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Biomedical subjects

E Walcz

Publications and source records attributed to E Walcz.

25 records · Page 2Linked to original sources

Lymphocyte subpopulations in peripheral blood of small-for-gestational age and appropriate-for-gestational age preterm neonates.

The lymphocyte subpopulations were investigated in peripheral blood of small-for-gestational age (SGA) and appropriate-for-gestational age (AGA) preterm newborns. In SGA newborns the number and percentage of T lymphocytes were reduced. Among the T lymphocytes, the number and percentage of T helper cells were significantly decreased. The cytotoxic/suppressor T cells were also reduced, but to a lesser extent.

Birth Weight↗

Developmental changes in lymphocyte surface markers.

The aim of the study was to establish normal values for TG and TM cells in neonates and small babies who are more susceptible to infections than children and adults. For the same reason, the T- and B-lymphocyte ratios were also determined. The percentage of B- and T-cells in neonates was significantly lower, while their absolute number higher, than the adult value. The percentage of TG cells was significantly higher in neonates than in the other age groups. There was a significant decrease in the ratio of TM cells as compared to adult values. Spontaneous thymidine uptake showed an inverse correlation with age, but the difference was not significant. There was a nearly identical response to PHA in the observed age groups, at least to the single dose of PHA applied.

Adolescent↗

Effect of two synthetic alpha-gliadin peptides on lymphocytes in celiac disease: identification of a novel class of opioid receptors.

Two synthetic peptides containing residues 43-47 and 43-49 of alpha-gliadin were tested for inhibition of leukocyte migration in 47 patients with celiac disease. In nineteen patients, all on a normal diet, leukocyte migration was inhibited by the peptides and naloxone blocked this effect. In twenty-eight patients (24 of whom were on strict gluten-free diet) leukocyte migration was not affected by the peptides. Our results suggest that alpha-gliadin-(43-49), Tyr-Pro-Gln-Pro-Gln-Pro-Phe, is closely related to the active fragment, or to one of the active fragments of alpha-gliadin, and that it interacts with receptors that are similar to but not identical with the known opiate receptors.

Adolescent↗