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Biomedical subjects

E T O'Brien

Publications and source records attributed to E T O'Brien.

At least 91 records · Page 5Linked to original sources

Classification and management of carpal dislocations.

A classification and plan of management for carpal dislocations are presented, based upon the following basic premises: perilunate and lunate dislocations are different stages of the same injury and are therefore managed identically; displacement may be either dorsal or volar; anatomic restoration of the 3 key elements (scaphoid, lunate, and capitate) is essential. Following initial closed reduction, rotary subluxation of the scaphoid and intercalary segment instability must be specifically looked for and corrected in the patient with perilunate or lunate dislocation without fracture of the scaphoid. In transcaphoid perilunate dislocation, anatomic reduction of the scaphoid fracture and maintenance of that reduction is necessary to prevent nonunion of the fracture and/or late dorsiflexion instability of the carpus. As with all ligamentous injuries, early diagnosis and treatment are essential. Failure to obtain or maintain anatomic position by closed methods is an indication for open reduction and internal fixation. Combined dorsal and volar approaches are recommended for perilunate and lunate dislocations. In some cases of transscaphoid perilunate dislocation, a limited Russe approach to stabilize the scaphoid fracture may be sufficient. Frequent concomitant injuries include median nerve damage, osteochondral fractures of the carpal bones, and fracture of the radial styloid. Isolated rotary subluxation of the scaphoid without perilunate dislocation is a more subtle injury which may require special radiographic views, and also demands early diagnosis and treatment.

Carpal Bones↗

The clinical pharmacology of vasodilator antihypertensive drugs.

Vasodilator antihypertensive agents are defined and classified according to their mechanism and site of action. The effects of minoxidil, in combination with propranolol and a diuretic, on renal blood flow and renal function were studied following acute and chronic therapy. Although renal blood flow is reduced after two weeks on minoxidil, renal blood flow and renal function are not compromised after one year. The haemodynamic effects and pharmacokinetic profile of acute dosing with tolmesoxide, a new vasodilator antihypertensive agent are described. Results suggest that the long-term efficacy and safety of this drug are worth studying.

Antihypertensive Agents↗

Advantages and disadvantages of beta-adrenergic blocking drugs in hypertension.

This paper reviews the role of beta-adrenergic blocking drugs in the treatment of hypertension. A significant proportion of patients presenting with mild or moderate hypertension will respond to general measures and do not require specific drug therapy. Of the remaining patients, some will respond to treatment with a thiazide diuretic alone, and those with severe grades of hypertension will require the addition of a beta-adrenergic blocking drug, occasionally together with a vasodilator. The advantages of beta-adrenergic lbocking drugs alone or in combination and the problems associated with therapy are discussed.

Adrenergic beta-Antagonists↗

Remodeling of the femoral neck after in situ pinning for slipped capital femoral epiphysis.

During a period of thirty-six years, sixty-two patients with seventy slipped capital femoral epiphyses were treated by pinning in situ. Twelve of these patients, ten years and eight months to sixteen years and one month old, were treated for moderate to severe slipping by pinning in situ. After follow-ups ranging from two to seventeen years, all but two patients had satisfactory remodeling of the femoral head and neck and were asymptomatic. The two with incomplete or no remodeling had no symptoms. It was concluded that the effects of remodeling have been largely ignored and that pinning in situ when possible, followed if necessary by osteoplasty or osteotomy through the lesser trochanter, is a safe and effective treatment.

Adolescent↗

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History, 17th Century↗