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Biomedical subjects

E Wei

Publications and source records attributed to E Wei.

50 records · Page 3Linked to original sources
PubMed1973

Morphine analgesia, tolerance and physical dependence in the adrenalectomized rat.

1. Adrenalectomy reduced the median antinociceptive dose (AD50) of morphine in male Sprague-Dawley rats. The antinociceptive effect was assessed by the tail-flick method of D'Amour & Smith (1941).2. Tolerance to the antinociceptive effect of morphine developed in adrenalectomized and sham-operated rats after chronic exposure to morphine. Development of tolerance did not significantly alter the increased sensitivity of adrenalectomized rats to the antinociceptive effect of morphine.3. Adrenal weights were not increased in rats rendered physically dependent on morphine by subcutaneous implantation of a morphine pellet. Withdrawal, induced by intraperitoneal injection of naloxone hydrochloride, 4 mg/kg, or by removal of the implanted pellet, resulted in a rapid increase in adrenal weight.4. In morphine-dependent animals, the incidence of abstinence signs and body weight loss during precipitated withdrawal did not appear to be significantly influenced by adrenalectomy or by corticosterone-pretreatment.

Adrenal Glands↗
PubMed1972

Neuroanatomical correlates of morphine dependence.

Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.

Animals↗
PubMed1971

Methylmercury poisoning. An assessment of the sportfish hazard in California.

A quantitative assessment of the methylmercury risk in California entails measurement of the contamination distribution, the probability of methylmercury intake and knowledge of the toxicological properties of methylmercury. This article reviews the scientific basis for the California State Task Force's decision to warn the public against excessive consumption of sport fish contaminated by methylmercury.

California↗