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Biomedical subjects

E Taylor

Publications and source records attributed to E Taylor.

At least 73 records · Page 4Linked to original sources
PubMed1998

Clinical foundations of hyperactivity research.

Clinical research into the psychopathology of attention deficit/hyperactivity disorder (AD/HD) has established reliable measures of the defining behavioural problems: inattentiveness, overactivity, and impulsiveness. Experimental measures have defined them with increasing accuracy, but research is still needed before it is clear what processes need to be explained at the level of brain dysfunction. Understanding the associations of AD/HD, and the way they change over time, requires the approach of developmental psychopathology. This paper outlines some key concepts. The possible heterogeneity of AD/HD is stressed, with substantial differences being associated with the predominant type of symptom, the situations in which it is expressed, and the types of co-existing problems. Developmental influences on course need not be the same as initiating causes and a transactional model is outlined. Cultural and familial factors modulate the course of this biologically initiated disorder. Genetic influences appear to be strong and a combination of behavioural and molecular genetics with longitudinal study offers hope of advances in nosology.

Attention↗
PubMed1998

The effect of inhaled budesonide on the diurnal variation in airway mechanics, airway responsiveness and serum neutrophil chemotactic activity in Asian patients with predominant nocturnal asthma.

The effectiveness of inhaled corticosteroids in the control of daytime symptoms in asthma is well established, but the specific use against nocturnal asthma has not been systematically studied in Asian patients. This study examined the effect of treatment with inhaled budesonide on the nocturnal variation in measurements of airway calibre, bronchial hyperresponsiveness to inhaled histamine and circulating neutrophil chemotactic activity in Asian patients with nocturnal asthma. Thirty patients, with nocturnal asthma, were randomized into a 2-month, double-blind, parallel group study. Twice as many subjects were allocated to the group who received two consecutive months of inhaled budesonide 1600 microg daily as to the group who received placebo followed by budesonide. Spirometry, lung mechanics, bronchial hyperresponsiveness and serum neutrophil chemotactic factor (NCA) were measured at 16.00 h, 22.00 h and at 04.00 h on 3 days and nights, 4 weeks apart before and after either placebo or budesonide. The combined measurements for the two groups at 04.00 h before and after treatment with budesonide were: forced expiratory volume in 1 s (FEV1) mean (SEM) litres 1.34 (0.17) before, 2.00 (0.19) after; thoracic gas volume (TGV) litres 3.05 (0.32) before, 2.25 (0.14) after; specific airway conductance (sGaw) (cmH20.0 sec)(-1) 0.39 (0.07) before, 1.16 (0.17) after; PD20 microg geometric mean 1.16 before, 44.74 after; neutrophil chemotactic activity (NCA) in units of graduations of migration 98.8 (4.2) before, 101 (14.2) after. The data showed that short and intermediate term high dose inhaled budesonide is an effective specific treatment for nocturnal asthma in Asian patients, resulting in marked improvements in symptoms and in lung mechanics, and reductions in the diurnal variations in bronchial hyperresponsiveness, before any change could be demonstrated in a circulating marker of airway inflammation.

Administration, Inhalation↗
PubMed1998

Exaggerated free alpha-subunit levels during pulsatile gonadotropin-releasing hormone replacement in women with idiopathic hypogonadotropic hypogonadism.

The goals of this study were to determine whether women with idiopathic hypogonadotropic hypogonadism (IHH) respond to pulsatile GnRH replacement therapy with exaggerated glycoprotein free alpha-subunit (FAS) levels, as reported in GnRH-deficient men, and to determine whether this pattern is unique to congenital GnRH deficiency or is also characteristic of patients with hypogonadotropic hypogonadism caused by other factors. GnRH was administered i.v. at a physiologic frequency and dose (75-100 ng/kg.bolus) to women with IHH (n = 11; n = 6 with anosmia); acquired GnRH deficiency secondary to treatment for cranial tumors (AHH; n = 7); and secondary hypothalamic amenorrhea (HA; n = 8). Results were compared with 24 normal cycling women. Gonadotropins, sex steroids, and FAS levels were measured in samples drawn daily across induced or normal menstrual cycles in patients or normal women, respectively. Samples were drawn at the same time of day and were collected 45 min after a GnRH bolus in patients. All women ovulated in response to pulsatile GnRH. There were no differences in the patterns of LH or gonadal steroid secretion between any of the patient groups (IHH, AHH, and HA). The patterns of LH and FSH secretion in the induced patient cycles were not different from normal women, with the exception of lower midcycle FSH levels in IHH women (P < 0.002). However, the daily dynamic secretion of FAS was exaggerated in IHH (compared with AHH, HA, and normal) women (P < 0.002). The increase in FAS levels in IHH was dependent on cycle stage, with the greatest difference observed during the early (P < 0.005) and midfollicular phase (P < 0.05) and the early luteal phase (P < 0.05). There was no difference in FAS between groups during the late follicular phase, at the midcycle, or in the midluteal and late luteal phase. This exaggerated FAS response to GnRH replacement in IHH was demonstrated in repeat cycles in two patients. Conclusions are: 1) Women with IHH respond to pulsatile GnRH replacement with an exaggerated secretion of FAS, which seems to be modified by gonadal factors; 2) this exaggerated FAS response, which is similar to that seen in GnRH-deficient men, is unique to congenital GnRH deficiency, and it is not observed in patients with acquired or secondary hypogonadotropic hypogonadism, suggesting that IHH patients may be missing a factor, in addition to GnRH, which normally restrains FAS secretion; and 3) the FAS response may prove to be a useful marker to distinguish constitutional delay of puberty from congenital GnRH deficiency.

Adolescent↗
PubMed1998

Teamwork in the operating department.

The Gynaecology theatre team of the Leicester Royal Infirmary NHS Trust were runners-up in the 1997 3M/NATN joint award. This article is a report of their work on the concept of teamwork and its benefits to the organisation and delivery of patient care in the operating department.

Hospital Restructuring↗
PubMed1998

The parenting and family functioning of children with hyperactivity.

This study examined the parenting and family life correlates of childhood hyperactivity in a community sample of London school children. Twenty-eight boys with pervasive hyperactivity were compared to 30 classroom control children on a range of parenting and family functioning measures. Results showed that poor parent coping and the use of aggressive discipline methods were significantly associated with hyperactivity after adjusting for the effects of conduct disorder and parent mental health. The best parenting predictor of hyperactivity was disciplinary aggression. Findings suggest that the quality of parenting provided for hyperactive children may contribute to their behavioural difficulties, and highlights the need to examine more closely the role of parenting attitudes and behaviour in shaping the course, prognosis, and treatment outcomes for children with hyperactivity.

Adaptation, Psychological↗
PubMed1997

Medical classification systems in Canada: moving toward the year 2000.

The use of different standards for coding diagnoses and procedures has been identified as a major obstacle to the collection and analysis of data across the various jurisdictions in Canada. In this article the authors briefly describe the current and future situation of medical classification systems in Canada and discuss some of the potential benefits and implications of adopting the 10th revision of the International Statistical Classification of Diseases and Related Health Problems and a revised procedure classification, the Canadian Classification of Health Interventions, as national standards for classification systems in Canada. They further describe some of the key features of the proposed new classification systems and highlight some of the actions being taken by the Canadian Institute for Health Information to support implementation of these standards in Canada over the next few years.

Canada↗
PubMed1997

New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26.

Loss of heterozygosity on chromosome 10 is considered to be associated with the progression of glioblastomas. Two closely related regions have recently been proposed to contain the glioblastoma suppressor locus on chromosome 10q25-26; a 1 cM region between the polymorphic (CA)n-repeat markers D10S587 and D10S216, and an area of 5 cM between the markers D10S221 and D10S209. To confirm and further delineate this region, we analyzed 51 glioblastomas and 11 intermediate and low-grade gliomas for loss of heterozygosity on chromosome 10. 47/62 mostly malignant gliomas displayed complete loss of chromosome 10 and nine tumors were unaltered, whereas four glioblastomas and two low-grade oligodendrogliomas had partial loss on distal 10q. With these six tumors, we constructed a deletion map with increased marker density at 10q25-26 which shows two centromeric breakpoints at the markers D10S587 and D10S216, thus only confirming the distal, but not the proximal candidate glioblastoma suppressor locus. Two out of four low-grade oligodendrogliomas displayed partial deletions on 10q25-26. This suggests that deletion on chromosome 10 is not merely a late event in the progression of glioblastomas, but could play a role earlier in the development of gliomas.

Brain Neoplasms↗
PubMed1997

Bringing mind-body medicine into the mainstream.

Centuries-old concepts concerning the mind's influence on the body are being examined with renewed interest. As awareness of the health benefits of being able to voluntarily control vital aspects of the metabolic state increases, and as our understanding of the underlying molecular mechanisms of such control also increases, mind-body medicine may move further into the mainstream of Western medical practices.

Adult↗
PubMed1997

Empirical evaluation of genome scans for linkage of a quantitative trait associated with a complex disorder.

Nonparametric sib-pair analysis (Haseman-Elston) was used to search for evidence of linkage between a putative locus for a complex quantitative trait Q1 and genome-wide markers (367 markers from 10 chromosomes) for the first 100 replicates of nuclear family data. The characteristics of the statistically positive linkage results [the magnitude of p-values (p), the number of supporting flanking markers, and the percentage of positive replicates] were compared for true linkage (major and minor genes) and false positive evidence for linkage. Discriminant analysis was used to evaluate which characteristics of these statistically positive linkage results are good indicators to discriminate true linkage from false positive evidence for linkage. Sensitivity and false positive rates of several proposed criteria for linkage, as well as the criteria based on our results were evaluated. The relationship between the map location of the marker with the lowest p-value and the map location of the true underlying gene was also evaluated, which provided useful information for fine mapping and replication studies.

Age Distribution↗
PubMed1997

Temporary vehicle immobilization: evaluation of a program in Ohio.

Driving while suspended is a growing problem in most states. To deal with this problem, a number of jurisdictions are impounding and/or immobilizing the vehicles of driving while suspended or multiple driving under the influence offenders. This study evaluates the first 2 years of the implementation of this type of law in Franklin County (Columbus), OH. Variations in police enforcement and judicial sentencing policies resulted in some offenders, though eligible for impoundment or immobilization, not receiving the sanction. The recidivism rates of these offenders were compared with offenders who did receive a vehicle sanction. Tracking these two groups of offenders for up to 2 years demonstrated that the offenders who received the sanction had lower recidivism rates, both before and after they reclaimed their vehicles.

Accidents, Traffic↗
PubMed1997

Liver iron depletion and toxicity of the iron chelator deferiprone (L1, CP20) in the guinea pig.

The use of the iron chelator deferiprone (L1, CP20, 1,2-dimethyl-3-hydroxypyrid-4-one) for the treatment of diseases of iron overload and other disorders is problematic and requires further evaluation. In this study the efficacy, toxicity and mechanism of action of orally administered L1 were investigated in the guinea pig using the carbonyl iron model of iron overload. In an acute trial, depletion of liver non-heme iron in drug-treated guinea pigs (normal iron status) was maximal (approximately 50% of control) after a single oral dose of L1 of 200 mg kg-1, suggesting a limited chelatable pool in normal tissue. There was no apparent toxicity up to 600 mg kg-1. In each of two sub-acute trials, normal and iron-loaded animals were fed L1 (300 mg kg-1 day-1) or placebo for six days. Final mortalities were 12/20 (L1) and 0/20 (placebo). Symptoms included weakness, weight loss and eye discharge. Iron-loaded as well as normal guinea pigs were affected, indicating that at this drug level iron loading was not protective. In a chronic trial guinea pigs received L1 (50 mg kg-1 day-1) or placebo for six days per week over eight months. Liver non-heme iron was reduced in animals iron-loaded prior to the trial. The increase in a wave latency (electroretinogram), the foci of hepatic, myocardial and musculo-skeletal necrosis, and the decrease in white blood cells in the drug--treated/normal diet group even at the low dose of 50 mg kg-1 day-1 suggests that L1 may be unsuitable for the treatment of diseases which do not involve Fe overload. However, the low level of pathology in animals treated with iron prior to the trial suggests that even a small degree of iron overload (two-fold after eight months) is protective at this drug level. We conclude that the relationship between drug dose and iron status is critical in avoiding toxicity and must be monitored rigorously as cellular iron is depleted.

Administration, Oral↗
PubMed1997

Epidemiological study of hospital-acquired infection with vancomycin-resistant Enterococcus faecium: possible transmission by an electronic ear-probe thermometer.

Clonal spread of vancomycin-resistant Enterococcus faecium among seven patients on one ward of a community teaching hospital was identified by contour-clamped homogeneous electric-field gel electrophoresis. Environmental cultures isolated the same strain from the handle of a shared electronic ear-probe thermometer. Cross-contamination of the clonal strain between two geographically separate units on this ward, sharing equipment but not personnel, suggests the possibility of an environmental source.

Case-Control Studies↗
PubMed1997

Child and family factors influencing the clinical referral of children with hyperactivity: a research note.

This study examined child and family factors associated with the clinical referral of pervasively hyperactive children. Fourteen children with pervasive hyperactive behaviour problems referred to a London child guidance service were compared with 13 nonreferred pervasively hyperactive children resident in the same geographic area. Child behaviour, parenting, and family life factors were examined as determinants of referral. Preliminary results suggest that both child and parenting factors play an important role in determining whether a child with hyperactivity will be referred for child guidance. The best predictors of clinical referral were a parent's ability to cope with child behaviour, child emotional disturbance, school relationship problems, and parental disciplinary indulgence. Implications of referral bias for research and service planning are discussed.

Adaptation, Psychological↗
PubMed1997

Models of shiftwork and health: an examination of the influence of stress on shiftwork theory.

This paper critically reviews models of shiftwork and health and provides a historical overview of changes in the conceptualization of the association between them. Models are hypothetical and conceptually broad, becoming more so as they move away from linear, chronobiological to multidirectional, psychological conceptualizations. We attribute this tendency to the use of stress frameworks to explain the relationship between shiftwork and health. We assess the usefulness of stress as an explanatory concept in terms of how it affects shiftwork research and practice and make recommendations for future practice and theory development.

Adaptation, Physiological↗
PubMed1997

Drug treatment: explaining the gender paradox.

There is something of a gender paradox in drug user treatment. Research consistently indicates that women possess "risk factors" associated with drug use relapse, yet women are no more likely, and possibly less likely, to relapse to drug use. Efforts to explain this paradox involve a longitudinal study of 330 women and men participating in outpatient drug-user treatment associated with the evaluation of the Los Angeles Target Cities Project funded by the Center for Substance Abuse Treatment. The findings offer no support for the drug severity and social support hypotheses, but some support for the treatment engagement hypothesis. Specifically, women participate more frequently in group counseling which, in turn, lowers their rate of relapse in spite of having more "risk factors." Further analyses indicate that the greater participation of women in group counseling does not stem from child-custody or other gender differences in the reasons for entering treatment, nor does it result from the enhanced services associated with the Target Cities Project. Rather, the differences in treatment engagement for women and men may result from gender norms concerning help-seeking, personal independence, strength, and control. The treatment and policy implications of these findings and recommendations for further research are discussed.

Adolescent↗
PubMed1997

Helper T-lymphocyte count. TRAx CD4 test kit versus conventional flow cytometry.

BACKGROUND: We evaluated a newly developed enzyme-linked immunosorbent assay system for measuring helper T-lymphocyte count. METHODS: Data from 111 human immunodeficiency virus-infected injection drug users in a cohort study were analyzed by flow cytometry and independent duplicate runs of the TRAx enzyme-linked immunosorbent assay. RESULTS: The mean helper T-cell counts were 470, 480, and 506 per microliter by flow cytometry and TRAx runs 1 and 2, respectively. The correlation coefficients for TRAx runs 1 and 2 with the flow cytometry results as the dependent variable were .93 and .91, respectively. A cross-tabulation of the enzyme-linked immunosorbent assay helper T-lymphocyte counts with flow cytometry counts showed agreement of 71% and 76% when the flow count was between 201 and 500, and 88% and 90% when it was greater than 500 cells per microliter. In those samples with 200 or fewer helper T cells, agreement was 73% and 41% for each TRAx run. CONCLUSIONS: The TRAx enzyme-linked immunosorbent assay system is an acceptable method for measuring helper T-lymphocyte count, but should be recalibrated for better performance at helper T-cell counts below 200 per microliter.

CD4 Lymphocyte Count↗