Biomedical subjects

E Tarkiainen

Publications and source records attributed to E Tarkiainen.

12 recordsLinked to original sources

PubMed1979

Diagnostic procedures in chronic rhinitis.

Various methods of diagnosing allergic factors in chronic rhinitis are discussed. Among the procedures which aim at detecting specific allergens, i.e. skin testing, RAST, and nasal provocation tests, the last mentioned, as they are performed directly on the shock organ, have so far been found to give the most accurate picture of clinically dominant allergens and of the intensity and character of the rhinitis. However, information obtained by analysing the correlations between different procedures is not unanimous. As long as test techniques and allergen extracts have not been standardized, one particular test cannot be recommended as the method of choice.

Allergens↗

PubMed1979

The most important allergens in allergic rhinitis.

The distribution of allergens, found on thorough allergy work-up in a series of 770 patients with seasonal and perennial nasal symptoms, is reported. The percentages of positive reactions to grass, tree, and herb pollens were equally high (30--40%) but, clinically, pollens from grasses (Timothy, Alopecurus, Kentucky Blue and Meadow fescue), birch and mugwort (Artemisia) were the most important. In the Nordic countries house dust is evidently the commonest causative agent in perennial rhinitis but the heterogenous composition of house dust makes it difficult to determine potent allergenic factors. Sensitivity to house dust was present in 44% of the patients; a positive reaction to mite extract in only 10%. Animal danders were not found to be great importance in allergic rhinitis (13--18%). Reactions to moulds were observed in 9% of the patients.

Allergens↗

PubMed1977

Experiences of treating allergic rhinitis with intra-nasal beclomethasone dipropionate. Short-term trials and long-term follow-up.

The effect of locally acting intra-nasal beclomethasone dipropionate was observed in 42 patients suffering from seasonal allergic rhinitis and 50 patients suffering from perennial rhinitis. The study consists of three parts: 1) a simple double-blind trial in seasonal rhinitis, 2) a double-blind crossover trial in perennial rhinitis, 3) a 1-year follow-up of the perennial group. The active drug was significantly superior to placebo when comparing subjective symptoms, nasal resistance and secretion eosinophilia in the patients. In long-term use it was possible to reduce the initial dose considerably. On objective examination no significant changes were seen in the epithelium following long-term use. No suppression of the hypothalamic-pituitary-adrenal axis was observed after 1 year's regular use of beclomethasone dipropionate. The side effects were mild, the most common complaint being irritation of the nasal mucous membrane, apparently caused by the propellant gas.

Administration, Intranasal↗

PubMed1976

Nasal challenge.

Seven years' experience of nasal challenge is presented. On the basis of a material of 1492 controlled provocation tests performed on 715 patients, practical problems concerning the performance period of the provocation, application methods, allergen preparations, interpretation of the results as well as the relevance and correlation of different investigation methods of allergic rhinitis are discussed.

Allergens↗

PubMed1970