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Biomedical subjects

E Tanaka

Publications and source records attributed to E Tanaka.

At least 613 records · Page 34Linked to original sources
PubMed1978

[A new method of measuring the system intrinsic variance of scintillation detectors (author's transl)].

A new method is described for the measurement of the system intrinsic variance of scintillation detectors. The system intrinsic variance can be obtained by subtracting the component of photomultiplier variance from the total (observed) variance of detector pulse amplitude; the former component has usually been determined by the use of a light pulser. In the present method, two photomultiplier tubes are optically coupled to a scintillator which is irradiated by a collimated beam of gamma-rays, and the system intrinsic variance is determined from the analysis of mutual correlation of pulse amplitude between the outputs of these two photomultiplier tubes. The method does not need the use of a light pulser, and is able to discriminate the effect of multiple interaction of gamma-rays in the scintillator. A preliminary experiment with a cylindrical NaI(Tl) crystal (4 cmphi X 10 cm) has been performed for a range of gamma-ray energy from 60 keV to 835 keV. The result is well consistent with ones reported by other authors using light pulsers.

Gamma Rays↗
PubMed1978

[Fundamental and clinical studies in pediatrics on PC-904, a penicillin with broad spectrum newly developed in Japan (author's transl)].

Fundamental and clinical studies of PC-904, a newly developed penicillin with a broad spectrum, were performed and the following results were obtained. (1) The serum levels of PC-904 after 1.5 hours drip infusion reached the peak at 1 hour or at the end of the infusion and the detectable levels of PC-904 were maintained up to 2 or 3 hours after the end of the infusion. (2) The urinary excretion rates up to 6 hours after the onset of the infusion were 19.2 approximately 25.5%. (3) Forty-one patients were treated with PC-904 and the majority of the diseases were acute respiratory infections. The treatment by the drip infusion of 50 approximately 100 mg/kg/day resulted in good responses to whooping cough, and lacunar tonsillitis, lymphadenitis and staphylococcal scald skin syndrome resistant to the treatment by ampicillin and cephalexin. The satisfactory results were also obtained by the treatment of almost the same dosage in the patients with acute bronchitis, bronchopneumonia and measles pneumonia. (4) Staphylococcus aureus and Klebsiella pneumoniae were isolated from the sputum culture of the patients with bronchopneumonia and they responded well to the treatment with PC-904. (5) The drip infusion of 60 approximately 70 mg/kg/day for 5 approximately 6 days was shown to be useful in the treatment of urinary tract infection of which the causative organism was E. coli. (6) No side effects were observed except rubella-like eruption in one case. (7) Clinical evaluation was examined in all cases except one patient of which the medication was withdrawn due to eruption, and the overall clinical efficacy was excellent or good in all of 40 cases.

Age Factors↗
PubMed1977

Amino acid sequences of the aplpha and beta chains of adult hemoglobin of the tupai, Tupaia glis.

Globin prepared from hemoglobin of adult tupai (Tupaia glis) was separated into alpha and beta polypeptide chains by CM-cellulose column chromatography. The S-aminoethylated alpha polypeptide chain and S-carboxymethylated beta polypeptide chain were each digested with trypsin, and the sequences of all the peptides thus obtained were established. The ordering of these tryptic peptides in the alpha and beta polypeptide chains was deduced from the homology of their primary structures with that of human adult hemoglobin. In this way the primary structures of the alpha and beta polypeptide chains of tupai hemoglobin were established; 27 amino acids in the alpha polypeptide chain and 26 in the beta chain differ from those in human adult hemoglobin.

Amino Acid Sequence↗
PubMed1976

Hyperdibasicaminoaciduria and hyperammonemia in familial protein intolerance.

A 3-year-old boy with hyperdibasicaminoaciduria and hyperammonemia showed characteristics of familial protein intolerance (FPI). Oral loading tests of lysine and arginine disclosed a remarkably reduced capability for intestinal absorption of these amino acids. Because urinary excretion and renal clearance of dibasic amino acids were only moderately elevated in the patient, the conspicuously decreased serum concentration of lysine, arginine, and ornithine was attributed to the defect in internal absorption. A possible explanation for elevated blood ammonia levels in FPI is that it is due to a deficiency of arginine and ornithine in the urea cycle that in turn results from a severe impairment in absorption of the amino acids by the gut mucosa.

Amino Acid Metabolism, Inborn Errors↗
PubMed1975

Correction functions for optimizing the reconstructed image in transverse section scan.

Two correction functions are derived for one- and two-dimensional convolution methods for reconstructing a section image from multiple projections. The functions are optimized to yield a maximum 'signal-to-noise power ratio' for a given RMS resolution width, where 'signal power' is the integrated squared line spread function (signal power regarding one-dimensional position information per count) and 'noise power' is the variance of the image density at the centre of a locally uniform source. The point spread function of the reconstructed image is Gaussian, and the standard deivation of noise associated with a locally uniform image is found to be proportional to D-3/2, where D is the RMS resolution width. The autocovariance function for uniform noise is also given.

Mathematics↗