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Biomedical subjects

E Tsou

Publications and source records attributed to E Tsou.

27 records · Page 2Linked to original sources

Radiographic signs of pulmonary embolism.

Contrary to popular belief, the chest x-ray is abnormal in most patients with documented pulmonary emboli. Radiographic signs include elevation of the diaphragm, infiltrate without infarction, pulmonary infarction, atelectasis, pleural effusion, pulmonary edema, signs of reduced blood flow and changes in the pulmonary vasculature. Recognition of these nonspecific signs can alert the physician to the need for definitive testing by lung scanning and angiography.

Aged↗

Parathyroid adenoma with coexistent sarcoid granulomas. A hypercalcemic patient.

A 56-year-old woman had hypercalcemia. Clinical symptoms and chest roentgenograms were suggestive of sarcoidosis. Results of laboratory studies, however, were compatible with primary hyperparathyroidism. At surgical exploration of the neck, a parathyroid adenoma was found. Microscopically, sarcoid-like granulomas were present within the adenoma. The association between hypercalcemic sarcoidosis and primary hyperparathyroidism is reviewed, and the importance of this finding is discussed.

Adenoma↗

Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial.

Eighteen patients with advanced metastatic malignancy who had 21 pleural effusions requiring sclerosis for control were randomly allocated to intrapleural therapy with tetracycline or quinacrine. Tetracycline produced partial or complete control of the effusion in ten of 12 trials for a median duration of 6 months (range 1.5 to 22 months). Partial or complete control was obtained in nine of ten trials with quinacrine, for a median duration of 3 months (range 1 to 13 months). All complete responders who died achieved control of their effusions until their terminal admissions despite clinical evidence of overt systemic tumor progression in the intervening period. Single-dose tetracycline therapy was accompanied by less fever (p less than 0.04) and less pleuritic pain (p = 0.09) than quinacrine. Tetracycline is effective, well tolerated, easily administered, and should be considered as the initial therapy for malignant pleural effusions requiring pleural sclerosis.

Clinical Trials as Topic↗

Pulmonary embolism: dilemmas in diagnosis and therapy.

Pulmonary embolism is unique among cardiorespiratory diseases because of its high frequency of both overdiagnosis and underdiagnosis. The lack of specific and consistent clinical, laboratory, roentgen, and electrocardiographic features lead to this paradox. While the lung scan may be diagnostic in selected cases, the pulmonary angiogram is the most accurate method of demonstrating emoboli short of operative or pathological examination.

Adult↗

Cutaneous infection due to mycobacterium szulgai.

A patient on long term corticosteroid therapy for sarcoidosis developed a cutaneous infection due to Mycobacterium szulgai. No evidence of visceral infection with the organism was found during life or at autopsy. The spread of the infection to multiple skin sites probably occurred by autoinoculation.

Adult↗

Sickle cell lung disease.

When a patient with sickle cell disease has fever and a lung infiltrate, usually it will be due to infection, even though cultures may be negative. However, pulmonary infarction can be virtually indistinguishable from pneumonia. Pneumonia is likely to be present in those younger than five years, with purulent sputum and upper lobe infiltrates. Coexisting crisis, a normal or low leukocyte alkaline phosphatase score and microangiopathic changes on peripheral blood smear favor thromboembolic disease. The fat embolism syndrome, caused by bone marrow necrosis and infarction, occurs in sickle cell disease.

Anemia, Sickle Cell↗