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Biomedical subjects

E V Lally

Publications and source records attributed to E V Lally.

33 records · Page 2Linked to original sources
PubMed1987

Gold lung: recent developments in pathogenesis, diagnosis, and therapy.

Gold lung is a hypersensitivity pneumonitis to gold-containing compounds. It can be distinguished from rheumatoid lung by its subacute or acute onset, diffuse interstitial and/or alveolar filling pattern on chest roentgenogram, presence of lymphocytes on BAL with an inverse helper/suppressor ratio, and response to withdrawal of gold and/or corticosteroid therapy. Other in vitro assays of gold hypersensitivity using peripheral blood lymphocytes are only sporadically positive and, therefore, of limited value in making the diagnosis. Physicians prescribing organic gold compounds should elicit pulmonary complaints throughout the duration of therapy. When patients receiving gold therapy present with signs and symptoms consistent with an acute or subacute hypersensitivity pneumonitis, the gold therapy should be withheld and a diagnostic workup initiated.

Aged↗
PubMed1987

Reflex sympathetic dystrophy following nail biopsy.

Reflex sympathetic dystrophy following a nail unit biopsy in a patient with long-standing, mycologically negative onychomycosis is reported. The significance of this complication is discussed, and the literature on the condition itself is reviewed. It is suggested that although adverse effects occur as a result of nail biopsy, they are infrequent and therefore should not dissuade the clinician from performing the procedure. Biopsy is necessary in order to establish a more accurate diagnosis of nail disease and thus administer more appropriate and effective therapy.

Adult↗
PubMed1986

Ossification of the plantar fascia and peroneus longus tendons in diffuse idiopathic skeletal hyperostosis (DISH).

Extraspinal skeletal changes in diffuse idiopathic skeletal hyperostosis (DISH) consist of bony proliferation at ligamentous and tendinous insertions. We describe a patient with DISH who manifested ossific changes in the plantar fascia and peroneus longus tendon bilaterally at sites not immediately adjacent to the bony insertions of these structures. This observation expands the roentgenographic spectrum of DISH.

Foot Diseases↗
PubMed1986

The clinical spectrum of gouty arthritis in women.

We reviewed crystal-proved gouty arthritis in 23 women. Twenty-one (91%) developed gout after menopause onset. Tophaceous gout occurred in six (26%), polyarticular involvement in 13 (57%); 70% manifested an underlying arthropathy, usually osteoarthritis. We studied 75 men with crystal-proved gout for comparison. Women developed gout significantly later compared with men, more often were receiving diuretics before gout onset, and more frequently manifested renal insufficiency and monoarticular involvement. These differences were significant when controlled for the women's later age at onset. Significantly more men than women had alcoholism and an identifiable precipitating event for acute attacks. There were no significant differences in race, age, family history of gout, disease duration, hypertension, distribution of joint involvement, tophi, or mean serum urate concentration. Gout in women is overwhelmingly postmenopausal, apparently associated with diuretic therapy and renal insufficiency independent of the effects of age. Articular characteristics in men and women are remarkably similar.

Adult↗
PubMed1985

Two-dimensional echocardiographic detection of preclinical aortic root abnormalities in rheumatoid variant diseases.

Two-dimensional echocardiographic findings of subaortic fibrous ridging, aortic leaflet thickening, and aortic root dilatation and thickening are described in a group of 36 patients with rheumatoid variant diseases. The group consisted of 25 patients with ankylosing spondylitis, nine patients with Reiter's syndrome, and two patients with inflammatory bowel disease and spondylitis. No patient had clinical or laboratory evidence of aortic regurgitation or heart block. Subaortic fibrous ridging or marked leaflet thickening was noted in 11 of 36 patients; in contrast, no such changes were found in an age-matched control group of 29 men. The subgroup of patients with subaortic fibrous ridging or leaflet thickening (11 patients) had significantly longer disease duration (28.1 versus 17.7 years) and higher incidence of aortic root echo-density (82 versus 36 percent) than the remaining patients. It is concluded that a significant portion of patients with ankylosing spondylitis or Reiter's syndrome have echocardiographic evidence of aortic root involvement prior to the clinical onset of aortic regurgitation.

Adult↗
PubMed1985

The clinical significance of periodic acid-Schiff-positive deposits in cuticle-proximal nail fold biopsy specimens.

In vivo capillary microscopic findings and proximal nail fold biopsy specimens from 19 patients with various connective tissue diseases, idiopathic Raynaud's phenomenon, and non-connective tissue diseases were studied. Periodic acid-Schiff-positive serous cuticular deposits were not specific to the group of patients with connective tissue disease. Generally, the severity of deposits correlated with the severity of the in vivo capillary microscopic pattern but not with disease severity or duration. The finding of these cuticular deposits may help to identify those patients with idiopathic Raynaud's phenomenon who are at risk to develop a connective tissue disease.

Adult↗
PubMed1985

Pathologic involvement of the urinary bladder in progressive systemic sclerosis.

We describe 2 patients with progressive systemic sclerosis (PSS) who manifested characteristic pathologic abnormalities in the urinary bladder. Increased connective tissue deposition in the lamina propria and between smooth muscle bundles was demonstrated in both patients and endovascular proliferation in small arteries of the bladder was noted in one patient. Both patients had persistent unexplained microscopic hematuria; one patient manifested urinary frequency and incontinence. The relationship of these clinical abnormalities to the pathologic findings in the bladder is unclear. Structural or functional abnormalities of the urinary bladder may develop in patients with PSS.

Adult↗
PubMed1983

Diaphyseal bone infarctions in a patient with sickle cell trait.

Bone and joint abnormalities occur frequently in sickle cell anemia but are rare in sickle cell trait. Long bone diaphyseal infarctions are distinctly unusual in sickle cell trait. We describe a patient with AS hemoglobin and symptomatic bone infarctions in the diaphyses and metadiaphyses of the long bones of the lower extremities and in the calcaneus. In addition, this patient manifested noninflammatory synovial effusions of the knee. The bone and joint manifestations of sickle cell trait are reviewed in the context of this case.

Adult↗
PubMed1981

Impotence in progressively systemic sclerosis.

Five men with progressive systemic sclerosis presented with impotence as a significant initial feature of their disease. Endocrine, urologic, and psychiatric evaluations failed to reveal another cause for impotence. We suggest that male erectile dysfunction represents another manifestation of systemic sclerosis. Possible mechanisms for this phenomenon are discussed.

Adult↗
PubMedDate not supplied

Acute gouty arthritis and systemic lupus erythematosus.

A young black woman with systemic lupus erythematosus (SLE) who developed acute gouty arthritis of her great toe is described. The association of these 2 rheumatic diseases has been rarely reported. Factors that may be responsible for the unusual coexistence of SLE and gout are discussed. Crystal-associated arthritis should be considered in the differential diagnosis of acute oligoarthritis in SLE.

Acute Disease↗