Biomedical subjects

E Victor Ross

Publications and source records attributed to E Victor Ross.

22 records · Page 2Linked to original sources

PubMed2002

Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase I.

BACKGROUND: Presented here is phase I of a three-part study of non-ablative cutaneous remodeling with a 1.45 microm diode laser configured with a cryogen spray cooling device. METHODS: Eight men and two women (average age of 67 years) with Fitzpatrick skin phototypes I-IV were treated at postauricular sites. Treatment consisted of one or two passes with a 4mm spot and an average power of 12 W. Heating times ranged from 150 ms to 500 ms applied over two to six treatment cycles. One treatment 'cycle' lasted for 100 ms and consisted of programmable parallel cryogen spray cooling pulses interspersed with unopposed heating. Biopsies were obtained at baseline, immediately after treatment, and at 2 months. RESULTS: Patients were assessed 1 day, 1 week, 1 month and 2 months after treatment. Treatments were well tolerated with minimal pain, with a trend towards increasing discomfort with longer heating times. Erythema and edema were also mild and short-lived. There was a direct relationship between the degree of erythema and edema, and longer unopposed heating times. Mild hyperpigmentation occurred at only three treatment sites. Epidermal burns usually presented as immediate whitening in 11 of 60 one-pass sites and four of 16 two-pass sites. Whitening was associated with longer unopposed heating times. Atrophic, pitted scars occurred at two single-pass sites and three double-pass sites. Baseline biopsies demonstrated solar elastosis in a 375 microm thick band (mean range from 100 microm to 480 microm deep in the dermis). Immediate post-treatment biopsies demonstrated thermal damage in a 333 microm thick band (mean range from 311 microm to 644 microm deep in the dermis). Finally, dermal fibrosis was observed 2 months after treatment in a 272 microm thick band (mean range from 148 microm to 420 microm deep in the dermis). CONCLUSION: The 1.45 microm diode laser is capable of targeting dermal collagen and stimulating fibrosis at depths where solar elastosis resides. Longer unopposed heating times corresponded to increased erythema, edema, and pain, which were typically mild and short-lived. Epidermal burns can result in pitted scars.

Adult↗

PubMed2002

Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase II.

BACKGROUND: Presented here is phase II of a three-part study of non-ablative cutaneous remodeling with a 1.45 microm diode laser configured with cryogen spray cooling. In phase I, safe heating and cooling parameters were established by examining gross and microscopic changes induced by the laser. Phase II examines clinical changes and side effects in the treatment of single facial rhytids. METHODS: Two men and seven women with Fitzpatrick skin phototypes I-III were treated. Single facial rhytids were treated on three separate occasions 3 weeks apart (six periorbital and three perioral). Single, control wrinkles on the contralateral sides were treated with cryogen spray cooling alone. Subjects were treated with single passes with a 5mm spot for the first two treatments. Owing to a modification in the handpiece design, a 4mm spot was used for the third and final treatment. The average power was 12 W. At each treatment visit, heating times ranged from 200 ms to 300 ms, applied as a series of heating/cooling cycles. One treatment 'cycle' lasted for 100 ms and consisted of continuous laser heating interspersed with programmable parallel cryogen spray cooling bursts. RESULTS: Patients were assessed 1 day, 1 week, 4 months, and 6 months after treatment. Treatments were well tolerated, and no patient required pain control pre or post operatively. Mild erythema and edema were noted immediately after treatment and typically cleared within 2-3 days. Superficial, branny hyperpigmentation occurred in six patients at both treatment and control sides. This discoloration resolved within 1 week of treatment and left no residual pigment alterations. No whitening or residual scarring occurred. Rhytid scores improved from a baseline score of 2.3 to 1.8 at 6 months after treatment (p>0.05). Patient acceptance of the treatment was high, but most felt that there was little improvement of the treated rhytids. CONCLUSION: Although the 1.45 microm diode laser is capable of targeting dermal collagen and stimulating fibrosis at depths where solar elastosis resides, clinical improvement of rhytids was mild and did not correlate well with the degree of histologic changes noted in phase I.

Adult↗

PubMed2002

Treatment of pseudofolliculitis barbae in very dark skin with a long pulse Nd:YAG laser.

BACKGROUND: Pseudofolliculitis barbae affects some individuals with coarse curly hair. Currently available treatment modalities are often ineffective. In some studies, lasers have been shown to be potentially helpful in mitigating disease severity by reducing the number and/or thickness of hair shafts. METHODS: This was a side-by-side interventional study conducted at a military tertiary medical facility. The study group included 26 patients (skin types IV, V, and VI) referred from primary care physicians with a diagnosis of pseudofolliculitis barbae refractory to medical therapy. A neodymium YAG laser was used to treat one half of the neck. One month later, shaving bumps were counted and compared to their preoperative levels on both sides. RESULTS: Mean postoperative papule counts were 11.6 +/- 6 (SD) and 30.1 +/- 19 (SD) on the treated side and untreated sides, respectively. CONCLUSION: Neodymium YAG laser treatment represents a safe and effective option for reducing papule formation in patients with pseudofolliculitis barbae.

Black or African American↗

PubMedDate not supplied

Optical treatments for acne.

Light-based treatments for acne are becoming increasingly commonplace in dermatology. This article reviews various light approaches in acne therapy. Methods are discussed from an anatomical and a functional perspective. The emphasis is on the practicality of treatment as well as the pros and cons of various devices. Also, a review of the recent literature is presented. The article is intended to give the reader a panoramic view of this still-young and developing area. Most likely, light-based acne treatment will receive more popularity as dermatologists learn how to integrate this type of therapy within the context of more established drug agents.

Acne Vulgaris↗