Biomedical subjects
Publications and source records attributed to E V Mironova.
Nebivolol was given to 59 patients with hypertension for 8 weeks. This was accompanied by augmentation of amplitude of photoplethysmogram in all and normalization of blood pressure in 67% of patients. Nebivolol did not cause orthostatic hypotension or bronchial spasm.
A method for synthesis of retinal analogs labeled with electron-density groups is suggested. The interaction of these polyene compounds with bacterioopsin in apomembrane of Halobacterium salinarum was tested. A retinal analog containing a crown-ether receptor group is able to interact readily with bacterioopsin giving rise to rapid formation of a pigment with absorption maximum at 460 nm. This pigment is capable of undergoing cyclic photoconversion. The crown-bacteriorhodopsin photocycle is extremely slow and its quantum efficiency is very low (approximately 3% of that in native bacteriorhodopsin). This photocycle includes an M-like intermediate with a differential absorption maximum at 380 nm. A retinal analog in which the beta-ionone ring is replaced by ferrocene moiety forms a stable chromoprotein with the main absorption band at 483 nm and a shoulder near 590-610 nm.
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A study is presented of 89 workers contacting with benzene and its derivatives and 98 workers without contacts with chemical substances. Radioimmunological assay of peripheral blood B2-microglobulin was carried out. Persons with a length of work over 10 years contacting with anilin and its derivatives showed a marked increase of B2-microglobulin in the blood serum as well a marked reduction of leucocyte number. It is considered that leucopenia with granulocytopenia and marked increase of B2-microglobulin is regarded as a preleucosis state.
Stresses such as the anxiety neurosis, are the cause of the magnesium metabolism disorders in the heart, brain, liver, and induce an increase in the fatty acids/magnesium ratio in the blood at the expense of such NEFA as C16:0, C18:1, C20:4.
A method of simultaneous one-stage synthesis of three retinal derivatives (5,6-dioxo-5,6-seco-, 5,6-dihydro-5,6-epoxy-, and 4-oxoretinal) was proposed, with the yield of the first derivative being approximately 50%. These compounds are useful tools for studying the antitumor activity of retinoids, the reconstituted bacteriorhodopsin analogues with changed parameters of photocycle, and the reactivity of retinal derivatives in the processes of oxidation by molecular oxygen. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru.
Eighty-five patients with acquired heart diseases with and without infective endocarditis (IE) were examined. In one group of patients traditional therapy was supplemented by the Russian drug immunofan, a synthetic hexapeptide with immunomodulating, antiinflammatory, and detoxifying effects. A course consisted of 10 intramuscular injections every other day (1 ml of 0.005% solution). The drug was prescribed after immunological studies on a laser flow cytometer (Becton Dickinson, USA). Correction was carried out before and after the operation. The postoperative period was uneventful in patients treated with immunofan; the incidence of clinical manifestations of IE was decreased. The concentrations of cytokines (IL-1, IL-6, TNF-alpha) in the blood were increased in patients with IE. In patients treated with immunofan, the concentrations of cytokines were decreased and immune parameters were normalized. Changes in the cytokine status can be used as a laboratory test for evaluating the efficiency of treatment in cardiosurgical patients with IE.
Our investigations evidence that intravascular laser radiation of the blood is an effective method of treatment of chronic lympholeucosis. The average hospitalization time became shorter, the period of clinical remission increased. N positive dynamics in the content of beta 2-microglobulin was noted, peripheral blood values improved, the dysbalance of cellular and humoral immunity was controlled.
Stress itself as well as the subsequent myocardium necrosis developed after stress were mainly responsible for distinct decrease in concentration of somatotropin, somatomedin and for impairments in protein synthesis accompanied by decrease in proteins half-life in brain hemispheres and in non-ischemized heart left ventricle.
An emotional-algesic stress in the period of its development and after-effect causes a different-directed influence on the state of the ionic transport in the heart and brain of rats. The Na+, K+-ATPase activity in the left ventricle of the heart decreases with a simultaneous increase in the sodium content and decrease in the calcium and potassium content. The Na+, K+-ATPase activation is observed in the cortex of cerebral hemispheres with a simultaneous increase in the content of mentioned ions.
Calcium balance was impaired in a body during myocardium necrosis. Emotional stress, which preceded the myocardial necrosis, fortified these impairments. This was manifested as follows: an increased rate of calcium excretion and elevated hypocalcemia, accumulation of calcium in liver tissue, aorta, brain hemispheres and a decrease of its content in the intact tissue of left heart ventricle.
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Emotional stress caused distinct alterations in calcium metabolism and hypocalcemia development was observed. At the same time, negative balance of calcium, redistribution of calcium in tissues as well as alteration of the 3; 5'-AMP content in the tissues were noted.
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