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Biomedical subjects

E T Yin

Publications and source records attributed to E T Yin.

At least 19 recordsLinked to original sources

Development of Xa inhibitor activity in relation to postoperative deep vein thrombosis (DVT).

65 patients, undergoing hip or elective general surgery, were tested for Xa inhibitor activity using a differential assay. Classification into minor and major deep vein thrombosis (DVT) was made. This study indicates that patients with repeatedly decreased Xa inhibitor activity during the first two days after trauma are highly disposed to develop postoperative DVT. In 10 out of 14 major DVT this decreased Xa inhibitor activity was observed before any detection of DVT by objective tests was possible.

Dextrans

Endotoxin, thrombin, and the Limulus amebocyte lysate test.

The Limulus amebocyte lysate, a proteinaceous composite isolated from the hemolymph cells of the horseshoe crab (Limulus polyphemus) is sensitive to picogram quantities of Gram-negative bacterial lipopolysaccharides. However, a controversy currently exists as to whether the Limulus amebocyte lysate is specifically sensitive to Gram-negative bacterial endotoxins as a result of a recent report that the blood coagulation protease, thrombin, can mimic endotoxins in the Limulus amebocyte lysate test. Experiments including those employing two highly purified fractions isolated from the Limulus lystae have provided us with evidence that thrombin per se is unable to mimic endotoxin.

Animals

Thrombin-time test.

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Blood Coagulation