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Biomedical subjects

E Taubøll

Publications and source records attributed to E Taubøll.

13 recordsLinked to original sources
PubMed1994

Acute effects of 17 beta-estradiol on brain excitability studied in vitro and in vivo.

The acute effects of 17 beta-estradiol on brain excitability were studied in vitro and in vivo utilizing rat hippocampal slices and a cat cerveau isolé preparation. The hippocampal slices were perfused with 17 beta-estradiol (10(-7)-10(-10) M) for 30 min. No effects were observed on synaptic activation and inhibition and on the response to iontophoretically applied GABA in intact and ovariectomized female rats (n = 43). In males (n = 32), however, a small (12%) but significant increase in population spike amplitude was observed after 30 min exposure to 10(-9) M 17 beta-estradiol. Higher and lower concentrations were ineffective. In vivo, no acute effects of 17 beta-estradiol on focal epileptic seizure thresholds, evoked potentials, or augmenting response were observed in the visual cortex of non-estrous female cats (n = 11; median dose 1 micrograms/kg, range 0.5 microgram/kg-10 mg/kg).

Animals↗
PubMed1993

The progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one reduces K(+)-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: a semiquantitative immunocytochemical study.

5 alpha-Pregnan-3 alpha ol-20-one (3 alpha-OH-DHP) reduced the depolarization-induced loss of GABA and, to a lesser extent, the glutamate-like immunoreactivities from nerve terminals in the in vitro hippocampal slice. Phenobarbital (PB) had similar effects. These results suggest that 3 alpha-OH-DHP affects presynaptic transmitter release, possibly in a barbiturate-like manner.

Animals↗
PubMed1993

The effect of progesterone and its metabolite 5 alpha-pregnan-3 alpha-ol-20-one on focal epileptic seizures in the cat's visual cortex in vivo.

The acute effects of progesterone and its brain metabolite 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha-OH-DHP) on focal epileptic seizures in the cat's visual cortex was studied in vivo using an unanesthetized cervaux-isolé preparation. This model made it possible to study in parallel the effect of the drugs on ictal activity and synaptic transmission. A dose-dependent increase in seizure threshold was observed after i.v. injections of both 3 alpha-OH-DHP and progesterone, 3 alpha-OH-DHP being about 20 times as potent as the latter. I.v. injections of 3 alpha-OH-DHP 1.0 mg/kg increased the median seizure threshold to 265% of baseline. While 3 alpha-OH-DHP exerted an immediate effect on seizure thresholds, the maximal effect of progesterone was delayed about 20 min. Concerning the mechanisms underlying the antiepileptic effect, three changes occurred within the effective dose range: (1) a small, but significant reduction in the presynaptic nerve volleys, (2) a reduction in the postsynaptic excitatory field potentials in the dorsal lateral geniculate nucleus and cortex, and (3) an enhanced postsynaptic inhibition. Taken together, these observations point to both pre- and postsynaptic effects, supporting the hypothesis of a barbiturate-like mechanism of action of progesterone and its brain metabolites.

Animals↗
PubMed1991

Temporal distribution of seizures in epilepsy.

A major problem in epileptology is why a seizure occurs at a particular moment in time. An initial step in solving this problem is a detailed analysis of the temporal distribution of seizures. Using methods and theories of stochastic processes, seizure patterns in a group of epileptic outpatients were examined for stationarity, randomness, dependency and periodicity in a prospective study. Sixteen of the 21 seizure diaries included in the study showed stationarity; 2 were non-stationary and 3 inconclusive. Eleven of the 16 stationary diaries were non-Poisson (P less than 0.005), indicating that in the majority of patients seizures did not occur randomly. The most frequently encountered phenomenon was seizure clustering. Clustering was considered when the diaries fulfilled all three criteria: (1) a positive R-test (P less than 0.001); (2) deviation from the fitted Poisson distribution towards clustering; and (3) the feature of an autoregressive process in the autocorrelogram plot. Dependency between seizure events was demonstrated in 8 of the 16 stationary diaries, computing first order transition probabilities. A detailed analysis of seizure occurrence is a major step towards a better understanding of the mechanisms underlying seizure precipitation. This is exemplified by our finding of a relation between seizure frequency and the menstrual cycle.

Adolescent↗
PubMed1987

[Adie's syndrome].

Explore the source record for details and available documents.

Adie Syndrome↗
PubMed1987

Effects of electroconvulsive therapy (ECT) on thyroid function parameters.

Serum concentrations of thyroxine, triiodothyronine, TSH and prolactin were measured in 10 patients with affective disorders receiving ECT. Samples were drawn at -15 min, 0, +30 min, +60 min and +3 hr after ECT. A significant increase in both prolactin and TSH was observed 30 min after ECT. A small but significant decrease in triiodothyronine but no change in thyroxine was found in all post-ECT samples. The increase in TSH may be caused by an anti-dopaminergic effect of ECT at either the pituitary or the hypothalamic level.

Adult↗
PubMed1986

No monthly variations in serum levels of thyroid hormones in human males.

There have been very few reports on rhythmic variation in thyroid hormone concentrations with a periodicity of 4-6 weeks. In an attempt to evaluate whether such a rhythm is a general phenomenon we studied ten healthy male students with weekly blood samples over 12 weeks for T4, T3 and TSH. No rhythmicity could be demonstrated.

Adult↗
PubMedDate not supplied

A new injectable carbamazepine solution--antiepileptic effects and pharmaceutical properties.

Carbamazepine (CBZ) could be dissolved in Glycofurol (polyethylene glycol monotetra-hydrofurfuryl ether) with concentrations up to 100 mg/ml, and the solutions were stable for at least 14 days. Ethanol or benzyl alcohol was added without loss in solubility, while water, human serum albumin or Intralipid always led to immediate precipitation. The effect of a CBZ/Glycofurol solution on focal seizure threshold in the visual cortex in cats was investigated using a cerveau isolé preparation. Fourteen experiments were performed using i.v. injections of CBZ with concentrations ranging from 0.2 to 20 mg/kg. In all experiments with doses greater than 1 mg/kg the CBZ/Glycofurol injections exerted a pronounced and immediate effect on the seizure threshold, while Glycofurol alone was ineffective. On average, seizure threshold increased more than 5-fold with doses in the range of 5-20 mg/kg. Investigating the effect of CBZ/Glycofurol on picrotoxin-induced seizure activity in cats, 2 injections of 5 mg/ml of CBZ immediately stopped the seizure activity as evaluated by electrocorticography, while interictal activity remained.

Animals↗
PubMedDate not supplied

Association between regularly occurring complex partial seizures and thyroid function parameters.

A 28-year-old man with regularly occurring clusters of complex partial seizures was studied over a total of 224 days. His seizure periods lasted 2-4 days and occurred at intervals of 5-6 weeks. Several parameters were studied. The most striking finding was an increase in the serum concentration of thyroxine prior to and during the seizure periods. The concentrations of urine catecholamines and serum cortisol also varied with the seizure periods, but these hormones increased after the seizure periods had begun. To determine if there is a general 4-6-week rhythm in thyroid hormone concentrations, 12 weekly blood samples from 10 healthy male students were analyzed. No rhythmicity was found.

Adult↗
PubMedDate not supplied

Triiodothyronine and brain excitability.

We investigated mechanisms involved in thyroid hormone action on brain excitability. The effect of acute exposure of triiodothyronine (T3) to rat hippocampal slices in vitro was studied. No significant changes could be detected in prevolley, field excitatory postsynaptic potentials (fEPSP) and population spike amplitude, while there was a minor, nonsignificant trend toward shortening of the population spike latency time. T3 had no effect on penicillin-induced epileptiform activity. There was, however, an active accumulation of radioactively labeled T3 in the slices. A rat cervaux-isolé preparation was used to determine focal seizure thresholds in the visual cortex, and no acute (2-4 h) effects were demonstrated. No significant acute effects of T3 on brain excitability in the hippocampus and visual cortex was observed, despite an active accumulation of T3. Thus, the effect of T3 on brain excitability most likely is due to delayed effects.

Animals↗
PubMedDate not supplied

Comparison of 5 alpha-pregnan-3 alpha-ol-20-one and phenobarbital on cortical synaptic activation and inhibition studied in vitro.

The effects of 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha-OH-DHP) and phenobarbital (PB) on synaptic excitation and inhibition in rat hippocampal slices in vitro were compared. Stimulations were made orthodromically and antidromically while we recorded extracellularly from the dendritic and the somatic layer of the CA1 region. Perfusion with 5 micrograms/ml of 3 alpha-OH-DHP for 30 min significantly increased the recurrent inhibition evoked by antidromic stimulation. The effect was most pronounced at short interstimulus intervals. The duration of the recurrent inhibition also was prolonged. There was no effect on the conditioned population spike after orthodromic paired-pulse stimulation. Furthermore, no effect was observed on the amplitude of the orthodromic fiber volley, the rate of increase in the field excitatory postsynaptic potential (EPSP) and the latency and amplitude of the CA1 population spike. Qualitative and quantitative similar findings were observed during perfusion with PB 0.1 mg/ml, (i.e., a concentration 20 times higher than that of 3 alpha-OH-DHP). Higher concentrations of PB also affected synaptic excitation. The findings suggest a similar effect of 3 alpha-OH-DHP and PB on recurrent GABA-ergic inhibition; however, 3 alpha-OH-DHP appears to be much more potent.

Animals↗