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Biomedical subjects

E T Stewart

Publications and source records attributed to E T Stewart.

At least 55 records · Page 3Linked to original sources

Evaluation and treatment of intraabdominal bilomas.

In a 3-year period, 21 intraabdominal bilomas developed in 18 patients. Fifteen of the patients had a solitary biloma, and the other three patients each had two separate concurrent bilomas. The major cause of biloma formation was postoperative bile leakage from a bile duct after laparotomy done primarily for surgery on the gallbladder or liver. Maximal diameter of the bilomas in the transaxial plane ranged from 2 to 19 cm. Sixteen of the bilomas were in the right upper quadrant, and five were in the left upper quadrant. Two large right-sided collections extended caudally into the lower abdomen. The contours of the bilomas were configured by the diaphragm, mesenteries, liver, and other abdominal organs. On CT and sonography, the bilomas were invariably well demarcated, but most did not have an identifiable capsule. CT did demonstrate a thin rim on four bilomas and a thick rim on one. In 19 bile collections, the CT numbers were less than 20 H. The combination of the clinical history, the location, and the CT appearance of the lesion led to the correct diagnosis in each case. Percutaneous drainage was an effective form of therapy that often eliminated the need for surgical drainage.

Abdomen↗

Colonic perforation in renal transplant patients.

Review of 713 renal transplant patients at the Medical College of Wisconsin yielded 17 (2.3%) with spontaneous colon perforation. The cause seemed to be related to nonocclusive ischemia in the majority of cases (nine). The sigmoid colon was the most common site of perforation (nine cases). The early detection of colon perforation suspected on radiographic examination was associated with improved survival statistics.

Adolescent↗

Primary biliary carcinoma: CT evaluation.

Fifty-three patients with documented primary biliary carcinoma were studied with computed tomography. Twenty-six patients had gallbladder carcinoma and 27 patients had carcinoma of the biliary ductal system. Ninety percent of patients with gallbladder cancer had an intraluminal mass. Local invasion into the liver was common. The majority of patients with biliary ductal carcinoma had dilated bile ducts, while only 50% of patients with gallbladder cancer had biliary ductal dilatation. The most common location of tumor involving the extrahepatic biliary ductal system was the distal common bile duct. This occurred in eight patients out of 27, or 30% of the cases.

Adult↗

Endoscopic sphincterotomy: follow-up evaluation of effects on the sphincter of Oddi.

Endoscopic sphincterotomy (ES) alters the structure and motor function of the sphincter of Oddi (SO). The magnitude and duration of these changes, however, have not been critically examined. Before ES, 22 patients with common bile duct stones were evaluated by endoscopic retrograde cholangiography. The pressure gradient between the common bile duct and the duodenum, the SO basal pressure, and the SO peak phasic pressures were obtained. After ES, the electrosurgical incision length was determined using the extended papillotome and an inflated Fogarty balloon as reference. A high correlation existed between the endoscopist's estimate of ES incision size using this technique and the actual length of simulated incisions fashioned in cardboard mounts. These studies were repeated in all 22 patients at 1-yr follow-up and in 8 of these patients at 2-yr follow-up. At 12 mo and 24 mo after ES, the common bile duct (CBD) to duodenal pressure gradient and the sphincter of Oddi basal pressure were virtually eliminated. The amplitude of SO phasic contractions was significantly diminished 12 mo after ES (124 +/- 16 mmHg to 37 +/- 10 mmHg; p less than 0.001), but 24 mo after ES, SO phasic contraction amplitude was not significantly different from the values before ES. Incision length at 1-yr follow-up was reduced in the group of 22 patients from 11.6 +/- 0.8 mm to 8.3 +/- 0.5 mm (p less than 0.001), and in the group of 8 patients from 11.0 +/- 1.5 mm to 7.5 +/- 0.7 mm (p less than 0.025). After an additional 12 mo, however, i.e., 24 mo after ES, the incision length was 6.5 +/- 0.7 mm. There was no significant difference in incision length between the 12-mo and 24-mo examinations. We conclude that after ES, incision length decreases during the first year. There appears to be no further significant reduction in incision length at 2 yr. In addition, the reduction of the CBD to duodenal pressure gradient and the SO basal pressure remain unchanged for at least 2 yr. These manometric findings support the observation that after ES the enlarged opening of the CBD into the duodenum remains open for at least 2 yr.

Ampulla of Vater↗

Role of endoscopic retrograde cholangiopancreatography in the diagnosis and treatment of choledochocele.

Choledochocele is a rare abnormality involving the intramural segment of the common bile duct. It may present clinically as recurrent acute pancreatitis, biliary colic, or cholestatic jaundice. A choledochocele may be easily overlooked by the conventional diagnostic methods, such as upper gastrointestinal series, intravenous cholangiogram, abdominal ultrasound, and computed tomography. Endoscopic retrograde cholangiopancreatography is helpful in demonstrating a choledochocele. Additionally, in selected cases, a choledochocele may be effectively managed by endoscopic sphincterotomy. We present the clinical, endoscopic, and radiographic findings in a series of 8 patients with choledochocele. The radiologic technique most useful in demonstrating a choledochocele at the time of endoscopic retrograde cholangiopancreatography is detailed. The pathogenesis, differential diagnosis, and relevant current literature pertaining to choledochocele are discussed.

Aged↗

Work in progress: temporal energy hybrid subtraction in intravenous digital subtraction angiography.

A preliminary investigation of the feasibility and practical clinical utility of combined temporal energy (hybrid) subtraction for intravenous digital subtraction angiography (DSA) was performed in 19 selected patients. Studies of carotid, aortic arch, pulmonary, and aortorenal vessels were obtained. Soft-tissue misregistration artifacts were effectively removed with hybrid subtraction. Image integration was used to produce a signal-to-noise ratio equivalent to that of single frame temporal subtraction. Diagnostic improvements were produced in 20% of the examinations. Hybrid subtraction techniques resulted in an average increase of incident radiation dose to the skin of 15%.

Angiography↗

Digital subtraction angiography of the portal venous system.

Venous-phase arteriography after celiac or superior mesenteric artery injection is the most common technique used to demonstrate portal venous anatomy, flow direction, and portal systemic shunts. Large-volume contrast material injections and intraarterial vasodilators or balloon occlusion technique are required for optimal examinations using film-screen recording. A technique for performing venous-phase arteriography with digital subtraction imaging after celiac and superior mesenteric artery injection is described. The major advantage of intraarterial digital subtraction technique in comparison to film-screen recording is sensitivity to intravascular iodine with a consequent reduction in contrast material load and examination time. Technical success is limited only by motion artifact and should approximate the 80%-90% figure achieved for intravenous digital subtraction angiography of the aortorenal vessels.

Diatrizoate↗

Advances in the radiology of jaundice: a symposium and review.

New radiologic imaging and interventional techniques have transformed the clinical management of biliary obstruction. Selected aspects of their application were reviewed in a symposium conducted at the 12th annual meeting of the Society of Gastrointestinal Radiologists held recently at Banff, Alberta, Canada. There is a consensus that sonography is the preferred initial screening procedure for bile duct dilatation because of its accuracy and sensitivity although computed tomography more precisely displays the level and cause of obstruction. Transhepatic drainage provides effective decompression for malignant obstruction, but the high rate of postprocedure catheter dysfunction suggests that an indwelling endoprosthesis may be more suitable for short-term palliation. Endoscopic papillotomy has proven to be successful nonoperative therapy for choledocholithiasis and also permits retrograde placement of transpapillary stents. Communication and collaboration among the radiologist, endoscopist, and biliary surgeon are essential if these new methods are to be applied optimally to the various clinical problems encountered with bile duct obstruction.

Bile Duct Diseases↗

Ultrasonic visualization of the pancreatic duct.

The frequency and significance of pancreatic duct visualization by ultrasonography were correlated with endoscopic retrograde cholangiopancreatography or pancreatic computed tomography. The normal pancreatic duct was found to have parallel walls and to be less than 2 mm in internal diameter in the region of the body of the pancreas. The abdominal pancreatic duct had an internal diameter of 2 mm or greater or had walls that were nonparallel or convex outward (focal dilatation or beading). Pancreatic ducts were identified in approximately one-half of all patients evaluated. Failure to visualize an abnormally dilated pancreatic duct was secondary to distortion of pancreatic anatomy from large or multiple pseudocysts, calcific deposits within the pancreas, or technically poor visualization of the pancreas.

Cholangiopancreatography, Endoscopic Retrograde↗

Evaluation of 12 colon-cleansing regimens with single-contrast barium enema.

In a study of patient preparation for barium enemas, 1,435 patients were examined at six different institutions with 12 different preparation protocols. There were 2,870 films evaluated a total of 7,839 times by seven different radiologists who were blind to both the institution and the preparations used. The statistical design, randomization, and analysis of the data obtained was performed by one of the authors, a statistician, and the following conclusions were made: Dulcolax (bisacodyl) plus 2 L tapwater enema is better than all the other protocols in all parts of the colon for both genders and all ages. Dulcolax or castor oil or X-Prep, each with 2 L water enema, are logically similar and better than the other protocols. Water enema only or castor oil only are the least effective protocols.

Barium Sulfate↗

Gallstone dissolution using mono-octanoin infusion through an endoscopically placed nasobiliary catheter.

Endoscopic sphincterotomy is widely being used for the treatment of common bile duct stones. In a small group of patients the gallstones are large in size and, hence, difficult to be extracted after a successful endoscopic sphincterotomy. We used a constant infusion of mono-octanoin through a nasobiliary catheter in nine such patients. This method was successful in partial or complete dissolution of the stones in 74% of the patients. In the remaining 36% of the patients, the stones were noted to be soft allowing easy extraction by crushing.

Caprylates↗