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Biomedical subjects

E Vatashsky

Publications and source records attributed to E Vatashsky.

7 recordsLinked to original sources
PubMed1986

Mechanism of antagonism by physostigmine of acute flunitrazepam intoxication.

The effect of physostigmine on the loss of consciousness and respiratory depression induced in rabbits by flunitrazepam, 1 mg/kg, was studied to demonstrate whether the restoration of consciousness and respiration rate results from an increase in central cholinergic activity or from an interference by physostigmine with specific binding of flunitrazepam to its receptors. Physostigmine, 0.1-0.4 mg/kg iv, caused a dose-related reversal of consciousness and respiration rate within 15 min of its injection, which lasted 15-30 min depending on the dose. This was associated with peak inhibition of acetylcholinesterase (AChE) in the frontal cortex and medulla, at 15 min, ranging from 35-51%. The analeptic effect of physostigmine in flunitrazepam-treated rabbits was prevented by pretreatment with scopolamine, 1 mg/kg. The effective dose range for physostigmine, 3-12 mumol/kg, is close to concentrations of this agent that inhibit activity in solubilized preparations of AChE from rabbit cortex, 1-3 X 10(-8) M. However, physostigmine, 10(-9) -10(-4) M, failed to displace 3H flunitrazepam from specific binding sites on membranes prepared from rabbit cerebral cortex. It is concluded that physostigmine antagonizes the somnolence and respiratory depression induced by benzodiazepines by restoring cholinergic transmission to normal levels. The effective dose range of physostigmine is small, and serious side effects from overdose can occur as a result of excess cholinergic activity at neuromuscular synapses.

Acetylcholinesterase↗
PubMed1986

"Conscious sedation" for laparoscopy.

End-tidal pCO2, mean arterial blood pressure, heart rate and respiratory rate changes during diagnostic gynecological laparoscopy were studied in 30 healthy women by the technique of "conscious sedation" combined with local anesthesia of the skin and peritoneum. No significant hypercarbia or hypoxia was noted. Patients were discharged from hospital within 6 to 8 h of the laparoscopy; all noted their full satisfaction with this method of anesthesia. "Conscious sedation" appears to be a safe and efficient method for short diagnosis laparoscopies in young, nonobese, otherwise healthy patients in whom full general anesthesia is refused or considered inadvisable.

Adult↗