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Biomedical subjects

E Tala

Publications and source records attributed to E Tala.

At least 55 records · Page 3Linked to original sources
PubMed1982

Enzyme-linked immunosorbent assay (ELISA) for antibodies to purified protein derivative of tuberculin (PPD). IgM-, IgA- and IgG- anti-PPD antibodies in active pulmonary tuberculosis.

Enzyme-linked immunosorbent assay (ELISA) was developed for IgM, IgA and IgG antibodies against purified protein derivative of tuberculin (PPD). PPD antibodies of 44 patients with active pulmonary tuberculosis were measured at admission to hospital. The control material consisted of 35 healthy blood donors. The mean antibody levels in all three immunoglobulin classes correlated to the extent of the tuberculous infection, i.e. the severer the disease the higher the mean antibody level. The mean antibody levels also were significantly higher in the tuberculosis patients than in the controls, the only exception was specific IgA antibodies in the patients with minimal disease. ELISA-positivity of the patients, i.e. positive result in at least one immunoglobulin class was as follows: 33% of the grade I, 64% of the grade II and 100% of the grade II patients.

Adult↗
PubMed1981

The effect of enzyme induction on the metabolism of disopyramide in man.

1 The effects of rifampicin, phenytoin, and disopyramide treatments on the metabolism of disopyramide were studied in patients and volunteers. 2 Rifampicin treatment markedly increased the metabolism of disopyramide. 3 Phenytoin had effects similar to those of rifampicin. The effect subsided in 2 weeks after stopping the treatment. 4 The metabolism of disopyramide seemed fastest in the patient group with the higher dose of disopyramide. Both in patients and volunteers a significant increase occurred in the urinary mono-N-dealkyldisopyramide/disopyramide ratio during the first week of disopyramide therapy. This change can partly be due to pharmacokinetic differences between disopyramide and its metabolite. The inducing effect of disopyramide remained uncertain.

Adult↗
PubMed1981

Interaction between proxyphylline and salbutamol.

Salbutamol increased significantly the bronchodilating effect of proxyphylline both in experimental animals and in asthmatic patients. In guinea pigs (modified Konzett-Rössler method) the reduction in response to metacholine caused by increasing doses of proxyphylline and salbutamol significantly exceeded that of either drug alone. In a double-blind, randomized cross-over study conducted on 3 consecutive days, asthmatic patients received 500 mg proxyphylline orally three times daily. On the 2nd or 3rd day a significantly greater improvement in the peak expiratory flow was found after the combination of proxyphylline and salbutamol (3 mg p.o.) in comparison with proxyphylline and placebo. Salbutamol had no significant effect on the plasma concentrations of proxyphylline, which varied between 14 and 22 microgram/ml. The combination of oral proxyphylline and salbutamol is clinically useful in increasing drug response without increased adverse effects.

Adolescent↗
PubMed1979

Pulmonary infiltrates associated with gold therapy. Report of a case.

A case report is presented concerning diffuse pulmonary infiltrates due to sodium aurothiomalate therapy in a 67-year-old woman suffering from rheumatoid arthritis. After the gold treatment was stopped, prednisolone therapy produced complete remission of the pulmonary reaction.

Aged↗