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Biomedical subjects

E Vignon

Publications and source records attributed to E Vignon.

At least 109 records · Page 6Linked to original sources
PubMed1990

[Effects of non-steroidal anti-inflammatory drugs on the enzymatic degradation of osteoarthritic cartilage].

The proteoglycannasic and collagenolytic activity the fissured, osteoarthritic human cartilage has been studied in vitro, using proteoglycannases and collagen type II respectively as marked substrates. The effect of various NSAIDs, used at a concentration corresponding to that of the synovial fluid, on these enzymatic activities has been measured in vitro. Naproxen decreases in a significant and dose-dependent way the enzymatic degradation of the cartilage, but only an inhibition of the proteoglycannase can be hoped for in vivo. Not all NSAIDs seem to have inhibitory effects on the enzymatic degradation of the osteoarthritic cartilage.

Aged↗
PubMed1990

Study of the effect of a glycosaminoglycan-peptide complex on the degradative enzyme activities in human osteoarthritic cartilage.

The in vitro collagenolytic and proteoglycanasic activity from human fibrillated osteoarthritic cartilage was determined using labelled proteoglycans and type II collagen as substrates. In vitro, a glycosaminoglycan-peptide complex (GP-C Rumalon) induced a dose-dependent inhibition of both collagenolytic and proteoglycanasic activities while sodium salicylate and indomethacin had only a weak suppressive effect on proteoglycanase. Phospholipase A2 activity was unmodified by GP-C suggesting that the effect of the drug on degradative enzymes was unrelated to prostaglandin formation.

Aged↗
PubMed1990

Cartilage degradative enzymes in human osteoarthritis: effect of a nonsteroidal antiinflammatory drug administered orally.

The activity of stromelysin and collagenase was determined in fibrillated human OA cartilage using labeled proteoglycans and type II collagen as substrates. In vitro paracetamol had no effect on metalloprotease whereas TA induced a significant inhibition of stromelysin. In cartilage and synovium from nine patients treated with TA and nine patients treated with paracetamol during 8 weeks before surgery for hip OA, stromelysin activity was significantly lower in the TA than in the paracetamol group. The results suggest that TA has a potential chondroprotective effect in OA.

Acetaminophen↗
PubMed1990

Glycosyltransferase activities in chondrocytes from osteoarthritic and normal human articular cartilage.

Six glycosyltransferases (mannosyl-, glucosyl-, N-acetyl-glucosaminyl-, galactosyl-, sialyl- and fucosyltransferases) are studied and characterized for their optimal conditions and their relations with interfering reactions (glycosyl-nucleotide pyrophosphatases, glycosidases and proteinases) in chondrocytes from osteoarthritic and normal human articular cartilage. Osteoarthritis induces increased activities for five glycosyl-transferases. The observed modifications are not explained by alterations in physico-chemical parameters of the enzymes or by intervention of glycosyl-nucleotide pyrophosphatases, glycosidases or proteolytic enzymes.

Cartilage, Articular↗
PubMed1990

Histaminergic H1, serotoninergic, beta adrenergic and dopaminergic receptors in human osteoarthritic cartilage.

Using radioligand binding assays, histaminergic H1, serotoninergic, dopaminergic and Beta adrenergic receptors were studied in human normal and osteoarthritic cartilage. The four studied receptors were present in normal cartilage; serotoninergic, dopaminergic and Beta adrenergic receptors were significantly increased in osteoarthritic cartilage while histaminergic H1 receptors were significantly increased only in osteophytic cartilage. The results are consistent with a non specific activation of osteoarthritic chondrocytes.

Cartilage, Articular↗
PubMed1990

[Incidence of vertebral hyperostosis in patients with calcified tendinitis of the shoulder. Prospective study].

A vertebral hyperostosis was reported in 54.3 p. cent of the cases in 46 patients with calcified tendinitis of the shoulder, in 12.5 p. cent of the cases in 32 patients with a simple tendinitis of the shoulder and in 9.6 p. cent of the cases in 62 control patients without any scapular symptoms nor shoulder calcifications. The possible explanations of this significant association between vertebral hyperostosis and calcified tendinitis are considered.

Adult↗
PubMed1989

[Inflammation and cartilage].

The integrity of the collagen network and the proteoglycans is essential for the maintenance of the mechanical properties of cartilage. In spite of a slow turnover, cartilage is able to modify the synthesis of its matrix and has reparative powers. Chondrocytes also possess the enzymes necessary for degrading the matrix. Most substances which are mediators in the inflammatory process act on cartilage, either by inhibiting synthesis, or by stimulating the enzymes involved in degradation. The multiplicity of the mediators (kinin, histamine, serotonin, complement, free oxygen radicals, pharmacologically active lipids, cytokinin) and the interactions among the various systems that are called into play account for the difficulties encountered in treatment.

Arthritis↗
PubMed1989

Effects of tiaprofenic acid on interleukin 1, phospholipase A2 activity, prostaglandins, neutral protease, and collagenase activity in rheumatoid synovial fluid.

IL-1 and prostaglandin (PGE2, PGF2 alpha, TXB2) concentrations, PLA2 activity, neutral protease activity, and collagenase activity specific for types I and II collagen were determined in the SF of patients suffering from RA, before and after treatment with TA. Active and latent forms of protease and collagenases were regularly detected but were unrelated to IL-1, PLA2, and PGE2. TA induced a significant decrease in tested eicosanoids but IL-1, PLA2, and proteases were unchanged.

Adult↗
PubMed1989

[Measurement of the variation in the thickness of lumbar disks over time in patients with lumbago].

The average thickness of the last 3 lumbar disks was measured using an automatic image analyzer in 53 patients who were regularly followed-up both clinically and radiographically for an average period of 14.8 years (extremes: 6 and 39 years). This retrospective study showed that disks do not necessarily become pinched with age, even in patients with lumbago, that the rate of disk pinching is extremely variable from one patient to another, that disk collapse takes an average of 20 to 30 years, that there is a correlation between the severity of the lumbago and the rate at which the disk pinches, and that there are rapidly evolutive discopathies which are responsible for severe lumbago.

Adult↗
PubMed1989

Phospholipase A2 activity in human osteoarthritic cartilage.

Phospholipase A2 (PLA2) activity was measured in articular cartilage from normal and osteoarthritic (OA) human femoral heads. Protoglycanase and collagenase activity was determined in the same specimens using radiolabelled human proteoglycan subunit and type II collagen, respectively. Grossly normal and fibrillated OA cartilage samples showed a significant increase in PLA2 activity which was not found in osteophytic cartilage. PLA2 activity was found to be correlated with proteoglycanase but unrelated to collagenase activity. Tiaprofenic acid induced in vitro a concomitant increase in PLA2 and a decrease in proteoglycanase activity. PLA2 which may be activated by cytokines as well as mechanical factors is suggested as a key enzyme in chondrocyte metabolism regulation. Tiaprofenic acid is shown as a potential chondroprotective nonsteroidal anti-inflammatory drug.

Aged↗
PubMed1988

Antibodies to types I, II, IX, and XI collagen in the serum of patients with rheumatic diseases.

Antibodies to native types I, II, IX, and XI collagen were measured, using a 125I-solid-phase radioimmunoassay, in serum from 104 patients with rheumatic diseases (rheumatoid arthritis, osteoporosis, Paget's disease, or osteoarthritis). In all disease groups, antibodies to type II collagen occurred with greater frequency than antibodies to type I collagen (11-35% versus 5-23%). Antibodies to type XI collagen were the most frequent: They were present in approximately 50% of the patients in the rheumatoid arthritis, Paget's disease, and osteoporosis groups. Antibodies to type IX collagen were found at a high frequency in the rheumatoid arthritis group only (44%). Analysis of the clinical data suggested that the presence of antibodies to collagen was associated with disease that was less severe or of shorter duration.

Adult↗
PubMed1988

Significance of solitary spine abnormalities on technetium-99m bone imaging.

Solitary abnormalities located within the spine from 75 bone images with Tc-99m MDP were reviewed. For the sake of convenience, patients were grouped in three classes of age: 15-50, 51-65, and 66-90 years. In 67 cases, the diagnosis was apparent from clinical studies, x-ray examinations, or biopsies. In eight cases, no diagnosis could be made. The maximum percentage of lesion sites were within the lumbar spine (45 cases). Metastatic lesions were the most common solitary abnormalities within the spine (29.3%). Osteoporosis was second (24%) with the maximum percentage in age group 66-99 years (83%) with a greater female predominance (67%).

Adult↗