Biomedical subjects

E Vignon

Publications and source records attributed to E Vignon.

166 records · Page 10Linked to original sources

PubMedDate not supplied

Macroscopically normal cartilage from the human osteoarthritis femoral head. I. Histological evaluation.

Thirty-five macroscopically "normal" cartilage specimens from 32 osteoarthritic (OA) femoral heads removed surgically were histologically analyzed, and found to be composed of both normal and abnormal cartilage. The latter showed either middle tissue layer alterations or invasion by new tissues of extracartilaginous origin. Middle cartilage layer alterations consisted of unmasked fibers and loss of matrix staining with alcian blue and were found to be closely related to the development of new osteophytic tissues. Thus in OA the appearance to the naked eye of normal cartilage is inappropriate for valid biochemical studies, and a microscopic control of "normal tissue" appears to be necessary for any study of early cartilage changes in OA.

Adult↗

PubMedDate not supplied

Macroscopically normal cartilage from the human osteoarthritic femoral head. II. Measurement of cartilage thickness and cell density.

Cell density and thickness of macroscopically "normal" cartilage from 32 osteoarthritic (OA) femoral heads removed surgically have been studied by using histomorphometry. The results have been interpreted with special reference to qualitative aspects of regions analyzed at a microscopic level. OA cartilage with a microscopically normal appearance have a normal cell content and thickness except for the region adjacent to the zone of cartilage cleavage where a significant reduction in superficial cell density was found. OA cartilage showing middle tissue layer lesions such as unmasked fibers was characterized by an almost normal cellularity but a significantly increased tissue thickness.

Cartilage↗

PubMedDate not supplied

[LP 200mg flurbiprofen versus LP 200mg ketoprofen in rheumatoid arthritis in rheumatologic practice].

A multicentre, randomised, double-blind, double-dummy, parallel-group study in outpatients with rheumatoid arthritis compared the efficacy and safety of flurbiprofen 200 mg and ketoprofen 200 mg, both in sustained-release form. One hundred and sixteen patients aged 18 to 75 years were randomised to receive either one capsule of flurbiprofen sustained-release 200 mg (n = 60) or one tablet of ketoprofen sustained-release 200 mg (n = 56). Both drugs were taken once daily in the evening for 28 days. Patients were assessed at entry and after two and four weeks. Overall efficacy as evaluated on a four-point scale by the investigator and patient, and overall spontaneous pain as evaluated by the patient showed significant improvements in both treatment groups with a trend favouring greater benefit with flurbiprofen. Adverse events were recorded in 14 patients receiving flurbiprofen and 22 patients receiving ketoprofen. Neither the incidence nor the type of adverse events were significantly different in the two groups. Withdrawal rates for adverse events were very similar with both drugs. In conclusion, flurbiprofen sustained-release 200 mg is as effective as ketoprofen sustained-release 200 mg in the treatment of symptoms of rheumatoid arthritis, and exhibits a comparable safety profile.

Adult↗

PubMedDate not supplied

The cell density of human femoral head cartilage.

The human femoral head cartilage in 63 subjects with ages ranging from 16 to 100 years demonstrates that in the course of aging the cell density of the whole cartilage thickness decreases about 40 per cent. The reduction of the cellularity with age is more accentuated in the superficial than in the deeper zone and is even limited to the superficial zone during the latter part of aging. Proportionately the cell loss is similar in the superior and inferior poles of femoral head suggesting a uniform distribution of age related changes. In absolute value, the decrease of the superficial cell density is much higher in the inferior than in the superior pole; the decrease may be related to the propensity of this region to fibrillation.

Adolescent↗