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Biomedical subjects

E Usai

Publications and source records attributed to E Usai.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Ureteral lithotripsy with rigid ureteroscopy and pulsed dye laser].

Pulsed dye laser lithotripsy represents nowadays a new approach to ureteral stones. 27 patients were treated with a pulsed dye laser unit (Pulsolith TM) at our department from november 1989 to january 1990. 21 had a single stone and the remaining a multiple ureteral lithiasis. The pulsed dye laser operated at a wave length of 504 nm, energy ranged between 90 and 160 mj with pulse of 1,5 ms. A 320 theta diameter quartz fiber with Helium Neon red laser (to visualize the top of the fiber) introduced in a rigid 9.5 ureteroscope (Wolf) was used during the procedure. Spinal, peridural or general anesthesia was done in all patients and the time of the procedure ranged between 8-150 minutes. Fiber was inserted in a 4 Ch ureteral catheter which provided easier manipulation of the fiber. Complete fragmentation was achieved in 88.9% of the patients, and combined manoeuvres were requested in another 3.7%. Failures were 7.4%. Minimal lesions of the ureter, due to ureteroscope advancement subsided spontaneously after placement of double F catheter. Pulsed dye laser lithotripsy seems to be a safe and useful procedure for treatment of impacted ureteral calculi and seems to offer low morbidity in respect of ultrasonic or electrohydraulic procedures especially when the stone location does not permit an ESWL approach.

Coloring Agents↗
PubMed1991

[Simple renal cysts, biochemical analysis of the cystic fluid, and comparison with blood parameters].

62 specimens of cystic fluid drawn back by ultrasound guided needle-aspiration in 37 males and 25 females were evaluated biochemical analysis including magnesium, calcium, phosphorus, chloride, uric acid, total protein, sugar, urea, creatinine, sodium, potassium, total cholesterol, AST, ALT, ALP, ACP, PAP, alpha-amilasys. In our study Cl, Na and sugar showed similar concentrations in the two fluids. Uric acid, and urea were more concentrated in the cystic fluid while Mg, Ca and total protein were more pronounced in the blood. The results obtained seem to indicate that simple renal cyst could originate from glomerular proximal tubulus part of the nephron as consequence of an obstructive cause.

Female↗
PubMed1991

[Clinical observations about an oligomineral water from the "Funtana Piscamu" of San Leonardo di Siete Fuentes].

In this study we evaluated the effects induced by the administration of a natural oligomineral water "Funtana Piscamo" di San Leonardo di Siete Fuentes on patient with urinary stone disease. Urine from 30 stone formers attending our metabolic stone clinic were compared with freshly voided urine of 20 normal volunteers. A marked increase in urinary magnesium (p less than 0.001) and a change in the urinary Ca/Mg ratio (p less than 0.005) were the most striking features disclosed in patients with stone disease. This natural oligomineral water drawn from "Funtana Piscamu di San Leonardo di Siete Fuentes" seems to have a long-term efficacy in urinary stone prevention.

Adult↗
PubMed1991

[Intravesical chemoprophylaxis with beta-interferon in superficial carcinoma of the bladder].

24 patients with recurrent (group 1) or primary (group 2) bladder cancer (ta/t1 G2) were given 50.000.000 U.I. of beta interferon intravesically after TUR of the neoplasm. In group 1 recurrence rate (rr) was 100% in the period before INF and 83% after INF treatment (follow-up 15-24 months, median 19.8) (p = ns). In group 2 rr was 25% in a 24 months, median 19.8) (p = ns). In group 2 rr was 25% in a 24 months follow-up period; if compared to the rr of a historical control group treated by only a TUR (38.2%) there was a statistically significant difference (p less than 0.01). Tolerability of the drug was excellent.

Administration, Intravesical↗
PubMed1991

Serum and urine ferritin in patients with transitional cell carcinoma of the bladder.

Erythrocyte, serum and urine ferritin concentrations were evaluated in 20 patients suffering from transitional cell carcinoma of the urinary bladder and in 20 healthy men. No clinical or biochemical signs of liver disorders, chronic inflammatory states or infections were present in both the patients and the controls. Our results showed no significant difference in the erythrocyte ferritin concentration in both groups. On the contrary there was a statistically significant difference in mean serum (p less than 0.05) and urine (p less than 0.01) ferritin concentration between the two groups. The mean serum ferritin concentration in the patients was 102.23 +/- 63.38 ng/ml while it was 258.41 + 250.68 ng/ml in normal subjects. The mean urine ferritin concentration was 6.30 +/- 5.35 ng/ml in normal subjects and 22.66 +/- 25.59 ng/ml in patients with bladder cancer. Our data seem to demonstrate that the assessment of the ferritin either in the serum or preferably, in the urine, could become an interesting tumoral marker for bladder cancer.

Carcinoma, Transitional Cell↗
PubMed1991

Evaluation of efficacy and tolerability of Nilutamide and Buserelin in the treatment of advanced prostate cancer.

Several different medical strategies have been proposed for the treatment of advanced prostatic cancer: androgen withdrawal by surgical castration on indirect suppression of androgen production by estrogen or estrogen-like substances, antiandrogen compounds or LH-RH analogues. The Authors evaluated in detail tolerability and efficacy of a combination therapy of a LHRH analogue (Buserelin) and a pure antiandrogen (Nilutamide) in a group of 15 patients with advanced prostate cancer (stage D) followed over a period of six months.

Aged↗
PubMed1991

[Monitoring of erection function in patients with prostatic carcinoma treated with Casodex].

This study evaluates the sleep-related erections in 5 patients with locally advanced prostate cancer (T3NOMO) during 6 months treatment with Casodex by multinight continuous monitoring of penile tumescence and rigidity. Mean serum LH, Testosterone and Estradiol levels shown a no statistically significant increase at the six months control. We found no significant modifications in the number of NPT episodes, maximum penile circumference and rigidity time before and after therapy. Penile arterial flow and neurologic examination were also unmodified. All patients had a stable disease and unchanged performance status after 6 months. This pure antiandrogen in a men with prostate cancer does not seem to interfere with self reported libido and erectile capability.

Androgen Antagonists↗
PubMed1990

Ultrastructure of human bulbourethral glands and of their main excretory ducts.

The endpieces of human bulbourethral (BU) glands, studied with SEM after removal of the connective tissue, consist of short, coiled tubules often dilated into alveoli. Immunohistochemical studies at the EM level have shown that the mucous cells of these glands have mucous droplets, which react to blood group antigens, suggesting that BU glands participate in the secretion of these antigens into the seminal plasma. The main excretory duct is lined by a stratified columnar epithelium consisting of six-seven cellular layers. Cells of superficial layers, that are endowed with typical secretory granules, seem to contribute some unknown components to the secretions of these glands.

ABO Blood-Group System↗
PubMed1990

[Qualitative analysis of 1447 patients with urinary calculi in the period 1979-1989 in Sardinia].

In this work we have examined the results obtained from the chemical analysis of 1447 urinary stones. The data concerning the frequency are distinguished according to the sex. Then we examined the difference between frequency of pure and mixed calculi in a sample, analyzing the results obtained by a subdivision in two periods of five years each. Our data are compared with those obtained in other regions of our country.

Female↗
PubMed1988

The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens in patients with advanced prostate cancer.

The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens was investigated in 6 patients with untreated advanced prostate cancer, aged 52-75 yr. Flutamide was administered (250 mg three times daily) for 10 days; before and after treatment, a synthetic ACTH1-24 stimulation test (250 micrograms im, with blood sampling immediately before and 60 min after the stimulus) was performed. Basal plasma 17OH-pregnenolone (delta 5-17OHP), 170H-progesterone (delta 4-17OHP), androstenedione (A), dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) were unchanged by flutamide treatment. In contrast, basal plasma testosterone (T) concentrations significantly increased (p less than 0.05). The response of cortisol delta 4-17OHP, delta 5-17OHP, A and DHEA to ACTH, as well as the ACTH-stimulated delta 5-17OHP/delta 4-17OHP, delta 5-17OHP/DHEA, delta 4-17OHP/A and DHEA/A ratios, were unchanged by flutamide treatment. These findings indicate that: a) Short-term flutamide administration enhances testicular steroidogenesis, via augmented LH pulse frequency; b) Adrenal steroidogenesis seems to be not affected by the drug, since ACTH-stimulated plasma levels of adrenal androgens and precursors/products ratios were unchanged.

Adrenal Glands↗
PubMed1988

Cytogenetic investigation on 30 bladder carcinomas.

Cytogenetic study of 30 bladder carcinomas confirmed the heterogeneity and the complexity of the karyotypic picture in this type of tumor. Presence of numerical and/or structural chromosome aberrations was observed in all tumors. Clonal abnormalities were found in 19 cases. Chromosomes most frequently involved in changes were chromosome #1, #3 and #11(36.6%, 26.6%, and 20% of the cases respectively). Trisomy 7 and monosomy 9 were the sole abnormalities in one case each.

Chromosome Aberrations↗
PubMed1988

Short term effects of flutamide administration on hypothalamic-pituitary-testicular axis in man.

The effect of short term administration of flutamide on the hypothalamic-pituitary-gonadal axis was studied in six patients with advanced prostate cancer (C2 stage). Flutamide significantly increased LH pulse frequency in all patients (p less than 0.05 by Wilcoxon's test). The FSH pulse analysis disclosed a similar pattern of LH. Plasma IC-T clearly increased following flutamide therapy; mean IC-T values were 2.67 +/- 0.47 ng./ml. and 4.67 +/- 0.62 ng./ml. before and after flutamide administration, respectively (p less than 0.05 by paired Student's t test). Our study demonstrates that flutamide acts in humans as a selective and specific antiandrogen compound.

Aged↗
PubMed1988

Transitional cell carcinoma of the bladder in a young man. A multidisciplinary approach.

A multidisciplinary diagnostic approach to a case of bladder carcinoma in a 19-year-old male smoker is presented. The transitional cell carcinoma was submitted to conventional histological examination, flow cytometry and cytogenetic analysis. Serum and urine tumour markers were also investigated. The tumour was diploid, with an increased proliferative phase, and a chromosome marker was found. A net decrease in serum and urine ferritin concentrations was noted after transurethral resection of the neoplasm and its low malignancy was confirmed at follow-up.

Adult↗
PubMed1988

Histochemistry of L-leucyl beta-naphtylamidase activity in genital tract of men.

The histochemical method to demonstrate L-leucyl-beta-naphtylamidase (LNAase) activity has been applied to biopsies of normal human ductus deferens, deferential ampulla, seminal vesicle, prostate, bulbourethral (Cowper's) gland, and cavernous urethra. An intensely positive reaction was observed in the secreting epithelia of prostate, Cowper's, and urethral (Littré's) glands. Not only the prostate but also the Cowper's and Littré's glands secrete some LNAase into the semen. A possible role of the seminal LNAase is discussed.

Adult↗