurately diagnosed, in some patients additional information was obtained or the findings corrected. It was also possible to demonstrate injuries to pelvic, abdominal and retroperitoneal organs and injuries to other regions of the body, such as the skull and thorax. Haematomas could be directly demonstrated and additional information, useful for plannng surgery, was obtained.

Acetabulum↗
PubMed1979

[Sulfamethoxazole concentration in the homogenate of the human embryo].

The investigations on the extent of placental drug transfer has conventionally been based on determining drug concentration in cord blood at delivery. There is, however, data that levels in cord blood at delivery may provide misleading information on the extent of drug transfer in utero. It is due to the fact that not every drug reaches the fetus in pharmacologically active form. Hence, the evaluation of placental drug transfer requires determination of free drug concentration in fetal tissues. Seven women with indications for interruption of pregnancy for social reasons have taken Biseptol 480--Polfa (400 mg sulfamethoxazole and 80 mg trimethoprim) for 4-5 days before the operation. Each woman received 1,92 g of drug (4 tablets) a day in two divided doses. In the tissues obtained during abortion, the concentration of sulfamethoxazole was estimated by the modified method of Bratton and Marchall . The obtained results show that in the first trimester of gestation sulfamethoxazole crosses human placental barrier; it is detectable in embryo in a great amount. This fact indicates that administration of Biseptol to the pregnant mother may be harmful for the embryo. Our investigations have not permitted yet on for the statement that there is the correlation between the sulfamethoxazole concentration and week of gestation during the first trimester.

Biological Transport↗
PubMed1979

[CT scanning in cystic liver changes (author's transl)].

Computer tomography is outstandingly suitable for detecting cystic processes in the liver. The genesis of such cysts can vary widely, so that there are bound to be differences in the clinical relevance of the findings. This is discussed on the basis of 20 case histories of cystic changes of the liver observed during one and a half years. For the purpose of discussion of the value of CT scanning, comparisons with sonographic and angiographic examinations were carried out.

Adult↗
PubMed1978

[The radiological diagnosis of gastro-intestinal metastases from malignant melanomas (author's transl)].

Amongst 240 patients with histologically proven metastases from malignant melanomas, there were 17 cases with gastro-intestinal involvement; of these there were seven in the small bowel, five in stomach, two with multiple deposits in stomach and small bowel and one in the colon. In four patients there were deposits in the mesentery or peritoneum. Radiologically these appeared as sharply demarkated polypoid intraluminal contrast defects with central ulceration (target lesions). In the cases with known primary tumours and multiple deposits, there were no problems regarding the differential diagnosis. Accurate radiological demonstration of metastases from malignant melanomas in the gastrointestinal tract or retroperitoneal space is of importance in order to avoid extensive surgery.

Adult↗
PubMed1977

[Diagnostic therapeutic problems of defibrination syndrome in shock, sepsis, and neonatal hypoxia (author's transl)].

The diagnosis of defibrination syndrome in shock, sepsis and neonatal hypoxia is based, in addition to the clinical picture, upon a few parameters of the hemostatic system, which, in part as global tests, provide information about the course of coagulation. The parameters measured are partial thromboplastin time, thromboplastin time, plasma thrombin time, fibrinogen, thrombin-coagulase and reptilase times as well as platelet count. Normal values of these laboratory parameters were established for healthy newborns 1--5 days of age, and for healthy adults. It is suggested that especially partial thromboplastin time, the thrombin-coagulase and reptilase times, the latter influenced by fibrinolysis cleavage products, are representative for the tentative diagnosis of disseminated intravascular coagulation with fibrinolysis syndrome (DICFS). The platelet fall often lags 1--2 days behind the event. Moreover normal values for newborns, are markedly higher than those for older children or adults. In the presence of DICFS, a low-dose heparin therapy is immediately initiated. If completed defibrination is manifest, therapy is supplemented with urokinase and streptokinase, For DICFS with congenital sepsis, an exchange transfusion with heparinized fresh blood is the treatment of choice.

Asphyxia Neonatorum↗
PubMed1976

[The effect of cerebrolysin on chronic encephalopathy. An experimental psychological and electroencephalographic study (author's transl)].

The results obtained with the cerebral hydrolysate Cerebrolysin in 33 patients (22 men, 11 women) with chronic encephalopathy are reported. 11 patients received one and 22 patients two courses of 10 ampoules i.m. The results of neurological, psychiatric, echoencephalographic, electroencephalographic and experimental psychological investigations were compared by means of a battery of 6 single tests before, during and after the individual treatment series. A marked influence on the basic rhythm, slight focal changes and also general changes were established. In the experimental psychology field, the rate of improvement was 78.5%.

Adult↗
PubMed1975

[Influence of a streptokinase-induced fibrinolysis on the extent of the acute experimental myocardial infarction (author's transl)].

In 17 unaesthetized dogs several side branches of the left descending coronary artery were ligated. The ST-segment elevation in the epicardial ECG ascended to 22 mV after 5 min and to 19 mV after 20 min. Aortic pressure, left ventricular enddiastolic pressure, heart rate and hemostasiological parameters (thrombin-time, thrombin-coagulase-time, reptilase-time, plasma-fibrinogen, staphylococcal clumping test) did not change significantly. 20 min after the beginning of coronary occlusion, the vessels were reopened. When ST-segment elevation had disappeared, a controlled fibrinolytic therapy (Streptokinase 1.5 Mega I.E. in 30 min, later on 0.75 Mega I.E./h) was induced. When an effective fibrinolysis could be demonstrated by the hemostasiological parameters, the same vessels were occluded again. Now the hemodynamic parameters too did not change significantly, but the ST-segment elevation was significantly diminished for more than 50% compared with simple ligation. A control group, which only got the solvent of the streptokinase, showed the same ST-segment elevation. This effect, induced by streptokinase is ascribed to fibrinogen degradation products and a diminution in the amount of fibrinogen which cause an improvement of microcirculation.

Animals↗
PubMed1975

[Value of physiological coagulation parameters in perioperative consumption coagulopathy using low heparin doses].

In the course of extensive operations there are disturbances of the turnover-rate because of the activation of the clotting-system. These may equally be demonstrated by simple reproducible and quick global tests as by methods which are expensive and reserved only to special laboratories. By consequent low dosis-heparin-medication hypercoagulability-conditions and reactive hemorrhage complications are prevented and the hemostasis situation is significantly improved. No disturbance of the hemostasis by antithrombin-3-effect of the heparin-application in this dosage can be proved. The results of the examination including quality control and interpretation can be obtained in 30 minutes.

Blood Coagulation Tests↗