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Biomedical subjects

E Takazakura

Publications and source records attributed to E Takazakura.

At least 55 records · Page 3Linked to original sources
PubMed1989

Hepatic granulomata in long-term hemodialysis patients with hyperaluminumemia.

We describe two long-term hemodialysis patients with hyperaluminumemia, in whom multiple granulomata were found in the livers at autopsy. The granulomata were mainly composed of modified macrophages, and aluminum was constantly detected in the cytoplasm of these macrophages by histochemical analysis, as well as by X-ray microanalysis. These granulomata were also found in the spleen and lymph nodes. The constant presence of aluminum in the mononuclear phagocytic system might have been followed by the development of granulomata. Functional disturbances of the liver were not evident.

Adult↗
PubMed1988

Silent thyroiditis: a histologic and immunohistochemical study.

Twenty-six specimens obtained from 23 patients with clinically and laboratory-proven silent thyroiditis were examined histologically; 11 specimens were obtained during the thyrotoxic phase, and 15 specimens during the early or late recovery phase. All specimens showed chronic thyroiditis, focal or diffuse type; and lymphoid follicles were present in about half of the specimens. Most specimens showed neither stromal fibrosis nor oxyphilic cell changes. The follicular disruptions, which varied from moderate to severe and involved nearly all the visible follicles, were characteristic and common histologic features of this disorder. Giant cells were present in about two thirds of specimens. Six of the 7 specimens taken during the late recovery phase showed no follicular disruption. In 3 patients who had follow-up biopsies, the histologic involvement in the initial biopsy specimens clearly had disappeared in the second biopsy specimens. These histologic features indicate that silent thyroiditis may be a form of chronic thyroiditis, i.e., "chronic thyroiditis with marked follicular destruction." Thyroid biopsy is recommended as a useful tool in differentiating this disease from other thyroid diseases causing hyperthyroidism. In addition to the histologic analysis, intrathyroidal lymphocyte subsets were examined immunohistochemically and compared to those in chronic thyroiditis (Hashimoto's thyroiditis). In both silent and chronic thyroiditis, a great majority of lymphocytes infiltrating between thyroid follicles showed a T-cell phenotype, and no significant differences in T-cell and B-cell distribution between the diseases were observed.

Antibodies, Monoclonal↗
PubMed1986

Hepatocellular carcinoma with metastatic gastric cancer simulating Borrmann type 2 and hyperlipidemia.

A case of hepatocellular carcinoma with metastasis to the stomach and hyperlipidemia as a paraneoplastic syndrome was presented. The patient, a 69-year-old man, was admitted to Kurobe City Hospital with a complaint of epigastralgia. He was diagnosed as having hepatocellular carcinoma by an increased plasma AFP and the abnormalities of hepatic scintigram and abdominal angiography. Endoscopic examination of the stomach revealed an ulcerative lesion suggesting Borrmann type 2 gastric cancer and the gastric mucosal biopsy was interpreted as tubular adenocarcinoma. At autopsy, the liver was enlarged and weighed 4,170 g without liver cirrhosis. Histologic finding of the liver tumor was hepatocellular carcinoma of Edmondson's grade 2 and the gastric tumor with bile production was identical to that of liver tumor. The tumor architecture of the stomach, however, was mixed with trabecular pattern and tubular pattern near the site of gastric mucosa, and was concordant with the findings of gastric mucosal biopsy. Multiple tumor thrombi in the portal system suggested that hepatocellular carcinoma retrogradely metastasized to the stomach through the portal system.

Adenocarcinoma↗
PubMed1986

Renal and prostatic malakoplakia associated with submassive hepatic necrosis. A case report with immunocytochemical, ultrastructural and X-ray analytical observations.

An autopsy case of malakoplakia involving the kidney and prostate was reported. The case was a 58-year-old Japanese male with submassive hepatic necrosis of three and half months' duration. He received 20 to 40 mg of prednisolone daily during the course of the disease (total 2,700 mg). Malakoplakic lesions were incidentally found in the right renal parenchyma and prostate at autopsy. The lesions were characterized microscopically by an accumulation of macrophages with PAS-positive intracytoplasmic granules and with intracytoplasmic inclusions of owl's eye appearance called Michaelis-Gutmann bodies and, electronmicroscopically, by numerous phagolysosomes with varying numbers of bacteria. Immunocytochemical stain revealed that the bodies were positive for lysozyme, indicating that the Michaelis-Gutmann bodies are of lysosomal origin. No calcium, phosphorous, and iron were demonstrated in them by X-ray microanalysis, suggesting that they are of immature form in which a mineralization does not take place as yet. Malakoplakia has not been previously described in association with submassive hepatic necrosis. Administration of a large amount of steroid for the treatment of submassive hepatic necrosis was suspected to be implicated in the development of the malakoplakia in the present case.

Electron Probe Microanalysis↗
PubMed1986

[A case of polyradiculoneuropathy associated with diffuse arterial narrowing].

A 32-year-old female was admitted complaining of pain over the whole body and dysesthesia in all extremities. On admission, physical examination revealed hypertension, tachycardia, abdominal distension and urinary retention. Neurological examination revealed sensory impairment over the whole body and mild muscular weakness with absent deep tendon reflexes. Abdominal roentgenogram showed gaseous distension of the bowels. CT scans showed low density areas on the bilateral parieto-occipital lobes. CAG showed diffuse narrowing of the cerebral arteries. Laboratory examinations showed an albumino-cytologic dissociation (cells; 21/3mm, prot.; 78 mg/dl) of the cerebrospinal fluid and increased levels of norepinephrine (214 micrograms/day) and epinephrine (16.1 micrograms/day) in the urine. Motor nerve conduction velocities of the median nerves was 42.8 m/sec in the right and 50.0 m/sec in the left. The autonomic function tests revealed hyper-responsiveness to 10 mg of phentolamine and low baroreflex sensitivity. Within 2 months, most symptoms improved. Repeated CT scans showed no abnormality, while CAG showed only mild arterial narrowing. This case was diagnosed as having acute autonomic and sensory neuropathy which was a subtype of acute polyradiculoneuritis. Occult encephalitis or autonomic dysfunction was considered to contribute to the peculiar findings on CT and CAG.

Adult↗
PubMed1985

Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.

Following the observation of two fraternal patients without neurologic symptoms, but with hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in erythrocytic and nonerythrocytic cells, a familial study of their paternal and maternal relatives was undertaken. Ferrihemoglobin reductase activities in erythrocytes from the two patients were found to be impaired, and cytochrome b5 reductase activities in platelets and leukocytes were essentially absent. Any deficiencies of the enzyme activities seemed not to be found in nonhematopoietic cells. The enzyme activities in blood cells derived from the parents and some of their paternal and maternal family members showed levels intermediate between those of the patients and those of the normal control, which seemed to be heterozygous. The present cases did not belong to either the classic erythrocytic or the generalized type, and their enzyme deficiency was found rather to be restricted to their blood cells and not associated with neurologic and mental disorders. A necessity of diagnosis by tissues other than blood cells is discussed for a severe form of generalized-type hereditary methemoglobinemia with associated neurologic and mental disorders.

Adult↗