Biomedical subjects

E W Friedman

Publications and source records attributed to E W Friedman.

At least 37 records · Page 2Linked to original sources

PubMed1982

The place of fine needle biopsy in the diagnosis of nodules of the thyroid.

Fine needle aspiration cytology with an accuracy rate of 90.2 per cent confirmed by surgical specimens was found to be a useful adjunct in the diagnosis of tumors of the thyroid but did not replace large needle core biopsy. Both methods offered information complementary to each other, and our data indicated that, when possible, they should be used together. Although both false-positive and false-negative results were reported with fine needle cytology aspiration biopsy, it was the false-negative reports which limited its use as a definitive diagnostic tool. Fine needle aspiration biopsy, however, did constitute a safe and useful method of increasing diagnostic ability in the evaluation of thyroid nodules.

Adult↗

PubMed1977

Patency of venous grafts in small veins: influence of aspirin and warfarin sodium.

Venous autografts were prepared in jugular veins of rabbits as a test model to determine the usefulness of antiplatelet and anticoagulant agents (aspirin and warfarin sodium) alone or in combination for maintaining patency in the reconstruction of small veins. Graft patency was determined by periodic venography and postmortem examination. The grafts clotted in all of the untreated controls, five of six animals receiving aspirin, and three of four receiving warfarin, but in none of the animals receiving the combination of aspirin and warfarin.

Animals↗

PubMed1976

Evidence suggesting the regulation of a coagulation factor levels in rabbits by a transferable plasma agent.

New Zealand white rabbits were given 30 ml of goat serum intravenously. This procedure resulted in an immediate decrease in platelet count, fibrinogen, and levels of coagulation factors II, V, VII, and X, due to consumption coagulopathy. These factors returned toward baseline levels approximately 12 hr after the injection. Plasma from rabbits who had received goat serum 48 hr previously (donor rabbits) was injected into recipient rabbits. This procedure resulted in a slight rise in the level of coagulation factor II (range, 20%-30%) and a significant rise in factors V (35%-75%), VII (35%-235%), and X (35%-75%) in the recipients. When plasma from control donor rabbits who had not received goat serum was injected into recipients, there was no change in these coagulation factors. It is postulated that the reduction in coagulation factor levels in donor rabbits induces a "coagulopoietin" for each factor or one "coagulopoietin" for all factors which stimulates increased synthesis and/or release of these factors in recipient rabbits.

Animals↗

PubMed1976