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Biomedical subjects

E Thomas

Publications and source records attributed to E Thomas.

At least 325 records · Page 18Linked to original sources
PubMed1987

Efficacy of sucralfate in the prevention of recurrence of duodenal ulcers.

Eighty-four patients who were endoscopically confirmed to have healed duodenal ulcers were entered into this 1-year, double-blind, placebo-controlled trial of sucralfate, 1g twice daily, in the prevention of duodenal ulcer recurrence. Patients remained in the study until recurrence of ulceration was endoscopically confirmed. Sixty-one patients could be evaluated for efficacy of treatment. Within 6 months, 23 of 31 placebo patients (74%) and 6 of 30 sucralfate patients (20%) had ulcer recurrence. At 12 months, 25 of 31 placebo patients (80%) and 8 of 30 receiving sucralfate (27%) had ulcer recurrence. The lower rate of ulcer recurrence in patients receiving sucralfate was significant (p = 0.0001). Survival curves also showed that sucralfate was significantly more effective in preventing relapse (p = 0.0001). Three patients were judged as experiencing drug-related side effects, two of which were in the placebo group. The results indicate that sucralfate is significantly more effective than placebo in the prevention of recurrence of duodenal ulcer disease.

Clinical Trials as Topic↗
PubMed1987

[Cystine calculi. In vitro solubility and chemical structure].

A series of cystine stones extracted from the same subject by pyelotomy was used to study the in vitro solubility of these stones in various solutions. Isotonic bicarbonated saline presented a definite dissolving action, but the stone dissolved relatively slowly alpha-mercapto-propionyl-glycine was much more active, even when mixed urine. N-acetylcystine had the same degree of effectiveness as alpha-mercapto-propionyl-glycine. One stone in this series, which was partially covered by a coating of calcium phosphate, dissolved much more slowly than the other stones. In subjects with cystine stones, longstanding large stones are frequently mixtures of phosphates and cystine and, in 21 cases, chemical analyses and infra-red spectrography demonstrated the presence of calcium phosphate on the surface or in the inferior of these stones, associated with ammoniaco-magnesium phosphate in three cases. The presence of phosphates makes oral medical treatment ineffective, but mixed stones are more friable than pure cystine stones and are therefore easier to treat by extracorporeal lithotripsy.

Chemical Phenomena↗
PubMed1987

Transfer dysphagia in a patient with the rare combination of scleroderma and ankylosing spondylitis.

Esophageal involvement in scleroderma is generally confined to the body, manifested manometrically as impaired motility and decreased lower esophageal sphincter tone. Pharyngeal dysfunction has not been recognized. This is a report of a patient with the rare combination of scleroderma and ankylosing spondylitis, whose presenting complaint was transfer dysphagia due to impaired relaxation of the upper esophageal spincter as a result of tight overlying cervical skin, or sclerodermatous involvement of the sphincter itself.

Deglutition Disorders↗
PubMed1986

Music therapy.

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Humans↗