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Biomedical subjects

E Vogel

Publications and source records attributed to E Vogel.

At least 73 records · Page 4Linked to original sources
PubMed1989

Behavioural effects of the benzodiazepine receptor partial agonist RO 16-6028 in mice.

The imidazo-diazepinone RO 16-6028 is a benzodiazepine receptor partial agonist which exhibits some anti-conflict effects in the two-chambered light/dark test without significantly affecting the behaviour of mice confronted with the staircase test. In addition, this drug slightly reduced locomotion and more markedly rearing in a free exploration procedure. These results indicate that RO 16-6028 appears to produce some anxiolytic and sedative properties like full agonists, but with weaker magnitude. This could be related to the benzodiazepine partial agonistic profile of the compound.

Animals↗
PubMed1988

Benzodiazepine antagonist RO 15-1788 partly reverses some anxiolytic effects of ethanol in the mouse.

The effects of the benzodiazepine (BZD) receptor antagonist RO 15-1788 (3 mg/kg) on the anxiolytic properties of ethanol in mice confronted with a light/dark choice procedure and with the staircase test were investigated. RO 15-1788 reversed the effects of ethanol on some of the behavioural parameters without eliciting intrinsic effects when given alone. These data closely resemble those we previously obtained with several BZD receptor inverse agonists such as RO 15-3505, RO 15-4513 or beta-CCM. Since anxiogenic-like properties of low doses of RO 15-1788 have been identified by other authors, it is suggested that the antagonistic action of this drug against some of the behavioural effects of ethanol could be due to its being a partial BZD inverse agonist.

Animals↗
PubMed1988

Interaction of RO 15-4513 and ethanol on the behaviour of mice: antagonistic or additive effects?

Opposite effects were observed of ethanol on the behaviour of mice in the two chambered light/dark test. At a low dose, it had anxiogenic effects, while it produced anxiolytic effects at a higher dose. Selective antagonistic actions of RO 15-4513 against the behavioural effects of ethanol have been reported by others without intrinsic actions. In contrast, we found intrinsic depressive properties of RO 15-4513. This drug reduced locomotion in a running wheel test. We suggest that RO 15-4513 reversed certain effects of ethanol in an additive, rather than interactive, manner. In addition, RO 15-4513 did not block the sedation produced by a high dose of ethanol. Since RO 15-4513 revealed proconvulsant properties, it is proposed that the depressive effects of this drug could be related to its proconvulsive activity.

Animals↗
PubMed1988

The benzodiazepine receptor inverse agonists beta-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice.

The antagonistic effects of the benzodiazepine receptor inverse agonist beta-CCM (1 mg/kg) and of the partial inverse agonist RO 15-3505 (3 mg/kg) on the anxiolytic properties of ethanol (1 g/kg) in mice confronted with a light/dark choice procedure and with the staircase test were investigated. Both drugs reversed the effects of ethanol on some of the behavioral parameters, but beta-CCM alone elicited anxiogenic intrinsic effects. RO 15-3505 induced seizures in mice treated with a subconvulsant dose of pentylenetetrazole, the most efficient doses being 3 and 6 mg/kg. These data indicate that beta-CCM and RO 15-3505 can reverse some of the anxiolytic effects of ethanol, acting probably to oppose GABA function via the benzodiazepine receptor.

Animals↗
PubMed1988

Does RO 15-4513 reverse the anxiolytic effects of ethanol by its intrinsic properties?

In order to better understand the antagonistic effects of the partial inverse agonist of benzodiazepine receptors, RO 15-4513, against the disinhibitory action of ethanol, we examined the effects of RO 15-4513 at a dose (2.0 mg/kg) that did not alter locomotor activity, given alone or in combination with ethanol, on the behavior of mice confronted with the light/dark choice procedure and the staircase test. At this dose, RO 15-4513 given alone was found to have slight anxiogenic properties and when given in combination with ethanol, to completely reverse the disinhibitory effects of ethanol. Since we previously observed postictal depression after higher doses of RO 15-4513 given alone and antagonistic effects of these same doses on the action of ethanol, it can be suggested that the antagonistic effects of RO 15-4513 against ethanol are due to its anxiogenic or depressive properties depending on doses. However, this hypothesis can only be regarded as being in early stages of development at the present time since these results do not parallel with those of several other studies and the question whether the antagonistic action of RO 15-4513 against ethanol is additive or interactive remains open.

Animals↗
PubMed1987

Anxiogenic effects of methyl-beta-carboline-3-carboxylate in a light/dark choice situation.

Doses of benzodiazepine, clorazepate, and also of the inverse agonist of the benzodiazepine receptor, beta-CCM, which failed to present sedative or postictal depressive effects, were at first determined in a free exploratory situation. Then, the effects of clorazepate dosed at 1.0, 2.0 and 4.0 mg/kg and beta-CCM dosed at 1.0 and 2.5 mg/kg were studied in the light/dark box choice procedure. Clorazepate tended to produce an increase of the time spent by mice in the lit box as well as of the number of transitions between the two boxes, whereas the dose of 1.0 mg/kg of beta-CCM had opposite effects. The benzodiazepine antagonist RO 15-1788 completely counteracted the anxiolytic effects of clorazepate dosed at 2.0 mg/kg and the anxiogenic effects of beta-CCM.

Animals↗
PubMed1987

[The superior laryngeal nerve and the superior laryngeal artery].

Length, diameter and anastomoses of the nervus vagus and its ganglion inferius were measured 44 halved heads. On the average, 8.65 fiber bundles of the vagus nerve leave the retro-olivary area. In the area of the jugular foramen is the near superior ganglion of the 10th cranial nerve. In this area were found 1.48 (mean value) anastomoses with the 9th cranial nerve. 11.34 mm below the margo terminalis sigmoidea branches off the ramus internus of the accessory nerve which has a length of 9.75 mm. Further anastomoses with the 10th cranial nerve were found. The inferior ganglion of the 10th nerve had a length of 25.47 mm and a diameter of 3.46 mm. Five mm below the ganglion the 10th nerve had a width of 2.9 and a thickness of 1.5 mm. The mean length of the superior sympathetic ganglion was 26.6 mm, its width 7.2 and its thickness 3.4 mm. In nearly all specimens anastomoses of the superior sympathetic ganglion with the ansa cervicalis profunda and the inferior ganglion of the 10th cranial nerve were found. The superior laryngeal nerve branches off about 36 mm below the margo terminalis sigmoidea. The width of this nerve was 1.9 mm, its thickness 0.8 mm on the right and 1.0 mm on the left side. The division in the internal and external rami was found about 21 mm below its origin. Between the n. vagus and thyreohyoid membrane the ramus internus had a length of 64 mm, the length of external ramus between the vagal nerve and the inferior pharyngeal constrictor muscle was 89 mm. Its mean length below the thyreopharyngeal part was 10.7 mm, 8.6 branchlets to the cricothyroid muscle were counted. The superior laryngeal artery had its origin in 80% of cases in the superior thyroideal artery, in 6.8% this vessel was a branch of the external carotid artery. Its average outer diameter was 1.23 mm on the right side and 1.39 mm on the left. The length of this vessel between its origin and the thyreohyoid membrane was 34 mm. In 7% on the right side and in 13% on the left, the superior laryngeal artery reached the larynx through a foramen thyreoideum. Ranges of diameters and lengths of vessels and nerves in the larynx are given.

Arteries↗
PubMed1986

Reduction of neophobia in mice following lesions of the caudate-putamen.

Electrolytic lesions of the caudate-putamen result in a significant decrease in neophobic responses in mice towards a novel object introduced into their familiar environment; however, preference for a novel environment was not altered by the lesion. These data provide a parallel between the effects of lesions of the caudate-putamen and the well-known "amygdala-lesion-syndrome." It is suggested that the striatal complex, which receives massive afferent projection systems, plays a crucial role in sensory-motor integration processes which allow the animals to adapt their responses towards biological significant stimuli in order to cope with their environment.

Animals↗
PubMed1986

[Radiation exposure of the surgeon in percutaneous nephrolithopaxy ].

Radiation exposure to the surgeon was determined during 50 percutaneous renal stone removals. Above-table X-ray equipment with the X-ray tube in a vertical position was used. The beam was always collimated to 15 cm X 15 cm. A vertical lead screen between surgeon and X-ray tube offered protection against scatter radiation. Radiation exposure to the left hand ranged from 0.1 mSv to 4.7 mSv (average: 0.92 mSv); to the right hand from 0.1 mSv to 1 mSv for one operation (average: 0.26 mSv). Chest dose (under and outside the lead apron) was in 50 cases lower than 0.01 mSv. Radiation exposure at collar level was in 45 cases lower than 0.01 mSv and averaged 0.08 mSv in 5 cases (range: 0.05 to 0.13 mSv).

Humans↗
PubMed1984

Pheochromocytoma of the urinary bladder--a case report and review of the literature.

A pheochromocytoma of the urinary bladder in an 18-year-old male patient with typical clinical symptoms is reported. The blood pressure after micturition was above 300 mm Hg, the vanillylmandelic acid concentration in the 24-hour urinary excretion was elevated 4 or 5 times. Computed tomography and sonography were especially suited for diagnostic localization. The postoperative course has to be supervised, especially as recurrence has been observed.

Adolescent↗
PubMed1984

Some acid-base balance-dependent urinary parameters and calcium-binding anions in stone formers.

Urinary organic acids were determined by gradual titration of portioned urine samples of moderately and severely recurrent stone patients and compared to those found in healthy controls. An essential deficit of organic acids was found in patients with a high recurrence rate. According to the results, the lack of organic acids in the urine of urolithiasis patients, accompanied by a reduced inhibition of the calcium-oxalate and calcium-phosphate crystallization might be causatively involved in the stone formation.

Anions↗
PubMed1983

[Coincidence of peptic lesions in the upper gastrointestinal tract].

In 3935 patients who underwent upper fiberpanendoscopy in two Zurich hospitals the coincidence of different active peptide lesions has been investigated. There was an association of reflux esophagitis and duodenal ulcer in old age: in patients with reflux esophagitis aged over 60 years, duodenal ulcer was found twice as often as in elderly patients without esophagitis. No association of reflux esophagitis and gastric ulcer or of gastric ulcer and duodenal ulcer was observed.

Age Factors↗
PubMed1983

[Dislocated supracondylar femoral fractures, slipped epiphyses and epiphyseal fractures in children].

Dislocated supracondylar femoral fractures are usually transverse fractures and are unstable. In our opinion the primary treatment of these fractures should be surgical in order to save the patient a protracted healing period. Osteosynthesis using a straight plate is impossible, as the distal fragment is too short. Condylar plates are contraindicated and angular plates have too little stability. We feel that intramedullary pins are unsuitable in children. They provide too little stability when the distal fragment is short. Up to now we have achieved the best results with external fixation. Slipped epiphyses and epiphyseal fractures do not present problems as far as the surgical procedure is concerned (removal of the displaced periosteum, repositioning and compression). Healing is not delayed. The long-term results are poor, however, due to premature closure of the damaged epiphyseal plate.

Adolescent↗