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Biomedical subjects

E Ungureanu

Publications and source records attributed to E Ungureanu.

32 records · Page 2Linked to original sources
PubMedDate not supplied

Circannual rhythms of systolic and diastolic blood pressure in relation to plasma aldosterone and urinary norepinephrine in elderly subjects and in children.

Sixty six elderly men and 87 elderly women 77 +/- 8 (S.D.) years of age were studied in 285 profiles consisting of measurements of systolic and diastolic blood pressure obtained at 4 hour intervals during the waking hours of the subjects for 2 or 7 days and (among others) plasma aldosterone and urinary norepinephrine determinations collected in six samples at 4 hour intervals during one 24-hour span. The profiles were spread through all four seasons. The circadian means were calculated for each profile by the single cosinor method and the circannual variations were analyzed by the Bingham test and analysis of variance. A circannual rhythm of the systolic and the diastolic blood pressure was found with a peak systolic pressure in spring and peak diastolic pressure in summer. A circannual rhythm in urinary norepinephrine was statistically significant only in the women with a peak in winter, out of phase with the circannual rhythm in blood pressure. In plasma aldosterone, the highest values were found during fall and winter with statistical significance reached at the p less than .05 level in the women only. In contrast to the elderly subjects, 87 boys and 107 girls 11 +/- 1.5 (S.D.) years of age studied by the same methodology over one 24-hour span each spread throughout the four seasons showed a circannual rhythm in systolic and diastolic blood pressure and in norepinephrine excretion with a peak during winter. A circannual rhythm of the circadian mesor of the plasma aldosterone concentration was found in the children with highest values in fall and lowest values in spring (when the blood pressure values also were lowest). With all qualifications in mind about possible causal relations between rhythms showing a coincidence or a difference in phase, it appears that there are certain differences in the circannual time structure of cardiovascular and related endocrine functions between children and elderly subjects which may be of clinical importance.

Aged↗
PubMedDate not supplied

Circadian rhythm in plasma immunoreactive somatomedin-C in children.

Fifteen boys and 27 girls, 11 +/- 2 years of age were studied over a single 24-hour span during the month of June. Statistically significant circadian rhythms of plasma immunoreactive somatomedin-C (SM-C) concentration, immunoreactive growth hormone (hGH) and cortisol concentration were found, which show marked differences in timing. The highest values of somatomedin-C occurred in the early evening hours (acrophase 19:08) in contrast to growth hormone which showed its peak values during the night and cortisol, which peaked in the morning hours. These observations are of interest for the physiologic regulation of somatomedin-C as well as for the clinical evaluation of plasma immunoreactive somatomedin-C concentrations, and for studies of the response of somatomedin-C to hormonal and/or pharmacologic manipulation.

Adolescent↗
PubMedDate not supplied

Differences in the circadian rhythm parameters of urinary free epinephrine, norepinephrine and dopamine between children and elderly subjects.

The circadian rhythm in the urinary excretion of free epinephrine, norepinephrine and dopamine was studied in 60 elderly men and 83 women, 77 +/- 8 years of age, in a total of 260 24-hour profiles and in 63 boys and 81 girls, 11 +/- 1.5 years of age, in 144 24-hour profiles. The circadian mesor of all these compounds was increased in the children over that in the elderly subjects while the acrophase remained unchanged in spite of a phase shift of the acrophase of the urine excretion of the elderly in the night hours. The differences in functional state of the sympathetic and adreno-medullary function (and/or response) between children and elderly subjects may have clinical implications.

Aged↗