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Biomedical subjects

E W Wielinga

Publications and source records attributed to E W Wielinga.

12 recordsLinked to original sources
PubMed2001

Middle ear effusions and structure of the tympanic membrane.

OBJECTIVE: To study the effect of various middle ear effusions on the structure of the lamina propria of the tympanic membrane. METHODS: Sterile and infective middle ear effusions were induced by obstruction of the eustachian tube in specific pathogen-free (SPF) rats and in rats with upper airway infections (URI), respectively. The condition of the tympanic membrane was monitored at regular intervals. After varying survival times, the animals were killed and the tympanic membranes processed for light and electron microscopy. RESULTS: Sterile effusions always resulted in tympanosclerotic lesions. These lesions did not develop in the presence of primary-infected effusions. These effusions had a severe destructive effect on the lamina propria, followed by fibrosis. Generally, secondary infection did not markedly affect preexisting tympanosclerotic lesions. Moreover, calcification disappeared when re-aeration of the middle ear occurred, but the abnormal collagen depositions persisted. CONCLUSIONS: Both sterile and infective effusions result in comprehensive irreversible changes in the lamina propria of the pars tensa. The development of tympanosclerosis is confined to sterile effusions. Mechanical injury and compromised vascularization of the lamina propria are likely to be important etiological factors in the development of tympanosclerosis.

Animals↗
PubMed2000

A solitary manifestation of mastocytosis in the head and neck.

Solitary mastocytosis in adulthood is a rare finding. Only two such lesions have been reported in the head and neck. We describe a 27-year-old woman who had a 10-year history of a forehead swelling that had fluctuated in size. Light trauma or pressure on the lesion resulted in an increase in its size. A mass was found to be situated just below the galea and was successfully removed surgically using a high forehead lift. Histologically, the specimen contained predominantly mast cells. A systemic mastocytosis was excluded by a multidisciplinary diagnostic approach and measurement of the 24-h urinary excretion of histamine metabolites. After 36 months of follow-up there has been no recurrence.

Adult↗
PubMed1998

The effects of computer simulated facial plastic surgery on social perception by others.

Previous studies have demonstrated the remarkable impact of facial plastic surgery on the perception of facial features. However, pre- and postoperative differences other than the surgically changed features such as facial expression, hairstyle, make-up etc., have influenced the results of previous studies. To exclude these visual cues a computer composite photograph of the changed feature mounted upon the preoperative photograph, instead of the standard postoperative photograph, was presented to observers in this study. Computer graphic technology was used to superimpose the postoperative, surgically changed facial features such as the nose, ear and chin of 16 patients on standardized preoperative photographs. The randomized preoperative photographs and the 'postoperative' composed images were presented to 67 subjects, using a person-perception questionnaire. Multivariate analysis demonstrated a more favourable postoperative judgement in only two patients (12.5%). The exclusive effect of facial plastic surgery on the social perception of patients by others when excluding visual cues, such as facial expression, hairstyle, make-up etc, is limited. It is tentatively assumed that the role played by facial plastic surgery is one of initiating a positive cycle by changing the patient's self-perception rather than one of direct social impact from the changed features.

Adolescent↗
PubMed1995

Tympanosclerosis in the tympanic membrane: influence on outcome of myringoplasty.

The effect of the presence of tympanosclerotic plaques in tympanic membrane on the outcome of a myringoplasty procedure was evaluated in this retrospective study. Long-term results of 714 myringoplasties were analyzed, and of these, 555 were eligible for further study. Three groups were studied separately: ears without tympanosclerosis, ears with a plaque not exceeding one third of the tympanic membrane surface area, and ears with a plaque involving more than one third of the surface area extending to the border of the perforation. The latter group was subdivided into one in which during the operation the plaque was removed and one in which it was left in place. Take rate percentages as well as postoperative hearing results were calculated for each separate group of ears. Concerning graft take rate, it is concluded that the presence of tympanosclerosis in the tympanic membrane played no substantial part in the long-term outcome. With regard to postoperative hearing results, however, this study shows an average hearing gain of 6 dB when plaques exceeding one third of the tympanic membrane surface area were removed as part of the myringoplasty procedure.

Adolescent↗
PubMed1993

Tympanosclerosis.

Explore the source record for details and available documents.

Cholesteatoma↗
PubMed1992

Rhinosporidiosis in Europe.

Rhinosporidiosis is an inflammatory disease of the nasal mucosa caused by Rhinosporidium seeberi. The disease is endemic in India but very rare in Europe or other continents. The literature concerning aetiology, clinical appearance, morphology and treatment is reviewed. All reported European cases are summarized.

Child↗
PubMed1990

Comparison of the Goode T-tube with the Armstrong tube in children with chronic otitis media with effusion.

Treatment of otitis media with effusion is focused on reaeration of the middle ear cavity. In achieving long-term aeration, the insertion of ventilation tubes that have a long duration of stay can be beneficial. The results are presented of a trial in which the Goode T-tube was compared with the Armstrong tube. Fifteen children were treated between 1981 and 1986 with a T-tube in one ear and a conventional tube in the other. The results are different with regard to duration of stay in the tympanic membrane. Re-insertions were necessary in 47 per cent in the Armstrong group and in 20 per cent in the T-tube group. Otorrhoea occurred in 20 per cent of the Armstrong and 13 per cent of the T-tube intubated ears. A persistent perforation was present in 6 per cent of the ears in both groups. It is concluded that the Goode T-tube is indicated primarily in cases when long-term ventilation is needed.

Child↗
PubMed1989

Long-term results of sacculotomy in older patients.

In patients with Meniere's disease with incapacitating vertiginous complaints in whom medical treatment has failed, sacculotomies by both the Fick and tack operations are relatively simple surgical procedures, whose short duration of anesthesia and hospitalization of patients minimizes the risks of morbidity in older patients appropriately to their general health, with good results in controlling vertigo. With respect to preservation of hearing, the tack operation is superior to the Fick operation.

Adult↗
PubMedDate not supplied

An experimental model for tympanosclerosis. A preliminary report.

This study deals with an animal model where tympanosclerosis could be evoked with high reproducibility during the course of a sterile otitis media, induced by Eustachian tube obstruction. The histopathological features of this induced lesion were very similar to those reported in human specimens. It was concluded that this process is most probably triggered by a mechanical deformation of the tympanic membrane.

Animals↗